Expansion and characterization of human melanoma tumor-infiltrating lymphocytes (TILs).

Autor: Linh T Nguyen, Pei Hua Yen, Jessica Nie, Nicole Liadis, Danny Ghazarian, Ayman Al-Habeeb, Alexandra Easson, Wey Leong, Joan Lipa, David McCready, Michael Reedijk, David Hogg, Anthony M Joshua, Ian Quirt, Hans Messner, Patricia Shaw, Michael Crump, Eran Sharon, Pamela S Ohashi

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e13940 (2010)

BackgroundVarious immunotherapeutic strategies for cancer are aimed at augmenting the T cell response against tumor cells. Adoptive cell therapy (ACT), where T cells are manipulated ex vivo and subsequently re-infused in an autologous manner, has bee

Externí odkaz: https://doaj.org/article/fd7e427dc12b40768de11d9f16cd9cac

Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2

Autor: Anthony M. Joshua, Wey Leong, Habeeb Majeed, Ayman Al-Habeeb, Michael Reedijk, Pamela S. Ohashi, Michael Fyrsta, Diana Gray, Charlotte Lo, Stephanie Effendi, Pei Hua Yen, Samuel Saibil, Jennifer Y. Yam, Danny Ghazarian, Alexandra M. Easson, Aaron R. Hansen, Sarah Boross-Harmer, Michael X. Le, Jessica Nie, Kazuhiro Yasufuku, Ragitha Ellenchery, Leila Khoja, Megan E. Nelles, Linh T. Nguyen, Anna Spreafico, Elizabeth Scheid, Luisa Bonilla, Bianzheng Zhang, David P. Goldstein, Michael Crump, Marcus O. Butler, David Hogg, Thomas K. Waddell, Stephanie DeLuca, Jane Cipollone, Alisha R. Elford, Valentin Sotov, Lisa Wang, Naoto Hirano, Marcelo Cypel, Vinicius Motta, Andrew Pierre, David R. McCready, Norman Franke

Publikováno v: Cancer Immunology, Immunotherapy. 68:773-785

Adoptive cell therapy using autologous tumor-infiltrating lymphocytes (TIL) has shown significant clinical benefit, but is limited by toxicities due to a requirement for post-infusion interleukin-2 (IL-2), for which high dose is standard. To assess a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7347afc3b666284c9bceccd0e72757
https://doi.org/10.1007/s00262-019-02307-x

A distinct innate lymphoid cell population regulates tumor-associated T cells

Autor: Pamela S. Ohashi, Yam Jy, Sowamber R, Linh T. Nguyen, Trevor J. Pugh, Hal K. Berman, Dylan Johnson, Philipp A. Lang, Katz, Bernard Martin, Anca Milea, Pniak M, Blaise A. Clarke, Lewis L. Lanier, Jessica Nie, Sandra López-Vergès, Sarah Q. Crome, Pei Hua Yen, Marcus Q. Bernardini, Patricia Shaw, Yang Sy

Publikováno v: Crome, SQ; Nguyen, LT; Lopez-Verges, S; Yang, SYC; Martin, B; Yam, JY; et al.(2017). A distinct innate lymphoid cell population regulates tumor-associated T cells. NATURE MEDICINE, 23(3), 368-375. doi: 10.1038/nm.4278. UCSF: Retrieved from: http://www.escholarship.org/uc/item/92j0v6vt
Nature medicine, vol 23, iss 3

Antitumor T cells are subject to multiple mechanisms of negative regulation1–3. Recent findings that innate lymphoid cells (ILCs) regulate adaptive T cell responses4–6 led us to examine the regulatory potential of ILCs in the context of cancer. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c528f03209e99df979f4eafcc2656428
http://www.escholarship.org/uc/item/92j0v6vt

Measurement of analytical knowledge-based corporate memory and its application

Autor: Pei-Hua Yen, Chun-Che Huang, Yu-Neng Fan, Ching-Chin Chern

Publikováno v: Decision Support Systems. 54:846-857

In the current knowledge-driven economy, businesses are increasingly required to function as knowledge-based organizations. In these organizations, knowledge usually serves as the means for attainment of competitive advantage. It is clear that organi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6c54a20d6470131074b7c4b92a1c68a
https://doi.org/10.1016/j.dss.2012.09.010

Design and Implementation of a Computer Forensics System

Autor: Pei-Hua Yen, 嚴珮華

98
As the popularity of the internet continues growing, not only change our life, but also change the way of crime. Number of crime by computer as tools, place or target, cases of such offenders increases these days, fact to the crime of compute

Externí odkaz: http://ndltd.ncl.edu.tw/handle/70057386437910338832