Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Peh Yean, Cheah"'
Publikováno v:
Molecular Oncology, Vol 16, Iss 5, Pp 1171-1183 (2022)
KRAS is a gatekeeper gene in human colorectal tumorigenesis. KRAS is ‘undruggable’; hence, efforts have been diverted to inhibit downstream RAF/MEK/ERK and PI3K/Akt signaling. Nevertheless, none of these inhibitors has progressed to clinical use
Externí odkaz:
https://doaj.org/article/9a6cf8a0a2734ec799f79027954a5b05
Autor:
Kuen Kuen Lam, Yee Syuen Low, Michelle Lo, Michelle Wong, Choong Leong Tang, Emile Tan, Aik Yong Chok, Isaac Seow-En, Siew Heng Wong, Peh Yean Cheah
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Colorectal cancer (CRC) is the third highest incidence cancer and a leading cause of cancer mortality worldwide. To date, chemotherapeutic treatment of advanced CRC that has metastasized has a dismayed success rate of less than 30%. Further, most (80
Externí odkaz:
https://doaj.org/article/81b1cebe13f34c0d82560ad6fed3b289
Autor:
Lai Fun Thean, Christopher Blöcker, Hui Hua Li, Michelle Lo, Michelle Wong, Choong Leong Tang, Emile K. W. Tan, Steven G. Rozen, Peh Yean Cheah
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Up-regulation of long non-coding RNAs (lncRNAs), colon-cancer associated transcript (CCAT) 1 and 2, was associated with worse prognosis in colorectal cancer (CRC). Nevertheless, their role in predicting metastasis in early-stage CRC is uncle
Externí odkaz:
https://doaj.org/article/217f5e9dbc8c4b8c9d80fdec8923ab21
Publikováno v:
Cells, Vol 12, Iss 4, p 631 (2023)
This review summarizes recent development in synthetic drugs and biologics targeting intracellular driver genes in epithelial cancers, focusing on KRAS, and provides a current perspective and potential leads for the field. Compared to biologics, smal
Externí odkaz:
https://doaj.org/article/29dd6a20dcea4f18bce2c56c4680cc38
Autor:
Lai Fun Thean, Wong, Michelle, Lo, Michelle, Iain Tan, Wong, Evelyn, Fei Gao, Tan, Emile, Choong Leong Tang, Peh Yean Cheah
Publikováno v:
Journal of Medical Genetics; Mar2024, Vol. 61 Issue 3, p276-283, 8p
Autor:
Patrick T. Reilly, Jürgen Ruland, Kiat Hon Lim, Min Hoe Chew, Peh Yean Cheah, Hanna Bergmann, Sze Huey Tan, Vonny I. Leo
Supplemental Figure S1. Small intestinal tumorigenesis data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c95dc9e057050edbdc7d485771f99b
https://doi.org/10.1158/2326-6066.22537630
https://doi.org/10.1158/2326-6066.22537630
Autor:
Patrick T. Reilly, Jürgen Ruland, Kiat Hon Lim, Min Hoe Chew, Peh Yean Cheah, Hanna Bergmann, Sze Huey Tan, Vonny I. Leo
Caspase recuitment domain–containing protein 9 (CARD9) functions in different inflammation pathways to elicit responses to microbial signals and is known to affect intestinal inflammation. Examining the APCmin mouse model of intestinal tumorigenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::618d9fa0a2cbf4db8cded5f2ef6b6e8f
https://doi.org/10.1158/2326-6066.c.6548503.v1
https://doi.org/10.1158/2326-6066.c.6548503.v1
Autor:
Patrick T. Reilly, Jürgen Ruland, Kiat Hon Lim, Min Hoe Chew, Peh Yean Cheah, Hanna Bergmann, Sze Huey Tan, Vonny I. Leo
Supplemental Table S1 and Figure Legends for Figures S1 and S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161114d7444885eea6bc57343b7ecb79
https://doi.org/10.1158/2326-6066.22537621.v1
https://doi.org/10.1158/2326-6066.22537621.v1
Autor:
Lai Fun Thean, Yu Hui Wong, Michelle Lo, Carol Loi, Min Hoe Chew, Choong Leong Tang, Peh Yean Cheah
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173772 (2017)
Familial adenomatous polyposis (FAP) is an autosomal-dominantly inherited form of colorectal cancer (CRC) caused by mutation in the adenomatous polyposis coli (APC) gene. Our ability to exhaustively screen for APC mutations identify microsatellite-st
Externí odkaz:
https://doaj.org/article/93ba3a4f5f3447e7bd57aca154cdeed9
Autor:
Peh Yean Cheah, Kuen Kuen Lam, Yee Syuen Low, Michelle Lo, Michelle Wong, Choong Leong Tang, Emile Tan, Aik Yong Chok, Issac Seow En, Siew Heng Wong
Publikováno v:
Cancer Research. 83:4119-4119
Worldwide, colorectal cancer (CRC) is the third highest incidence cancer and a leading cause of cancer mortality. Metastasis to distal organ is the major cause of cancer mortality. However, chemotherapeutic treatment of metastatic CRC has a dismayed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc1af2ecb308807d9de72978ab096c53
https://doi.org/10.1158/1538-7445.am2023-4119
https://doi.org/10.1158/1538-7445.am2023-4119