Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Pei Pei Hsieh"'
Autor:
Sandra Wimberger, Nina Akrap, Mike Firth, Johan Brengdahl, Susanna Engberg, Marie K. Schwinn, Michael R. Slater, Anders Lundin, Pei-Pei Hsieh, Songyuan Li, Silvia Cerboni, Jonathan Sumner, Burcu Bestas, Bastian Schiffthaler, Björn Magnusson, Silvio Di Castro, Preeti Iyer, Mohammad Bohlooly-Y, Thomas Machleidt, Steve Rees, Ola Engkvist, Tyrell Norris, Elaine B. Cadogan, Josep V. Forment, Saša Šviković, Pinar Akcakaya, Amir Taheri-Ghahfarokhi, Marcello Maresca
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Genome editing, specifically CRISPR/Cas9 technology, has revolutionized biomedical research and offers potential cures for genetic diseases. Despite rapid progress, low efficiency of targeted DNA integration and generation of unintended muta
Externí odkaz:
https://doaj.org/article/4bb0c69502654c769c92ef8642d93a46
Autor:
Martin Peterka, Nina Akrap, Songyuan Li, Sandra Wimberger, Pei-Pei Hsieh, Dmitrii Degtev, Burcu Bestas, Jack Barr, Stijn van de Plassche, Patricia Mendoza-Garcia, Saša Šviković, Grzegorz Sienski, Mike Firth, Marcello Maresca
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Prime editing is a next-generation approach for precision genome engineering. Here the authors design a nuclease-based prime editor that leverages DNA repair pathways for targeted genomic insertions.
Externí odkaz:
https://doaj.org/article/25fe27eaf624442f9610f0f8e6483f5c
Autor:
Sandra Wimberger, Nina Akrap, Mike Firth, Johan Brengdahl, Susanna Engberg, Marie K. Schwinn, Michael R. Slater, Anders Lundin, Pei-Pei Hsieh, Songyuan Li, Silvia Cerboni, Jonathan Sumner, Burcu Bestas, Bastian Schiffthaler, Björn Magnusson, Silvio Di Castro, Preeti Iyer, Bohlooly-Y Mohammad, Thomas Machleidt, Steve Rees, Ola Engkvist, Tyrell Norris, Elaine Cadogan, Josep V. Forment, Saša Šviković, Pinar Akcakaya, Amir Taheri-Ghahfarokhi, Marcello Maresca
Genome editing tools, especially CRISPR/Cas9-based strategies, have transformed biomedical research and opened opportunities for developing curative treatments for genetic diseases. Despite rapid progress, low efficiency of targeted DNA integration a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a08601f80723c09f5557274e0ab558c2
https://doi.org/10.1101/2022.12.15.520396
https://doi.org/10.1101/2022.12.15.520396
Autor:
Sandra Wimberger, Burcu Bestas, Pei-Pei Hsieh, Mike Firth, Marcello Maresca, Grzegorz Sienski, Stijn van de Plassche, Songyuan Li, Saša Šviković, Dmitrii Degtev, Martin Peterka, Patricia Mendoza-Garcia, Nina Akrap, Jack Barr
Publikováno v:
Nature communications. 13(1)
Prime editing recently emerged as a next-generation approach for precise genome editing. Here we exploit DNA double-strand break (DSB) repair to develop two novel strategies that install precise genomic insertions using an SpCas9 nuclease-based prime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8acc9ccbe14cde5ee287111806a787de
https://pubmed.ncbi.nlm.nih.gov/35332138
https://pubmed.ncbi.nlm.nih.gov/35332138
Publikováno v:
Rheumatology (Oxford, England). 51(3)
Objectives RA is the most common form of inflammatory arthritis. IL-19 acts as a pro-inflammatory cytokine involved in the pathogenesis of RA. We investigated whether anti-IL-19 antibody treatment would modulate the severity of the disease in a CIA r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2515cb6ace62178c71e4a6d36d275f43
https://pubmed.ncbi.nlm.nih.gov/21719415
https://pubmed.ncbi.nlm.nih.gov/21719415