Výsledky vyhledávání - "Pei‐Ching Hsiao"

Akademický článek

Pterostilbene simultaneously induced G0/G1-phase arrest and MAPK-mediated mitochondrial-derived apoptosis in human acute myeloid leukemia cell lines.

Autor: Pei-Ching Hsiao, Ying-Erh Chou, Peng Tan, Wei-Jiunn Lee, Shun-Fa Yang, Jyh-Ming Chow, Hui-Yu Chen, Chien-Huang Lin, Liang-Ming Lee, Ming-Hsien Chien

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105342 (2014)

Pterostilbene (PTER) is a dimethylated analog of the phenolic phytoalexin, resveratrol, with higher anticancer activity in various tumors. Herein, the molecular mechanisms by which PTER exerts its anticancer effects against acute myeloid leukemia (AM

Externí odkaz: https://doaj.org/article/7e661e2bb30745d48113cb10667d87a0

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Akademický článek

Glabridin mediate caspases activation and induces apoptosis through JNK1/2 and p38 MAPK pathway in human promyelocytic leukemia cells.

Autor: Hsin-Lien Huang, Ming-Ju Hsieh, Ming-Hsien Chien, Hui-Yu Chen, Shun-Fa Yang, Pei-Ching Hsiao

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e98943 (2014)

BACKGROUND: Glabridin, a prenylated isoflavonoid of G. glabra L. roots, has been associated with a wide range of biological properties such as regulation of energy metabolism, estrogenic, neuroprotective, anti-osteoporotic, and skin-whitening in prev

Externí odkaz: https://doaj.org/article/c2023514136f45f7a11b93a528628097

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Akademický článek

Licochalcone A suppresses migration and invasion of human hepatocellular carcinoma cells through downregulation of MKK4/JNK via NF-κB mediated urokinase plasminogen activator expression.

Autor: Jen-Pi Tsai, Pei-Ching Hsiao, Shun-Fa Yang, Shu-Ching Hsieh, Da-Tian Bau, Chu-Liang Ling, Chun-Li Pai, Yi-Hsien Hsieh

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e86537 (2014)

Hepatocellular cell carcinoma (HCC) is one of the most commonly diagnosed cancers worldwide and in Taiwan. Chemoprevention of cancer with dietary bioactive compounds could potentially reverse, suppress, or prevent cancer progression. Licochalcone A (

Externí odkaz: https://doaj.org/article/daa9158162aa419d9bd28a7deec9978b

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Akademický článek

Effects of EZH2 polymorphisms on susceptibility to and pathological development of hepatocellular carcinoma.

Autor: Yung-Luen Yu, Kuo-Jung Su, Yi-Hsien Hsieh, Hsiang-Lin Lee, Tzy-Yen Chen, Pei-Ching Hsiao, Shun-Fa Yang

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74870 (2013)

The enhancer of zeste 2 (EZH2) gene encodes the histone methyltransferase that is the catalytic component of the polycomb repressive complex-2, which initiates epigenetic silencing of genes. The expression level of EZH2 in hepatocellular carcinoma (H

Externí odkaz: https://doaj.org/article/25b2647659d24618918569b87293b64a

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Comparison of molecular responses and outcomes between BCR::ABL1 e14a2 and e13a2 transcripts in chronic myeloid leukemia

Autor: Yi‐Jiun Su, Ming‐Chung Kuo, Tsai‐Yun Chen, Ming‐Chung Wang, Youngsen Yang, Ming‐Chun Ma, Tung‐Liang Lin, Tung‐Huei Lin, Hung Chang, Chieh‐Lin Jerry Teng, Pei‐Ching Hsiao, Chih‐Cheng Chen, Po‐Nan Wang, Lee‐Yung Shih

Publikováno v: Cancer Science. 113:3518-3527

Several studies have compared the molecular responses between e14a2 and e13a2 BCR::ABL1 transcripts in chronic myeloid leukemia (CML) patients treated with front-line imatinib, but there were very limited studies on nilotinib or dasatinib-treated pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e87e2150d5c2e47c09e48b4d21b131
https://doi.org/10.1111/cas.15501

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NOVEL-1st: an observational study to assess the safety and efficacy of nilotinib in newly diagnosed patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase in Taiwan

Publikováno v: International Journal of Hematology. 115:704-712

Nilotinib has been approved for the treatment of Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase (Ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032592d1c1e4fbff114d86c29f453108
https://doi.org/10.1007/s12185-022-03311-1

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The Curcumin Analogue, EF-24, Triggers p38 MAPK-Mediated Apoptotic Cell Death via Inducing PP2A-Modulated ERK Deactivation in Human Acute Myeloid Leukemia Cells

Autor: Chia Chi Ku, Meng Ying Tsai, Shun-Fa Yang, Ming Hsien Chien, Jer Hwa Chang, Wei Jiunn Lee, Pei Ching Hsiao

Publikováno v: Cancers, Vol 12, Iss 2163, p 2163 (2020)
Cancers
Volume 12
Issue 8

Curcumin (CUR) has a range of therapeutic benefits against cancers, but its poor solubility and low bioavailability limit its clinical use. Demethoxycurcumin (DMC) and diphenyl difluoroketone (EF-24) are natural and synthetic curcumin analogues, resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2679069c72c4cd78f7028ece38630b7b
https://www.mdpi.com/2072-6694/12/8/2163

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NOVEL-1st: A Non-Interventional, Multi-Center Observational Study to Assess the Safety and Efficacy of Nilotinib in Newly Diagnosed Patients with Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP) in Taiwan

Autor: Fan-Chen Ku, Chieh-Wen Chen, Tsung-Chih Chen, Hwang Wen-Li, Pei-Ching Hsiao, Yeu-Chin Chen, Jih-Luh Tang, Ta-Chih Liu, Jyh-Pyng Gau, Ching-Yuan Kuo, Ming-Chih Chang, Li Yuan Bai, Shyuann-Yuh Lin, Po-Nan Wang, Yee-Ming Lee

Publikováno v: Blood. 136:2-3

Background Nilotinib, a second-generation tyrosine kinase inhibitor (TKI), has been approved for the treatment of patients with newly diagnosed Philadelphia chromosome positive chronic myeloid leukemia in chronic phase (Ph+ CML-CP) globally, includin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08d6505cd5f82901da21dcde28345db8
https://doi.org/10.1182/blood-2020-137327

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Cantharidic acid induces apoptosis of human leukemic HL-60 cells via c-Jun N-terminal kinase-regulated caspase-8/-9/-3 activation pathway

Autor: Pei Ching Hsiao, Shih Chung Wang, Ming Hsien Chien, Jyh Ming Chow, Shun-Fa Yang, Hui Yu Chen, Chiao Wen Lin

Publikováno v: Environmental toxicology. 33(4)

Cantharidin, a natural toxin from blister beetles, has shown potent anticancer activities on many solid tumor cells. Recently, cantharidin and its analogue, norcantharidin, were also shown to suppress nonsolid tumors such as chronic myeloid leukemia,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594732a149e442ab2c59d1aa6639949e
https://pubmed.ncbi.nlm.nih.gov/29345422

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Tricetin Induces Apoptosis of Human Leukemic HL-60 Cells through a Reactive Oxygen Species-Mediated c-Jun N-Terminal Kinase Activation Pathway

Autor: Pei Ching Hsiao, Hui Yu Chen, Ming Hsien Chien, Wei Jiunn Lee, Peng Tan, Yung Wei Lin, Jyh Ming Chow, Shun-Fa Yang, Yu Ching Wen

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 8, p 1667 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 8; Pages: 1667

Tricetin is a dietary flavonoid with cytostatic properties and antimetastatic activities in various solid tumors. The anticancer effect of tricetin in nonsolid tumors remains unclear. Herein, the molecular mechanisms by which tricetin exerts its anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161ec515c3bda750b1c3b73071b56165
https://pubmed.ncbi.nlm.nih.gov/28758971

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