Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Pei Chi Yang"'
Autor:
Gonzalo Hernandez-Hernandez, Samantha C O'Dwyer, Pei-Chi Yang, Collin Matsumoto, Mindy Tieu, Zhihui Fong, Timothy J Lewis, L Fernando Santana, Colleen E Clancy
Publikováno v:
eLife, Vol 12 (2024)
The function of the smooth muscle cells lining the walls of mammalian systemic arteries and arterioles is to regulate the diameter of the vessels to control blood flow and blood pressure. Here, we describe an in silico model, which we call the ‘Her
Externí odkaz:
https://doaj.org/article/e1c78cfe649246afb454472a4d6e05a3
Autor:
Parya Aghasafari, Pei-Chi Yang, Divya C Kernik, Kazuho Sakamoto, Yasunari Kanda, Junko Kurokawa, Igor Vorobyov, Colleen E Clancy
Publikováno v:
eLife, Vol 10 (2021)
The development of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) has been a critical in vitro advance in the study of patient-specific physiology, pathophysiology, and pharmacology. We designed a new deep learning multitask network
Externí odkaz:
https://doaj.org/article/1cce6aa896514b5586df70ba8213b166
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1008109 (2020)
In the last decade, there has been tremendous progress in identifying genetic anomalies linked to clinical disease. New experimental platforms have connected genetic variants to mechanisms underlying disruption of cellular and organ behavior and the
Externí odkaz:
https://doaj.org/article/cd9eeae8737b439684cd9e37115ffe67
Autor:
Pei-Chi Yang, M. Saleet Jafri
Publikováno v:
Heliyon, Vol 6, Iss 3, Pp e03526- (2020)
T cell receptor stimulation initiates a cascade of reactions that cause an increase in intracellular calcium (Ca2+) concentration mediated through inositol 1,4,5-trisphosphate (IP3). To understand the basic mechanisms by which the immune response in
Externí odkaz:
https://doaj.org/article/55549d88cb7a48499a1923895f4907f3
Autor:
Tian-Hoe Tan, Ting-Ya Yang, Yao-Mei Chen, Shiu-Yuan Chung, Hsiao-Hua Liu, Pei-Chi Yang, Pei-Hsin Kao, An-Chi Peng, Yi-Min Shu, Yu-Sheng Chu, Kang-Ting Tsai, Chien-Chin Hsu, Chung-Han Ho, Hung-Jung Lin, Chien-Cheng Huang
Publikováno v:
Aging Clinical and Experimental Research. 34:3137-3144
A computerized tool and interdisciplinary care were implemented to develop a novel model for older patients with delirium in the emergency department (ED).We developed a computerized tool using a delirium triage screen and brief confusion assessment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1590ba1a449655a495b11b256db82349
https://doi.org/10.1007/s40520-022-02240-7
https://doi.org/10.1007/s40520-022-02240-7
Autor:
Hernandez-Hernandez, Gonzalo, O'Dwyer, Samantha C., Pei-Chi Yang, Matsumoto, Collin, Tieu, Mindy, Zhihui Fong, Lewis, Timothy J., Santana, L. Fernando, Clancy, Colleen E.
Publikováno v:
eLife; 2/9/2024, p1-30, 30p
Autor:
Pei-Chi Yang, Shweta Purawat, Pek U Ieong, Mao-Tsuen Jeng, Kevin R DeMarco, Igor Vorobyov, Andrew D McCulloch, Ilkay Altintas, Rommie E Amaro, Colleen E Clancy
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 3, p e1006856 (2019)
Multi-scale computational modeling is a major branch of computational biology as evidenced by the US federal interagency Multi-Scale Modeling Consortium and major international projects. It invariably involves specific and detailed sequences of data
Externí odkaz:
https://doaj.org/article/a9798631d43e4238936e418a85225114
Autor:
Laura L. Perissinotti, Pablo M. De Biase, Jiqing Guo, Pei-Chi Yang, Miranda C. Lee, Colleen E. Clancy, Henry J. Duff, Sergei Y. Noskov
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
IKr is the rapidly activating component of the delayed rectifier potassium current, the ion current largely responsible for the repolarization of the cardiac action potential. Inherited forms of long QT syndrome (LQTS) (Lees-Miller et al., 1997) in h
Externí odkaz:
https://doaj.org/article/55a6b48ac7ca4144877062bf442031c9
Autor:
Shailesh R. Agarwal, Jackson Gratwohl, Mia Cozad, Pei-Chi Yang, Colleen E. Clancy, Robert D. Harvey
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Aim: Confining cAMP production to discrete subcellular locations makes it possible for this ubiquitous second messenger to elicit unique functional responses. Yet, factors that determine how and where the production of this diffusible signaling molec
Externí odkaz:
https://doaj.org/article/3a15214abe604b31a84320228dbc70d7
Autor:
Slava Bekker, Mao Tsuen Jeng, Heike Wulff, Colleen E. Clancy, Van A. Ngo, Pei Chi Yang, Kazuharu Furutani, James C. Fettinger, Vladimir Yarov-Yarovoy, Vikrant Singh, Igor Vorobyov, Sergei Y. Noskov, Jon T. Sack, Kevin R. DeMarco, John R. D. Dawson
Publikováno v:
Journal of Molecular and Cellular Cardiology. 158:163-177
Drug isomers may differ in their proarrhythmia risk. An interesting example is the drug sotalol, an antiarrhythmic drug comprising d- and l- enantiomers that both block the hERG cardiac potassium channel and confer differing degrees of proarrhythmic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca30f9d545d92906b5d654c03d7da00
https://doi.org/10.1016/j.yjmcc.2021.05.015
https://doi.org/10.1016/j.yjmcc.2021.05.015