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Data from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Metastatic breast cancer is still incurable so far; new specifically targeted and more effective therapies for triple-negative breast cancer (TNBC) are required in the clinic. In this study, our clinical data have established that basal and claudin-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19a0c0e006c3abbabd69d14315bda93e
https://doi.org/10.1158/1535-7163.c.6539263.v1

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Supplementary Figure 1 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 1: High ANXA1 and PPARγ expression levels positively correlates with the invasive, high-grade phenotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796a52bb0d216b583547635ad48b7918
https://doi.org/10.1158/1535-7163.22509319

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Supplementary Figure 2 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 2: ANXA1 expressing TNBC cell lines display greater sensitivity to PPARγ ligands compared to ANXA1 depleted cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48392110051076c68f80b12a3c9855ed
https://doi.org/10.1158/1535-7163.22509316

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Supplemental Data from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary methods and supplementary figure legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a6963a538aeeeffe32e7e217be5f31
https://doi.org/10.1158/1535-7163.22509322.v1

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Supplementary Figure 3 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 3: PPARγ induced expression of ANXA1 and cell death is abrogated in TNBC cells with pre-incubation of a PPARγ-specific antagonist or use of a dominant negative derivative of PPARγ.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0f8a276b53f71a91851a1a8a4f6ab9
https://doi.org/10.1158/1535-7163.22509313.v1

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Supplementary Figure 4 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 4: PPARγ ligand-induced changes in expression of RIP1 and NEMO and therefore NFκB activity are receptor dependent.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970d9325507dd54cc45444196a0bdeaf
https://doi.org/10.1158/1535-7163.22509310

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PPARγ Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Publikováno v: Molecular cancer therapeutics. 16(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6b4568d7d71813c9560d4fb20f7cf8
https://pubmed.ncbi.nlm.nih.gov/29021293

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