Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Pei Fen Kuan"'
Autor:
Xu Ren, Pei Fen Kuan
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237006 (2020)
Biological aging reflects decline in physiological functions and is an effective indicator of morbidity and mortality. Numerous epigenetic age calculators are available, however biological aging calculators based on transcription remain scarce. Here,
Externí odkaz:
https://doaj.org/article/819e7adf37234ba9920f26696a42519c
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-9 (2017)
Abstract Background CRISPR is a versatile gene editing tool which has revolutionized genetic research in the past few years. Optimizing sgRNA design to improve the efficiency of target/DNA cleavage is critical to ensure the success of CRISPR screens.
Externí odkaz:
https://doaj.org/article/60c33ae812664b9fae688b0865d9734f
Autor:
Matthew J Cooper, Nathan J Cox, Eric I Zimmerman, Brian J Dewar, James S Duncan, Martin C Whittle, Thien A Nguyen, Lauren S Jones, Sreerupa Ghose Roy, David M Smalley, Pei Fen Kuan, Kristy L Richards, Richard I Christopherson, Jian Jin, Stephen V Frye, Gary L Johnson, Albert S Baldwin, Lee M Graves
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66755 (2013)
Protein kinases play key roles in oncogenic signaling and are a major focus in the development of targeted cancer therapies. Imatinib, a BCR-Abl tyrosine kinase inhibitor, is a successful front-line treatment for chronic myelogenous leukemia (CML). H
Externí odkaz:
https://doaj.org/article/5e341c4d37844eceabaaf81238a3ae18
Autor:
Dongjun Chung, Pei Fen Kuan, Bo Li, Rajendran Sanalkumar, Kun Liang, Emery H Bresnick, Colin Dewey, Sündüz Keleş
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 7, p e1002111 (2011)
Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) is rapidly replacing chromatin immunoprecipitation combined with genome-wide tiling array analysis (ChIP-chip) as the preferred approach for mapping transcription-factor
Externí odkaz:
https://doaj.org/article/557b1a0a846f4972a5cd394478af23a7
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Proteomics provides an opportunity to develop biomarkers for the early detection and monitoring of post-traumatic stress disorder (PTSD). However, research to date has been limited by small sample sizes and a lack of replication. This study
Externí odkaz:
https://doaj.org/article/d98db2477803416eb7be0979343ed194
Publikováno v:
Epigenetics, Vol 17, Iss 10, Pp 1281-1298 (2022)
Animal domestication is a process of environmental modulation and artificial selection leading to permanent phenotypic modifications. Recent studies showed that phenotypic changes occur very early in domestication, i.e., within the first generation i
Externí odkaz:
https://doaj.org/article/e0d75a6559f94930bf85a082ed94e34d
Autor:
Farrukh M. Koraishy, Frank D. Mann, Monika A. Waszczuk, Pei-Fen Kuan, Katherine Jonas, Xiaohua Yang, Anna Docherty, Andrey Shabalin, Sean Clouston, Roman Kotov, Benjamin Luft
Publikováno v:
BMC Nephrology, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background The factors associated with estimated glomerular filtrate rate (eGFR) decline in low risk adults remain relatively unknown. We hypothesized that a polygenic risk score (PRS) will be associated with eGFR decline. Methods We analyze
Externí odkaz:
https://doaj.org/article/74d6162379124cb5adce09381062222c
Autor:
Ginny Natale, Minos Kritikos, Pei-Fen Kuan, Melissa A. Carr, Xiaohua Yang, Yuan Yang, Roman Kotov, Evelyn J. Bromet, Sean A.P. Clouston, Benjamin J. Luft
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 30, Iss , Pp 100631- (2023)
Background: Chronically re-experiencing the memory of a traumatic event might cause a glial response. This study examined whether glial activation would be associated with PTSD in a study of responders present after the 9/11 World Trade Center attack
Externí odkaz:
https://doaj.org/article/e9bfe056278d4f3aac94223c12c5f39c
Autor:
Irene Orlow, Keimya D Sadeghi, Sharon N Edmiston, Jessica M Kenney, Cecilia Lezcano, James S Wilmott, Anne E Cust, Richard A Scolyer, Graham J Mann, Tim K Lee, Hazel Burke, Valerie Jakrot, Ping Shang, Peter M Ferguson, Tawny W Boyce, Jennifer S Ko, Peter Ngo, Pauline Funchain, Judy R Rees, Kelli O'Connell, Honglin Hao, Eloise Parrish, Kathleen Conway, Paul B Googe, David W Ollila, Stergios J Moschos, Eva Hernando, Douglas Hanniford, Diana Argibay, Christopher I Amos, Jeffrey E Lee, Iman Osman, Li Luo, Pei-Fen Kuan, Arshi Aurora, Bonnie E Gould Rothberg, Marcus W Bosenberg, Meg R Gerstenblith, Cheryl Thompson, Paul N Bogner, Ivan P Gorlov, Sheri L Holmen, Elise K Brunsgaard, Yvonne M Saenger, Ronglai Shen, Venkatraman Seshan, Eduardo Nagore, Marc S Ernstoff, Klaus J Busam, Colin B Begg, Nancy E Thomas, Marianne Berwick, InterMEL Consortium
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0269324 (2023)
IntroductionWe are conducting a multicenter study to identify classifiers predictive of disease-specific survival in patients with primary melanomas. Here we delineate the unique aspects, challenges, and best practices for optimizing a study of gener
Externí odkaz:
https://doaj.org/article/2122630446b94345873b74cdda1850a8
Autor:
Minos Kritikos, Erica D. Diminich, Jaymie Meliker, Michelle Mielke, David A. Bennett, Caleb E. Finch, Sam E. Gandy, Melissa A. Carr, Xiaohua Yang, Roman Kotov, Pei‐Fen Kuan, Evelyn J. Bromet, Sean A. P. Clouston, Benjamin J. Luft
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract Introduction World Trade Center (WTC) responders are experiencing a high risk of mild cognitive impairment (MCI) and dementia, though the etiology remains inadequately characterized. This study investigated whether WTC exposures and chronic
Externí odkaz:
https://doaj.org/article/c4843fc99af04f9998d0e856cd5b5a46