Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.

Autor: Aung T; Singapore Eye Research Institute, Singapore.; Singapore National Eye Center, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ozaki M; Ozaki Eye Hospital, Hyuga, Miyazaki, Japan.; Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Lee MC; Singapore Eye Research Institute, Singapore.; Academic Clinical Program for Ophthalmology and Visual Sciences, Office of Clinical and Academic Faculty Affairs, Duke-NUS Graduate Medical School, Singapore., Schlötzer-Schrehardt U; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Thorleifsson G; deCODE Genetics, Reykjavik, Iceland., Mizoguchi T; Mizoguchi Eye Hospital, Sasebo, Japan., Igo RP Jr; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Haripriya A; Aravind Eye Hospital, Madurai, India., Williams SE; Division of Ophthalmology, University of the Witwatersrand, Johannesburg, South Africa., Astakhov YS; Department of Ophthalmology, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia., Orr AC; Department of Ophthalmology, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada., Burdon KP; Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia.; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Nakano S; Department of Ophthalmology, Oita University Faculty of Medicine, Oita, Japan., Mori K; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Abu-Amero K; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.; Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, Florida, USA., Hauser M; Singapore Eye Research Institute, Singapore.; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA.; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Li Z; Genome Institute of Singapore, Singapore., Prakadeeswari G; Department of Genetics, Aravind Medical Research Foundation, Madurai, India., Bailey JNC; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Cherecheanu AP; 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania.; Department of Ophthalmology, University Emergency Hospital, Bucharest, Romania., Kang JH; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Nelson S; Department of Biostatistics, University of Washington, Seattle, Washington, USA., Hayashi K; Hayashi Eye Hospital, Fukuoka, Japan., Manabe SI; Hayashi Eye Hospital, Fukuoka, Japan., Kazama S; Shinjo Eye Clinic, Miyazaki, Japan., Zarnowski T; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Inoue K; Inoue Eye Hospital, Tokyo, Japan., Irkec M; Department of Ophthalmology, Hacettepe University, Faculty of Medicine, Ankara, Turkey., Coca-Prados M; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain.; Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA., Sugiyama K; Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan., Järvelä I; Department of Medical Genetics, University of Helsinki, Helsinki, Finland., Schlottmann P; Organización Médica de Investigación, Buenos Aires, Argentina., Lerner SF; Fundación para el Estudio del Glaucoma, Buenos Aires, Argentina., Lamari H; Clinique Spécialisée en Ophtalmologie Mohammedia, Mohammedia, Morocco., Nilgün Y; Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey., Bikbov M; Ufa Eye Research Institute, Ufa, Russia., Park KH; Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Cha SC; Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Republic of Korea., Yamashiro K; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of Ophthalmology, Otsu Red Cross Hospital, Otsu, Japan., Zenteno JC; Genetics Department, Institute of Ophthalmology 'Conde de Valenciana', Mexico City, Mexico.; Biochemistry Department, Faculty of Medicine, UNAM, Mexico City, Mexico., Jonas JB; Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht Karls University of Heidelberg, Mannheim, Germany.; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Kumar RS; Narayana Nethralaya Eye Hospital, Bangalore, India., Perera SA; Singapore Eye Research Institute, Singapore.; Singapore National Eye Center, Singapore., Chan ASY; Singapore Eye Research Institute, Singapore.; Singapore National Eye Center, Singapore.; Academic Clinical Program for Ophthalmology and Visual Sciences, Office of Clinical and Academic Faculty Affairs, Duke-NUS Graduate Medical School, Singapore., Kobakhidze N; Chichua Medical Center Mzera, LLC, Tbilisi, Georgia., George R; Jadhavbhai Nathamal Singhvi Department of Glaucoma, Medical Research Foundation, Chennai, India., Vijaya L; Jadhavbhai Nathamal Singhvi Department of Glaucoma, Medical Research Foundation, Chennai, India., Do T; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Edward DP; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.; Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA., de Juan Marcos L; Department of Ophthalmology, University Hospital of Salamanca, Salamanca, Spain.; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain., Pakravan M; Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Moghimi S; Farabi Eye Hospital, Tehran University Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran., Ideta R; Ideta Eye Hospital, Kumamoto City, Japan., Bach-Holm D; Eye Clinic, Rigshospitalet-Glostrup, Glostrup, Denmark., Kappelgaard P; Eye Clinic, Rigshospitalet-Glostrup, Glostrup, Denmark., Wirostko B; John A. Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Thomas S; John A. Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Gaston D; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada., Bedard K; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada., Greer WL; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada., Yang Z; Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.; School of Medicine, University of Electronic Science and Technology of China, Chengdu, China., Chen X; Department of Ophthalmology, First Affiliated Hospital of Xinjiang Medical University, Urumchi, China., Huang L; Center for Human Molecular Biology and Genetics, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China.; Sichuan Translational Research Hospital, Chinese Academy of Sciences, Chengdu, China., Sang J; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Jia H; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Jia L; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Qiao C; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Zhang H; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Liu X; Shenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital, Jinan University, Shenzhen, China., Zhao B; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wang YX; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Xu L; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Leruez S; Département d'Ophtalmologie, Centre Hospitalier Universitaire, Angers, France., Reynier P; Département de Biochimie et Génétique, Centre Hospitalier Universitaire, Angers, France., Chichua G; Chichua Medical Center Mzera, LLC, Tbilisi, Georgia., Tabagari S; David Tvildiani Medical University, Tbilisi, Georgia., Uebe S; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Zenkel M; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Berner D; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Mossböck G; Department of Ophthalmology, Medical University Graz, Graz, Austria., Weisschuh N; Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tübingen, Tübingen, Germany., Hoja U; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Welge-Luessen UC; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Mardin C; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Founti P; Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Chatzikyriakidou A; Laboratory of General Biology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Pappas T; Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Anastasopoulos E; Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Lambropoulos A; Laboratory of General Biology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Ghosh A; GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, India., Shetty R; Narayana Nethralaya Eye Hospital, Bangalore, India., Porporato N; Santa Lucia Eye Hospital from Buenos Aires, Buenos Aires, Argentina., Saravanan V; Department of Genetics, Aravind Medical Research Foundation, Madurai, India., Venkatesh R; Aravind Eye Hospital, Pondicherry, India., Shivkumar C; Aravind Eye Hospital, Tirunelveli, India., Kalpana N; Aravind Eye Hospital, Coimbatore, India., Sarangapani S; Vision Research Foundation, Chennai, India., Kanavi MR; Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Beni AN; Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Yazdani S; Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Lashay A; Farabi Eye Hospital, Tehran University Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran., Naderifar H; Farabi Eye Hospital, Tehran University Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran., Khatibi N; Farabi Eye Hospital, Tehran University Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran., Fea A; Dipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy., Lavia C; Dipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy., Dallorto L; Dipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy., Rolle T; Dipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy., Frezzotti P; Ophthalmology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy., Paoli D; Department of Ophthalmology, Monfalcone Hospital, Gorizia, Italy., Salvi E; Department of Health Sciences, University of Milan, Milan, Italy., Manunta P; Department of Nephrology, University Vita-Salute San Raffaele, Milan, Italy., Mori Y; Miyata Eye Hospital, Miyazaki, Japan., Miyata K; Miyata Eye Hospital, Miyazaki, Japan., Higashide T; Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan., Chihara E; Sensho-kai Eye Institute, Kyoto, Japan., Ishiko S; Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University, Asahikawa, Japan., Yoshida A; Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan., Yanagi M; Department of Ophthalmology and Visual Sciences, Hiroshima University, Hiroshima, Japan., Kiuchi Y; Department of Ophthalmology and Visual Sciences, Hiroshima University, Hiroshima, Japan., Ohashi T; Ohashi Eye Center, Sapporo, Japan., Sakurai T; Tane Memorial Eye Hospital, Osaka, Japan., Sugimoto T; Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Chuman H; Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Aihara M; Department of Ophthalmology, University of Tokyo, Tokyo, Japan., Inatani M; Department of Ophthalmology, Faculty of Medical Science, University of Fukui, Fukui, Japan., Miyake M; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan., Gotoh N; Center for Genomic Medicine, INSERM U852, Kyoto University Graduate School of Medicine, Kyoto, Japan., Matsuda F; Center for Genomic Medicine, INSERM U852, Kyoto University Graduate School of Medicine, Kyoto, Japan., Yoshimura N; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan., Ikeda Y; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Ueno M; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Sotozono C; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Jeoung JW; Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Sagong M; Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Republic of Korea., Park KH; Department of Ophthalmology, Seoul National University Bundang Hospital, Gyeonggi, Republic of Korea., Ahn J; Department of Ophthalmology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea., Cruz-Aguilar M; Genetics Department, Institute of Ophthalmology 'Conde de Valenciana', Mexico City, Mexico., Ezzouhairi SM; Clinique Spécialisée en Ophtalmologie Mohammedia, Mohammedia, Morocco., Rafei A; Laboratoires RAFEI, Mohammedia, Morocco., Chong YF; Singapore Eye Research Institute, Singapore., Ng XY; Singapore Eye Research Institute, Singapore., Goh SR; Singapore Eye Research Institute, Singapore., Chen Y; Singapore Eye Research Institute, Singapore., Yong VHK; Singapore Eye Research Institute, Singapore., Khan MI; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands., Olawoye OO; Department of Ophthalmology, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Department of Ophthalmology, University College Hospital, Ibadan, Nigeria., Ashaye AO; Department of Ophthalmology, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Department of Ophthalmology, University College Hospital, Ibadan, Nigeria., Ugbede I; ECWA Eye Hospital, Kano, Nigeria., Onakoya A; Department of Ophthalmology, University of Lagos, Lagos, Nigeria.; Guinness Eye Centre, Lagos University Teaching Hospital, Lagos, Nigeria., Kizor-Akaraiwe N; Department of Ophthalmology, ESUT Teaching Hospital Parklane, Enugu, Nigeria.; Eye Specialists Hospital, Enugu, Nigeria., Teekhasaenee C; Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Suwan Y; Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Supakontanasan W; Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Okeke S; Department of Ophthalmology, ESUT Teaching Hospital Parklane, Enugu, Nigeria.; Eye Specialists Hospital, Enugu, Nigeria., Uche NJ; Eye Specialists Hospital, Enugu, Nigeria.; Department of Ophthalmology, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.; Department of Ophthalmology, College of Medicine, University of Nigeria, Nsukka, Ituku Ozalla Campus, Enugu, Nigeria., Asimadu I; Department of Ophthalmology, ESUT Teaching Hospital Parklane, Enugu, Nigeria., Ayub H; Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan., Akhtar F; Pakistan Institute of Ophthalmology, Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan., Kosior-Jarecka E; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Lukasik U; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Lischinsky I; Centro Oftalmologico Lischinsky, Tucumán, Argentina., Castro V; Universidad Peruana Cayetano Heredia, Hospital Nacional Arzobispo Loayza, Lima, Peru., Grossmann RP; Instituto de Glaucoma y Catarata, Lima, Peru., Sunaric Megevand G; Clinical Research Centre Adolphe de Rothschild, Société Médicale de Beaulieu, Geneva, Switzerland., Roy S; Clinical Research Centre Adolphe de Rothschild, Société Médicale de Beaulieu, Geneva, Switzerland., Dervan E; Mater Misericordiae University Hospital, Dublin, Ireland., Silke E; Mater Misericordiae University Hospital, Dublin, Ireland., Rao A; Shri Mithu Tulsi, LV Prasad Eye Institute, Bhubaneswar, India., Sahay P; Shri Mithu Tulsi, LV Prasad Eye Institute, Bhubaneswar, India., Fornero P; Hospital Córdoba, Córdoba, Argentina., Cuello O; Hospital Córdoba, Córdoba, Argentina., Sivori D; Fundación para el Estudio del Glaucoma, Buenos Aires, Argentina., Zompa T; Centro Oftalmologico Charles, Buenos Aires, Argentina., Mills RA; Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia., Souzeau E; Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia., Mitchell P; Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia., Wang JJ; Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia., Hewitt AW; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia., Coote M; Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia., Crowston JG; Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia., Astakhov SY; Department of Ophthalmology, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia., Akopov EL; Department of Ophthalmology, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia., Emelyanov A; Department of Ophthalmology, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia.; St. Petersburg Academic University, St. Petersburg, Russia., Vysochinskaya V; St. Petersburg Academic University, St. Petersburg, Russia., Kazakbaeva G; Ufa Eye Research Institute, Ufa, Russia., Fayzrakhmanov R; Ufa Eye Research Institute, Ufa, Russia., Al-Obeidan SA; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Owaidhah O; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia., Aljasim LA; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia., Chowbay B; Clinical Pharmacology, SingHealth, Singapore.; Clinical Pharmacology Laboratory, National Cancer Centre, Singapore.; Office of Clinical Sciences, Duke-NUS Medical School, Singapore., Foo JN; Genome Institute of Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore., Soh RQ; Genome Institute of Singapore, Singapore., Sim KS; Genome Institute of Singapore, Singapore., Xie Z; Genome Institute of Singapore, Singapore., Cheong AWO; Genome Institute of Singapore, Singapore., Mok SQ; Genome Institute of Singapore, Singapore., Soo HM; Genome Institute of Singapore, Singapore., Chen XY; Genome Institute of Singapore, Singapore., Peh SQ; Genome Institute of Singapore, Singapore., Heng KK; Genome Institute of Singapore, Singapore., Husain R; Singapore National Eye Center, Singapore., Ho SL; Department of Ophthalmology, Tan Tock Seng Hospital, Singapore., Hillmer AM; Genome Institute of Singapore, Singapore., Cheng CY; Singapore Eye Research Institute, Singapore.; Singapore National Eye Center, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Academic Clinical Program for Ophthalmology and Visual Sciences, Office of Clinical and Academic Faculty Affairs, Duke-NUS Graduate Medical School, Singapore., Escudero-Domínguez FA; Department of Ophthalmology, University Hospital of Salamanca, Salamanca, Spain., González-Sarmiento R; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.; Molecular Medicine Unit, Department of Medicine, University of Salamanca, Salamanca, Spain., Martinon-Torres F; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain.; GENVIP Research Group, Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, Spain., Salas A; Unidade de Xenética, Departamento de Anatomía Patolóxica e Ciencias Forenses, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Pathanapitoon K; Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Hansapinyo L; Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Wanichwecharugruang B; Department of Ophthalmology, Rajavithi Hospital, Bangkok, Thailand., Kitnarong N; Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand., Sakuntabhai A; Institut Pasteur, Functional Genetics of Infectious Diseases Unit, Department of Genomes and Genetics, Paris, France.; Centre National de la Recherche Scientifique, Unité de Recherche Associée 3012, Paris, France., Nguyn HX; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Nguyn GTT; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Nguyn TV; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Zenz W; Department of General Pediatrics, Medical University of Graz, Graz, Austria., Binder A; Department of General Pediatrics, Medical University of Graz, Graz, Austria., Klobassa DS; Department of General Pediatrics, Medical University of Graz, Graz, Austria., Hibberd ML; Genome Institute of Singapore, Singapore.; Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, UK., Davila S; Genome Institute of Singapore, Singapore., Herms S; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Division of Medical Genetics, University Hospital Basel, Basel, Switzerland., Nöthen MM; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.; Institute of Human Genetics, University of Bonn, Bonn, Germany., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Rautenbach RM; Division of Ophthalmology, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa., Ziskind A; Division of Ophthalmology, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa., Carmichael TR; Division of Ophthalmology, University of the Witwatersrand, Johannesburg, South Africa., Ramsay M; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Álvarez L; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., García M; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., González-Iglesias H; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., Rodríguez-Calvo PP; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., Fernández-Vega Cueto L; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., Oguz Ç; Department of Genetics, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey., Tamcelik N; Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey., Atalay E; Singapore Eye Research Institute, Singapore.; Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey., Batu B; Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey., Aktas D; DAMAGEN Genetic Diagnostic Center, Ankara, Turkey., Kasım B; Department of Ophthalmology, Hacettepe University, Faculty of Medicine, Ankara, Turkey., Wilson MR; School of Medicine, Wayne State University, Detroit, Michigan, USA., Coleman AL; Center for Community Outreach and Policy, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA., Liu Y; Department of Cellular Biology and Anatomy, Center for Biotechnology and Genomic Medicine, James and Jean Culver Discovery Institute, Augusta University, Augusta, Georgia, USA., Challa P; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA., Herndon L; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA., Kuchtey RW; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Kuchtey J; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Curtin K; John A. Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Chaya CJ; John A. Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Crandall A; John A. Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Zangwill LM; Hamilton Glaucoma Center, Department of Ophthalmology and Shiley Eye Institute, University of California, San Diego, San Diego, California, USA., Wong TY; Singapore Eye Research Institute, Singapore.; Singapore National Eye Center, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Nakano M; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kinoshita S; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.; Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., den Hollander AI; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands.; Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands., Vesti E; Department of Ophthalmology, University of Turku and Turku University Hospital, Turku, Finland., Fingert JH; Institute for Vision Research, University of Iowa, Iowa City, Iowa, USA.; Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Lee RK; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA., Sit AJ; Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA., Shingleton BJ; Ophthalmic Consultants of Boston, Boston, Massachusetts, USA., Wang N; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Cusi D; Institute of Biomedical Technologies, Italian National Research Centre (ITB-CNR), Segrate-Milano, Italy., Qamar R; Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.; Department of Biochemistry, Al-Nafees Medical College and Hospital, Isra University, Islamabad, Pakistan., Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Raychaudhuri S; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Institute of Inflammation and Repair, University of Manchester, Manchester, UK.; Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden., Heegaard S; Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Department of Pathology, Rigshospitalet, Eye Pathology Section, University of Copenhagen, Copenhagen, Denmark., Kivelä T; Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Reis A; David Tvildiani Medical University, Tbilisi, Georgia., Kruse FE; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Weinreb RN; Hamilton Glaucoma Center, Department of Ophthalmology and Shiley Eye Institute, University of California, San Diego, San Diego, California, USA., Pasquale LR; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA., Haines JL; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.; Institute of Computational Biology, Case Western Reserve University, Cleveland, Ohio, USA., Thorsteinsdottir U; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Jonasson F; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Ophthalmology, Landspitali University Hospital, Reykjavik, Iceland., Allingham RR; Singapore Eye Research Institute, Singapore.; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA., Milea D; Singapore Eye Research Institute, Singapore.; Singapore National Eye Center, Singapore.; Academic Clinical Program for Ophthalmology and Visual Sciences, Office of Clinical and Academic Faculty Affairs, Duke-NUS Graduate Medical School, Singapore., Ritch R; Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA., Kubota T; Department of Ophthalmology, Oita University Faculty of Medicine, Oita, Japan., Tashiro K; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Vithana EN; Singapore Eye Research Institute, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Micheal S; Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands., Topouzis F; Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Craig JE; Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia., Dubina M; Department of Ophthalmology, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia.; St. Petersburg Academic University, St. Petersburg, Russia., Sundaresan P; Dr. G.Venkataswamy Eye Research Institute, Aravind Medical Research Foundation, Aravind Eye Hospital, Madurai, India., Stefansson K; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Wiggs JL; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA., Pasutto F; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Khor CC; Singapore Eye Research Institute, Singapore.; Genome Institute of Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Publikováno v: Nature genetics [Nat Genet] 2017 Jul; Vol. 49 (7), pp. 993-1004. Date of Electronic Publication: 2017 May 29.

A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.

Autor: Aung T; 1] Singapore Eye Research Institute, Singapore. [2] Singapore National Eye Center, Singapore. [3] Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. [4] Division of Human Genetics, Genome Institute of Singapore, Singapore. [5] Duke University-National University of Singapore Graduate Medical School, Singapore., Ozaki M; 1] Ozaki Eye Hospital, Hyuga, Japan. [2] Hayashi Eye Hospital, Fukuoka, Japan., Mizoguchi T; Mizoguchi Eye Hospital, Sasebo, Japan., Allingham RR; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA., Li Z; Division of Human Genetics, Genome Institute of Singapore, Singapore., Haripriya A; Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India., Nakano S; Department of Ophthalmology, Oita University Faculty of Medicine, Oita, Japan., Uebe S; Institute of Human Genetics, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany., Harder JM; Howard Hughes Medical Institute, Jackson Laboratory, Bar Harbor, Maine, USA., Chan AS; 1] Singapore Eye Research Institute, Singapore. [2] Singapore National Eye Center, Singapore., Lee MC; Singapore Eye Research Institute, Singapore., Burdon KP; 1] Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia. [2] Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Astakhov YS; Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia., Abu-Amero KK; 1] Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. [2] Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, Florida, USA., Zenteno JC; 1] Department of Genetics, Institute of Ophthalmology Conde de Valenciana, Mexico City, Mexico. [2] Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico., Nilgün Y; Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Turkey., Zarnowski T; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Pakravan M; Department of Ophthalmology, Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Safieh LA; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia., Jia L; Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wang YX; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China., Williams S; Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa., Paoli D; Department of Ophthalmology, Monfalcone Hospital, Gorizia, Italy., Schlottmann PG; Organización Médica de Investigación, Buenos Aires, Argentina., Huang L; 1] Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China. [2] School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. [3] Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China., Sim KS; Division of Human Genetics, Genome Institute of Singapore, Singapore., Foo JN; Division of Human Genetics, Genome Institute of Singapore, Singapore., Nakano M; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Ikeda Y; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kumar RS; Glaucoma Services, Narayana Nethralaya Eye Hospital, Bangalore, India., Ueno M; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Manabe S; Hayashi Eye Hospital, Fukuoka, Japan., Hayashi K; Hayashi Eye Hospital, Fukuoka, Japan., Kazama S; Shinjo Eye Clinic, Miyazaki, Japan., Ideta R; Ideta Eye Hospital, Kumamoto, Japan., Mori Y; Miyata Eye Hospital, Miyazaki, Japan., Miyata K; 1] Miyata Eye Hospital, Miyazaki, Japan. [2] Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Sugiyama K; Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan., Higashide T; Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan., Chihara E; Sensho-kai Eye Institute, Kyoto, Japan., Inoue K; Inouye Eye Hospital, Tokyo, Japan., Ishiko S; Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University, Asahikawa, Japan., Yoshida A; Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan., Yanagi M; Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan., Kiuchi Y; Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan., Aihara M; Yotsuya Shirato Eye Clinic, Tokyo, Japan., Ohashi T; Ohashi Eye Center, Sapporo, Japan., Sakurai T; Tane Memorial Eye Hospital, Osaka, Japan., Sugimoto T; Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Chuman H; Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Matsuda F; Center for Genomic Medicine/INSERM U852, Kyoto University Graduate School of Medicine, Kyoto, Japan., Yamashiro K; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan., Gotoh N; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan., Miyake M; 1] Center for Genomic Medicine/INSERM U852, Kyoto University Graduate School of Medicine, Kyoto, Japan. [2] Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan., Astakhov SY; Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia., Osman EA; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Al-Obeidan SA; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Owaidhah O; Department of Ophthalmology, Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Al-Jasim L; Department of Ophthalmology, Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Al Shahwan S; Department of Ophthalmology, Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Fogarty RA; Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia., Leo P; University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia., Yetkin Y; Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Turkey., Oğuz Ç; Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Turkey., Kanavi MR; Department of Ophthalmology, Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Beni AN; Department of Ophthalmology, Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Yazdani S; Department of Ophthalmology, Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Akopov EL; Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia., Toh KY; Division of Human Genetics, Genome Institute of Singapore, Singapore., Howell GR; Howard Hughes Medical Institute, Jackson Laboratory, Bar Harbor, Maine, USA., Orr AC; Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada., Goh Y; Division of Human Genetics, Genome Institute of Singapore, Singapore., Meah WY; Division of Human Genetics, Genome Institute of Singapore, Singapore., Peh SQ; Division of Human Genetics, Genome Institute of Singapore, Singapore., Kosior-Jarecka E; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Lukasik U; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Krumbiegel M; Institute of Human Genetics, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany., Vithana EN; Singapore Eye Research Institute, Singapore., Wong TY; 1] Singapore Eye Research Institute, Singapore. [2] Singapore National Eye Center, Singapore. [3] Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Liu Y; 1] Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA. [2] Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, Georgia, USA., Koch AE; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Challa P; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA., Rautenbach RM; Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa., Mackey DA; Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia., Hewitt AW; 1] Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. [2] Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia., Mitchell P; Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia., Wang JJ; Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia., Ziskind A; Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa., Carmichael T; Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa., Ramakrishnan R; Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India., Narendran K; Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India., Venkatesh R; Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India., Vijayan S; Department of Genetics, Aravind Medical Research Foundation, Madurai, India., Zhao P; Department of Ophthalmology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, China., Chen X; Department of Ophthalmology, First Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang Uygur Autonomous Region, China., Guadarrama-Vallejo D; 1] Department of Genetics, Institute of Ophthalmology Conde de Valenciana, Mexico City, Mexico. [2] Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico., Cheng CY; 1] Singapore Eye Research Institute, Singapore. [2] Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Perera SA; 1] Singapore Eye Research Institute, Singapore. [2] Singapore National Eye Center, Singapore., Husain R; 1] Singapore Eye Research Institute, Singapore. [2] Singapore National Eye Center, Singapore., Ho SL; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore., Welge-Luessen UC; Department of Ophthalmology, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany., Mardin C; Department of Ophthalmology, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany., Schloetzer-Schrehardt U; Department of Ophthalmology, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany., Hillmer AM; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore., Herms S; 1] Institute of Human Genetics, University of Bonn, Bonn, Germany. [2] Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany. [3] Division of Medical Genetics, University Hospital, Basel, Switzerland. [4] Human Genetics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Nöthen MM; 1] Institute of Human Genetics, University of Bonn, Bonn, Germany. [2] Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany., Weisschuh N; Institute for Ophthalmic Research, Department of Ophthalmology, Tübingen, Germany., Shetty R; Glaucoma Services, Narayana Nethralaya Eye Hospital, Bangalore, India., Ghosh A; 1] Singapore Eye Research Institute, Singapore. [2] Genes, Repair and Regeneration in Ophthalmic Workstation Research Laboratory, Narayana Nethralaya Foundation, Bangalore, India., Teo YY; 1] Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA. [2] Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Brown MA; University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia., Lischinsky I; Centro Oftalmológico Lischinsky, Tucumán, Argentina., Crowston JG; 1] Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia. [2] Department of Ophthalmology, University of Melbourne, Melbourne, Victoria, Australia., Coote M; 1] Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia. [2] Department of Ophthalmology, University of Melbourne, Melbourne, Victoria, Australia., Zhao B; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia., Sang J; Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Zhang N; Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China., You Q; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China., Vysochinskaya V; St. Petersburg Academic University, St. Petersburg, Russia., Founti P; Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, American Hellenic Educational Progressive Association Hospital, Thessaloniki, Greece., Chatzikyriakidou A; Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Lambropoulos A; Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Anastasopoulos E; Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, American Hellenic Educational Progressive Association Hospital, Thessaloniki, Greece., Coleman AL; Center for Community Outreach and Policy, Stein Eye Institute, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA., Wilson MR; Wayne State University, Detroit, Michigan, USA., Rhee DJ; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA., Kang JH; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., May-Bolchakova I; Department of Ophthalmology, Military Hospital Begin, Paris, France., Heegaard S; 1] Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark. [2] Department of Ophthalmology, Glostrup University Hospital, Glostrup, Denmark., Mori K; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Alward WL; 1] Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, Iowa, USA. [2] Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Jonas JB; Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht Karls University Heidelberg, Heidelberg, Germany., Xu L; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China., Liebmann JM; New York University School of Medicine, Manhattan Eye, Ear and Throat Hospital, New York, New York, USA., Chowbay B; Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre of Singapore, Singapore., Schaeffeler E; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany., Schwab M; 1] Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany. [2] Department of Clinical Pharmacology, University Hospital, Tübingen, Germany. [3] German Cancer Consortium (DKTK), German Cancer Research Center, Heidelberg, Germany., Lerner F; Fundación para el Estudio del Glaucoma, Buenos Aires, Argentina., Wang N; Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Yang Z; 1] Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China. [2] School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. [3] Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China., Frezzotti P; Department of Surgery, Section of Ophthalmology, University of Siena, Siena, Italy., Kinoshita S; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Fingert JH; 1] Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, Iowa, USA. [2] Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Inatani M; Department of Ophthalmology, Faculty of Medical Science, University of Fukui, Fukui, Japan., Tashiro K; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Reis A; Institute of Human Genetics, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany., Edward DP; 1] King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. [2] Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Pasquale LR; 1] Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Kubota T; Department of Ophthalmology, Oita University Faculty of Medicine, Oita, Japan., Wiggs JL; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA., Pasutto F; Institute of Human Genetics, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany., Topouzis F; Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, American Hellenic Educational Progressive Association Hospital, Thessaloniki, Greece., Dubina M; 1] Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia. [2] St. Petersburg Academic University, St. Petersburg, Russia., Craig JE; Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia., Yoshimura N; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan., Sundaresan P; Department of Genetics, Aravind Medical Research Foundation, Madurai, India., John SW; Howard Hughes Medical Institute, Jackson Laboratory, Bar Harbor, Maine, USA., Ritch R; Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA., Hauser MA; 1] Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA. [2] Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Khor CC; 1] Singapore Eye Research Institute, Singapore. [2] Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. [3] Division of Human Genetics, Genome Institute of Singapore, Singapore.

Publikováno v: Nature genetics [Nat Genet] 2015 Apr; Vol. 47 (4), pp. 387-92. Date of Electronic Publication: 2015 Feb 23.

ChIA-PET analysis of transcriptional chromatin interactions.

Autor: Zhang J; Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore., Poh HM, Peh SQ, Sia YY, Li G, Mulawadi FH, Goh Y, Fullwood MJ, Sung WK, Ruan X, Ruan Y

Publikováno v: Methods (San Diego, Calif.) [Methods] 2012 Nov; Vol. 58 (3), pp. 289-99. Date of Electronic Publication: 2012 Aug 25.

Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation.

Autor: Li G; Genome Institute of Singapore, Singapore 138672, Republic of Singapore., Ruan X, Auerbach RK, Sandhu KS, Zheng M, Wang P, Poh HM, Goh Y, Lim J, Zhang J, Sim HS, Peh SQ, Mulawadi FH, Ong CT, Orlov YL, Hong S, Zhang Z, Landt S, Raha D, Euskirchen G, Wei CL, Ge W, Wang H, Davis C, Fisher-Aylor KI, Mortazavi A, Gerstein M, Gingeras T, Wold B, Sun Y, Fullwood MJ, Cheung E, Liu E, Sung WK, Snyder M, Ruan Y

Publikováno v: Cell [Cell] 2012 Jan 20; Vol. 148 (1-2), pp. 84-98.