Zobrazeno 1 - 10
of 714
pro vyhledávání: '"Pei‐Yong Shi"'
Autor:
Lijing Zhang, Xuping Xie, Hannan Luo, Runtong Qian, Yang Yang, Hongtao Yu, Jing Huang, Pei-Yong Shi, Qi Hu
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Drug resistance poses a significant challenge in the development of effective therapies against SARS-CoV-2. Here, we identified two double mutations, M49K/M165V and M49K/S301P, in the 3C-like protease (3CLpro) that confer resistance to a nov
Externí odkaz:
https://doaj.org/article/b44f440683454d9aba992e81fbac8de0
Autor:
Hui Wang, Yashoda M. Hosakote, Paul J. Boor, Jun Yang, Yuanyi Zhang, Xiaoying Yu, Casey Gonzales, Corri B. Levine, Susan McLellan, Nicole Cloutier, Xuping Xie, Pei-Yong Shi, Ping Ren, Haitao Hu, Keer Sun, Lynn Soong, Jiaren Sun, Yuejin Liang
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110117- (2024)
Summary: Dysregulated host immune responses contribute to disease severity and worsened prognosis in COVID-19 infection and the underlying mechanisms are not fully understood. In this study, we observed that IL-33, a damage-associated molecular patte
Externí odkaz:
https://doaj.org/article/05478d599ee54e169c154b5090b33c58
Autor:
Jiakai Hou, Yanjun Wei, Jing Zou, Roshni Jaffery, Long Sun, Shaoheng Liang, Ningbo Zheng, Ashley M. Guerrero, Nicholas A. Egan, Ritu Bohat, Si Chen, Caishang Zheng, Xiaobo Mao, S. Stephen Yi, Ken Chen, Daniel J. McGrail, Nidhi Sahni, Pei-Yong Shi, Yiwen Chen, Xuping Xie, Weiyi Peng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we perform a genome-wide CR
Externí odkaz:
https://doaj.org/article/40cc73e86a42414c8dbcd229f50f5fe6
Autor:
Jule Goike, Ching-Lin Hsieh, Andrew P. Horton, Elizabeth C. Gardner, Ling Zhou, Foteini Bartzoka, Nianshuang Wang, Kamyab Javanmardi, Andrew Herbert, Shawn Abbassi, Xuping Xie, Hongjie Xia, Pei-Yong Shi, Rebecca Renberg, Thomas H. Segall-Shapiro, Cynthia I. Terrace, Wesley Wu, Raghav Shroff, Michelle Byrom, Andrew D. Ellington, Edward M. Marcotte, James M. Musser, Suresh V. Kuchipudi, Vivek Kapur, George Georgiou, Scott C. Weaver, John M. Dye, Daniel R. Boutz, Jason S. McLellan, Jimmy D. Gollihar
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract The ongoing evolution of SARS-CoV-2 into more easily transmissible and infectious variants has provided unprecedented insight into mutations enabling immune escape. Understanding how these mutations affect the dynamics of antibody-antigen in
Externí odkaz:
https://doaj.org/article/e176e0ac10fe413398cba9041336c98a
Autor:
Kuo-Chieh Liao, Xuping Xie, Anna Karin Beatrice Sundstrom, Xin Ni Lim, Kiat Kee Tan, Yu Zhang, Jing Zou, Amanda Makha Bifani, Hui Xian Poh, Jia Jia Chen, Wy Ching Ng, Su Ying Lim, Eng Eong Ooi, October M. Sessions, Yvonne Tay, Pei-Yong Shi, Roland G. Huber, Yue Wan
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-17 (2023)
Abstract Background Identifying host factors is key to understanding RNA virus pathogenicity. Besides proteins, RNAs can interact with virus genomes to impact replication. Results Here, we use proximity ligation sequencing to identify virus-host RNA
Externí odkaz:
https://doaj.org/article/47da49f037b74b8e94d5fc3d0069ec9f
Autor:
Ankita Singh, Awadalkareem Adam, Aditi, Bi-Hung Peng, Xiaoying Yu, Jing Zou, Vikram V. Kulkarni, Peter Kan, Wei Jiang, Pei-Yong Shi, Parimal Samir, Irma Cisneros, Tian Wang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Viral variant is one known risk factor associated with post-acute sequelae of COVID-19 (PASC), yet the pathogenesis is largely unknown. Here, we studied SARS-CoV-2 Delta variant-induced PASC in K18-hACE2 mice. The virus replicated productively, induc
Externí odkaz:
https://doaj.org/article/1086a573751c4191956361de2d95bb29
Autor:
Awadalkareem Adam, Birte Kalveram, John Yun-Chung Chen, Jason Yeung, Leslie Rodriguez, Ankita Singh, Pei-Yong Shi, Xuping Xie, Tian Wang
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-6 (2023)
Abstract An attenuated SARS-CoV-2 virus with modified viral transcriptional regulatory sequences and deletion of open-reading frames 3, 6, 7 and 8 (∆3678) was previously reported to protect hamsters from SARS-CoV-2 infection and transmission. Here
Externí odkaz:
https://doaj.org/article/24e5820da76b4b738bd7f99fa9c70bf4
Autor:
Yanping Hu, Jing Zou, Chaitanya Kurhade, Xiangxue Deng, Hope C. Chang, Debora K. Kim, Pei-Yong Shi, Ping Ren, Xuping Xie
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
The highly mutated BA.2.86, with over 30 spike protein mutations in comparison to Omicron BA.2 and XBB.1.5 variants, has raised concerns about its potential to evade COVID-19 vaccination or prior SARS-CoV-2 infection-elicited immunity. In this study,
Externí odkaz:
https://doaj.org/article/1701d36387e84cb1888a7ae518cbfd78
Autor:
Cody J. Bills, Hongjie Xia, John Yun-Chung Chen, Jason Yeung, Birte K. Kalveram, David Walker, Xuping Xie, Pei-Yong Shi
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 1 (2023)
ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve after its emergence. Given its importance in viral infection and vaccine development, mutations in the viral Spike gene have been studied extensively; however, t
Externí odkaz:
https://doaj.org/article/56f69a925c4e4733a1fc4da4467f646a
Autor:
Hongjie Xia, Jason Yeung, Birte Kalveram, Cody J. Bills, John Yun-Chung Chen, Chaitanya Kurhade, Jing Zou, Steven G. Widen, Brian R. Mann, Rebecca Kondor, C. Todd Davis, Bin Zhou, David E. Wentworth, Xuping Xie, Pei-Yong Shi
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 1 (2023)
ABSTRACTThe rapid evolution of SARS-CoV-2 Omicron sublineages mandates a better understanding of viral replication and cross-neutralization among these sublineages. Here we used K18-hACE2 mice and primary human airway cultures to examine the viral fi
Externí odkaz:
https://doaj.org/article/47204c3dfe2f402294bba8cbafe7c13a