ETS1, a target gene of the EWSR1::FLI1 fusion oncoprotein, regulates the expression of the focal adhesion protein TENSIN3.

Autor: Ebegboni VJ; Functional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Jones TL; Functional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Brownmiller T; Functional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Zhao PX; Omics Bioinformatics Facility, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Pehrsson EC; Omics Bioinformatics Facility, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Rajan SS; Functional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Caplen NJ; Functional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 23. Date of Electronic Publication: 2023 Dec 23.

Tumor biology and immune infiltration define primary liver cancer subsets linked to overall survival after immunotherapy.

Autor: Budhu A; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Pehrsson EC; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; CCR Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., He A; Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA., Goyal L; Department of Medical Oncology, Mass General Cancer Center, Harvard Medical School, Boston, MA 02114, USA., Kelley RK; Department of Medicine (Hematology/Oncology), UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94143, USA., Dang H; Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA; Sidney Kimmel Cancer Center, Philadelphia, PA 19107, USA., Xie C; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Monge C; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Tandon M; CCR Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Ma L; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Revsine M; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Kuhlman L; Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA., Zhang K; Department of Medicine (Hematology/Oncology), UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94143, USA., Baiev I; Department of Medical Oncology, Mass General Cancer Center, Harvard Medical School, Boston, MA 02114, USA., Lamm R; Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA; Sidney Kimmel Cancer Center, Philadelphia, PA 19107, USA., Patel K; Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA; Sidney Kimmel Cancer Center, Philadelphia, PA 19107, USA., Kleiner DE; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 21701, USA., Hewitt SM; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 21701, USA., Tran B; Sequencing Facility, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA., Shetty J; Sequencing Facility, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA., Wu X; Genomics Technology Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA., Zhao Y; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Shen TW; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Choudhari S; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Kriga Y; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Ylaya K; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 21701, USA., Warner AC; Molecular Histopathology Laboratory, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA., Edmondson EF; Molecular Histopathology Laboratory, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA., Forgues M; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Greten TF; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: tim.greten@nih.gov., Wang XW; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: xw3u@nih.gov.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2023 Jun 20; Vol. 4 (6), pp. 101052. Date of Electronic Publication: 2023 May 23.

Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease.

Autor: Zhang B; Department of Genetics Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA; Department of Developmental Biology, Center of Regenerative Medicine, Washington University School of Medicine, St Louis, MO 63108, USA., Kim MY; Ely and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94115, USA; Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94115, USA; Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA., Elliot G; Department of Genetics Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA., Zhou Y; Ely and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94115, USA; Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94115, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94115, USA; Division of Maternal-Fetal Medicine, University of California, San Francisco, San Francisco, CA 94115, USA., Zhao G; Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94115, USA., Li D; Department of Genetics Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA., Lowdon RF; Department of Genetics Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA., Gormley M; Ely and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94115, USA; Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94115, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94115, USA; Division of Maternal-Fetal Medicine, University of California, San Francisco, San Francisco, CA 94115, USA., Kapidzic M; Ely and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94115, USA; Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94115, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94115, USA; Division of Maternal-Fetal Medicine, University of California, San Francisco, San Francisco, CA 94115, USA., Robinson JF; Ely and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94115, USA; Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94115, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94115, USA; Division of Maternal-Fetal Medicine, University of California, San Francisco, San Francisco, CA 94115, USA., McMaster MT; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94122, USA., Hong C; Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA., Mazor T; Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA., Hamilton E; Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA., Sears RL; Department of Genetics Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA., Pehrsson EC; Department of Genetics Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA., Marra MA; Centre for High-Throughput Biology, Department of Microbiology & Immunology, University of British Columbia, 2125 East Mall, Vancouver, BC V6T 1Z4, Canada; Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, 675 West 10th Aven, Vancouver, BC V5Z 1L3, Canada., Jones SJM; Centre for High-Throughput Biology, Department of Microbiology & Immunology, University of British Columbia, 2125 East Mall, Vancouver, BC V6T 1Z4, Canada; Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, 675 West 10th Aven, Vancouver, BC V5Z 1L3, Canada., Bilenky M; Centre for High-Throughput Biology, Department of Microbiology & Immunology, University of British Columbia, 2125 East Mall, Vancouver, BC V6T 1Z4, Canada; Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, 675 West 10th Aven, Vancouver, BC V5Z 1L3, Canada., Hirst M; Centre for High-Throughput Biology, Department of Microbiology & Immunology, University of British Columbia, 2125 East Mall, Vancouver, BC V6T 1Z4, Canada; Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, 675 West 10th Aven, Vancouver, BC V5Z 1L3, Canada., Wang T; Department of Genetics Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA. Electronic address: twang@wustl.edu., Costello JF; Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA. Electronic address: joseph.costello@ucsf.edu., Fisher SJ; Ely and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94115, USA; Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94115, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94115, USA; Division of Maternal-Fetal Medicine, University of California, San Francisco, San Francisco, CA 94115, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94122, USA. Electronic address: susan.fisher@ucsf.edu.

Publikováno v: Developmental cell [Dev Cell] 2021 May 03; Vol. 56 (9), pp. 1238-1252.e5. Date of Electronic Publication: 2021 Apr 22.

A genomic and epigenomic atlas of prostate cancer in Asian populations.

Autor: Li J; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.; Center for Translational Medicine, Second Military Medical University, Shanghai, China.; Shanghai Key Laboratory of Cell Engineering, Shanghai, China., Xu C; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.; Shanghai Key Laboratory of Cell Engineering, Shanghai, China., Lee HJ; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Ren S; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.; Shanghai Key Laboratory of Cell Engineering, Shanghai, China., Zi X; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Zhang Z; Novogene Co, Ltd, Beijing, China., Wang H; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Yu Y; Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China., Yang C; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Gao X; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Hou J; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Wang L; Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai, China., Yang B; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Yang Q; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Ye H; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Zhou T; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Lu X; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Wang Y; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Qu M; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Yang Q; Department of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, China., Zhang W; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Shah NM; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Pehrsson EC; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Wang S; Department of Urology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China., Wang Z; State Key Laboratory of Reproductive Medicine and Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Jiang J; Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China., Zhu Y; Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China., Chen R; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Chen H; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Zhu F; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Lian B; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Li X; Novogene Co, Ltd, Beijing, China., Zhang Y; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Wang C; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Wang Y; Shanghai Key Laboratory of Cell Engineering, Shanghai, China.; Department of Histology and Embryology, Second Military Medical University, Shanghai, China., Xiao G; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Jiang J; Shanghai Key Laboratory of Cell Engineering, Shanghai, China.; Department of Histology and Embryology, Second Military Medical University, Shanghai, China., Yang Y; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China., Liang C; Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, China., Hou J; Department of Urology, First Affiliated Hospital of Soochow University, Suzhou, China., Han C; Department of Urology, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, China., Chen M; Department of Urology, Zhongda Hospital, Southeast University, Nanjing, China., Jiang N; Department of Urology, Gongli Hospital, Second Military Medical University, Shanghai, China., Zhang D; Department of Urology, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, China., Wu S; Department of Urology Institute of Shenzhen University, Shenzhen Luohu People's Hospital, Shenzhen, China., Yang J; Department of Urology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Wang T; Department of Urology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Chen Y; Department of Urology, Shaoxing Central Hospital, Shaoxing, China., Cai J; Department of Urology, Shishi Hospital, Shishi, China., Yang W; Department of Urology, The Affiliated Hospital of Hebei University, Baoding, China., Xu J; Department of Urology, Huadong Hospital, Fudan University, Shanghai, China., Wang S; Department of Urology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China., Gao X; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China. gaoxu.changhai@foxmail.com.; Shanghai Key Laboratory of Cell Engineering, Shanghai, China. gaoxu.changhai@foxmail.com., Wang T; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA. twang@wustl.edu.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA. twang@wustl.edu., Sun Y; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China. sunyhsmmu@126.com.; Shanghai Key Laboratory of Cell Engineering, Shanghai, China. sunyhsmmu@126.com.

Publikováno v: Nature [Nature] 2020 Apr; Vol. 580 (7801), pp. 93-99. Date of Electronic Publication: 2020 Mar 25.

Author Correction: Transposable elements drive widespread expression of oncogenes in human cancers.

Autor: Jang HS; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Shah NM; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Du AY; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Dailey ZZ; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Pehrsson EC; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Godoy PM; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Zhang D; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Li D; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Xing X; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Kim S; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; Hope Center for Neurological Disease, Washington University School of Medicine, St Louis, MO, USA., O'Donnell D; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St Louis, MO, USA., Gordon JI; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St Louis, MO, USA., Wang T; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA. twang@wustl.edu.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA. twang@wustl.edu.

Publikováno v: Nature genetics [Nat Genet] 2019 May; Vol. 51 (5), pp. 920.