A five-safes approach to a secure and scalable genomics data repository.

Autor: Shih CC; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Chen J; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Lee AS; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Bertin N; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Hebrard M; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Khor CC; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore., Li Z; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Juan Tan JH; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Meah WY; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Peh SQ; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Mok SQ; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Sim KS; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Liu J; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore., Wang L; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Wong E; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Li J; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore., Tin A; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Duke-NUS Medical School, Singapore, Republic of Singapore.; Singapore National Eye Centre, Singapore, Republic of Singapore., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore.; Duke-NUS Medical School, Singapore, Republic of Singapore., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Republic of Singapore., Yuan JM; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore 117609, Republic of Singapore., Saw SM; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore.; Duke-NUS Medical School, Singapore, Republic of Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Republic of Singapore., Friedlander Y; Braun School of Public Health, Hebrew University of Jerusalem, Jerusalem, Israel., Sim X; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Republic of Singapore., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Republic of Singapore., Chong YS; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore 117609, Republic of Singapore., Davila S; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, Republic of Singapore., Goh LL; Molecular Diagnostic Laboratory, Tan Tock Seng Hospital, Singapore, Republic of Singapore., Lee ES; Clinical Research Unit, National Healthcare Group Polyclinics, Singapore, Republic of Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Republic of Singapore., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore.; Duke-NUS Medical School, Singapore, Republic of Singapore.; Singapore National Eye Centre, Singapore, Republic of Singapore., Karnani N; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore 117609, Republic of Singapore.; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A∗STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Republic of Singapore., Leong KP; Personalised Medicine Service, Tan Tock Seng Hospital, Singapore, Republic of Singapore., Yeo KK; Duke-NUS Medical School, Singapore, Republic of Singapore.; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, Republic of Singapore.; Department of Cardiology, National Heart Centre Singapore, Singapore, Republic of Singapore., Chambers JC; Precision Health Research, Singapore, Republic of Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Republic of Singapore.; School of Public Health, Imperial College London, London, UK., Lim SC; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Republic of Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Republic of Singapore.; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore.; Diabetes Centre, Admiralty Medical Centre, Singapore, Republic of Singapore., Goh RSM; Institute of High Performance Computing (IHPC), Agency for Science, Technology and Research (A∗STAR), 1 Fusionopolis Way, #16-16 Connexis (North Tower), Singapore 138632, Republic of Singapore., Tan P; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore.; Duke-NUS Medical School, Singapore, Republic of Singapore.; Precision Health Research, Singapore, Republic of Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Republic of Singapore., Dorajoo R; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A∗STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Republic of Singapore.; Duke-NUS Medical School, Singapore, Republic of Singapore.

Publikováno v: IScience [iScience] 2023 Mar 31; Vol. 26 (4), pp. 106546. Date of Electronic Publication: 2023 Mar 31 (Print Publication: 2023).

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.

Autor: Aung T; Singapore Eye Research Institute, Singapore.; Singapore National Eye Center, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ozaki M; Ozaki Eye Hospital, Hyuga, Miyazaki, Japan.; Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Lee MC; Singapore Eye Research Institute, Singapore.; Academic Clinical Program for Ophthalmology and Visual Sciences, Office of Clinical and Academic Faculty Affairs, Duke-NUS Graduate Medical School, Singapore., Schlötzer-Schrehardt U; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Thorleifsson G; deCODE Genetics, Reykjavik, Iceland., Mizoguchi T; Mizoguchi Eye Hospital, Sasebo, Japan., Igo RP Jr; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Haripriya A; Aravind Eye Hospital, Madurai, India., Williams SE; Division of Ophthalmology, University of the Witwatersrand, Johannesburg, South Africa., Astakhov YS; Department of Ophthalmology, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia., Orr AC; Department of Ophthalmology, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada., Burdon KP; Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia.; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Nakano S; Department of Ophthalmology, Oita University Faculty of Medicine, Oita, Japan., Mori K; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Abu-Amero K; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.; Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, Florida, USA., Hauser M; Singapore Eye Research Institute, Singapore.; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA.; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Li Z; Genome Institute of Singapore, Singapore., Prakadeeswari G; Department of Genetics, Aravind Medical Research Foundation, Madurai, India., Bailey JNC; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Cherecheanu AP; 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania.; Department of Ophthalmology, University Emergency Hospital, Bucharest, Romania., Kang JH; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Nelson S; Department of Biostatistics, University of Washington, Seattle, Washington, USA., Hayashi K; Hayashi Eye Hospital, Fukuoka, Japan., Manabe SI; Hayashi Eye Hospital, Fukuoka, Japan., Kazama S; Shinjo Eye Clinic, Miyazaki, Japan., Zarnowski T; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Inoue K; Inoue Eye Hospital, Tokyo, Japan., Irkec M; Department of Ophthalmology, Hacettepe University, Faculty of Medicine, Ankara, Turkey., Coca-Prados M; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain.; Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA., Sugiyama K; Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan., Järvelä I; Department of Medical Genetics, University of Helsinki, Helsinki, Finland., Schlottmann P; Organización Médica de Investigación, Buenos Aires, Argentina., Lerner SF; Fundación para el Estudio del Glaucoma, Buenos Aires, Argentina., Lamari H; Clinique Spécialisée en Ophtalmologie Mohammedia, Mohammedia, Morocco., Nilgün Y; Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey., Bikbov M; Ufa Eye Research Institute, Ufa, Russia., Park KH; Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Cha SC; Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Republic of Korea., Yamashiro K; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of Ophthalmology, Otsu Red Cross Hospital, Otsu, Japan., Zenteno JC; Genetics Department, Institute of Ophthalmology 'Conde de Valenciana', Mexico City, Mexico.; Biochemistry Department, Faculty of Medicine, UNAM, Mexico City, Mexico., Jonas JB; Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht Karls University of Heidelberg, Mannheim, Germany.; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Kumar RS; Narayana Nethralaya Eye Hospital, Bangalore, India., Perera SA; Singapore Eye Research Institute, Singapore.; Singapore National Eye Center, Singapore., Chan ASY; Singapore Eye Research Institute, Singapore.; Singapore National Eye Center, Singapore.; Academic Clinical Program for Ophthalmology and Visual Sciences, Office of Clinical and Academic Faculty Affairs, Duke-NUS Graduate Medical School, Singapore., Kobakhidze N; Chichua Medical Center Mzera, LLC, Tbilisi, Georgia., George R; Jadhavbhai Nathamal Singhvi Department of Glaucoma, Medical Research Foundation, Chennai, India., Vijaya L; Jadhavbhai Nathamal Singhvi Department of Glaucoma, Medical Research Foundation, Chennai, India., Do T; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Edward DP; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.; Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA., de Juan Marcos L; Department of Ophthalmology, University Hospital of Salamanca, Salamanca, Spain.; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain., Pakravan M; Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Moghimi S; Farabi Eye Hospital, Tehran University Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran., Ideta R; Ideta Eye Hospital, Kumamoto City, Japan., Bach-Holm D; Eye Clinic, Rigshospitalet-Glostrup, Glostrup, Denmark., Kappelgaard P; Eye Clinic, Rigshospitalet-Glostrup, Glostrup, Denmark., Wirostko B; John A. Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Thomas S; John A. Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Gaston D; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada., Bedard K; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada., Greer WL; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada., Yang Z; Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.; School of Medicine, University of Electronic Science and Technology of China, Chengdu, China., Chen X; Department of Ophthalmology, First Affiliated Hospital of Xinjiang Medical University, Urumchi, China., Huang L; Center for Human Molecular Biology and Genetics, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China.; Sichuan Translational Research Hospital, Chinese Academy of Sciences, Chengdu, China., Sang J; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Jia H; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Jia L; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Qiao C; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Zhang H; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Liu X; Shenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital, Jinan University, Shenzhen, China., Zhao B; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wang YX; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Xu L; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China., Leruez S; Département d'Ophtalmologie, Centre Hospitalier Universitaire, Angers, France., Reynier P; Département de Biochimie et Génétique, Centre Hospitalier Universitaire, Angers, France., Chichua G; Chichua Medical Center Mzera, LLC, Tbilisi, Georgia., Tabagari S; David Tvildiani Medical University, Tbilisi, Georgia., Uebe S; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Zenkel M; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Berner D; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Mossböck G; Department of Ophthalmology, Medical University Graz, Graz, Austria., Weisschuh N; Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tübingen, Tübingen, Germany., Hoja U; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Welge-Luessen UC; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Mardin C; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Founti P; Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Chatzikyriakidou A; Laboratory of General Biology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Pappas T; Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Anastasopoulos E; Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Lambropoulos A; Laboratory of General Biology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Ghosh A; GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, India., Shetty R; Narayana Nethralaya Eye Hospital, Bangalore, India., Porporato N; Santa Lucia Eye Hospital from Buenos Aires, Buenos Aires, Argentina., Saravanan V; Department of Genetics, Aravind Medical Research Foundation, Madurai, India., Venkatesh R; Aravind Eye Hospital, Pondicherry, India., Shivkumar C; Aravind Eye Hospital, Tirunelveli, India., Kalpana N; Aravind Eye Hospital, Coimbatore, India., Sarangapani S; Vision Research Foundation, Chennai, India., Kanavi MR; Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Beni AN; Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Yazdani S; Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Lashay A; Farabi Eye Hospital, Tehran University Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran., Naderifar H; Farabi Eye Hospital, Tehran University Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran., Khatibi N; Farabi Eye Hospital, Tehran University Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran., Fea A; Dipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy., Lavia C; Dipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy., Dallorto L; Dipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy., Rolle T; Dipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy., Frezzotti P; Ophthalmology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy., Paoli D; Department of Ophthalmology, Monfalcone Hospital, Gorizia, Italy., Salvi E; Department of Health Sciences, University of Milan, Milan, Italy., Manunta P; Department of Nephrology, University Vita-Salute San Raffaele, Milan, Italy., Mori Y; Miyata Eye Hospital, Miyazaki, Japan., Miyata K; Miyata Eye Hospital, Miyazaki, Japan., Higashide T; Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan., Chihara E; Sensho-kai Eye Institute, Kyoto, Japan., Ishiko S; Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University, Asahikawa, Japan., Yoshida A; Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan., Yanagi M; Department of Ophthalmology and Visual Sciences, Hiroshima University, Hiroshima, Japan., Kiuchi Y; Department of Ophthalmology and Visual Sciences, Hiroshima University, Hiroshima, Japan., Ohashi T; Ohashi Eye Center, Sapporo, Japan., Sakurai T; Tane Memorial Eye Hospital, Osaka, Japan., Sugimoto T; Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Chuman H; Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Aihara M; Department of Ophthalmology, University of Tokyo, Tokyo, Japan., Inatani M; Department of Ophthalmology, Faculty of Medical Science, University of Fukui, Fukui, Japan., Miyake M; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan., Gotoh N; Center for Genomic Medicine, INSERM U852, Kyoto University Graduate School of Medicine, Kyoto, Japan., Matsuda F; Center for Genomic Medicine, INSERM U852, Kyoto University Graduate School of Medicine, Kyoto, Japan., Yoshimura N; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan., Ikeda Y; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Ueno M; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Sotozono C; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Jeoung JW; Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Sagong M; Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Republic of Korea., Park KH; Department of Ophthalmology, Seoul National University Bundang Hospital, Gyeonggi, Republic of Korea., Ahn J; Department of Ophthalmology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea., Cruz-Aguilar M; Genetics Department, Institute of Ophthalmology 'Conde de Valenciana', Mexico City, Mexico., Ezzouhairi SM; Clinique Spécialisée en Ophtalmologie Mohammedia, Mohammedia, Morocco., Rafei A; Laboratoires RAFEI, Mohammedia, Morocco., Chong YF; Singapore Eye Research Institute, Singapore., Ng XY; Singapore Eye Research Institute, Singapore., Goh SR; Singapore Eye Research Institute, Singapore., Chen Y; Singapore Eye Research Institute, Singapore., Yong VHK; Singapore Eye Research Institute, Singapore., Khan MI; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands., Olawoye OO; Department of Ophthalmology, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Department of Ophthalmology, University College Hospital, Ibadan, Nigeria., Ashaye AO; Department of Ophthalmology, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Department of Ophthalmology, University College Hospital, Ibadan, Nigeria., Ugbede I; ECWA Eye Hospital, Kano, Nigeria., Onakoya A; Department of Ophthalmology, University of Lagos, Lagos, Nigeria.; Guinness Eye Centre, Lagos University Teaching Hospital, Lagos, Nigeria., Kizor-Akaraiwe N; Department of Ophthalmology, ESUT Teaching Hospital Parklane, Enugu, Nigeria.; Eye Specialists Hospital, Enugu, Nigeria., Teekhasaenee C; Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Suwan Y; Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Supakontanasan W; Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Okeke S; Department of Ophthalmology, ESUT Teaching Hospital Parklane, Enugu, Nigeria.; Eye Specialists Hospital, Enugu, Nigeria., Uche NJ; Eye Specialists Hospital, Enugu, Nigeria.; Department of Ophthalmology, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.; Department of Ophthalmology, College of Medicine, University of Nigeria, Nsukka, Ituku Ozalla Campus, Enugu, Nigeria., Asimadu I; Department of Ophthalmology, ESUT Teaching Hospital Parklane, Enugu, Nigeria., Ayub H; Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan., Akhtar F; Pakistan Institute of Ophthalmology, Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan., Kosior-Jarecka E; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Lukasik U; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Lischinsky I; Centro Oftalmologico Lischinsky, Tucumán, Argentina., Castro V; Universidad Peruana Cayetano Heredia, Hospital Nacional Arzobispo Loayza, Lima, Peru., Grossmann RP; Instituto de Glaucoma y Catarata, Lima, Peru., Sunaric Megevand G; Clinical Research Centre Adolphe de Rothschild, Société Médicale de Beaulieu, Geneva, Switzerland., Roy S; Clinical Research Centre Adolphe de Rothschild, Société Médicale de Beaulieu, Geneva, Switzerland., Dervan E; Mater Misericordiae University Hospital, Dublin, Ireland., Silke E; Mater Misericordiae University Hospital, Dublin, Ireland., Rao A; Shri Mithu Tulsi, LV Prasad Eye Institute, Bhubaneswar, India., Sahay P; Shri Mithu Tulsi, LV Prasad Eye Institute, Bhubaneswar, India., Fornero P; Hospital Córdoba, Córdoba, Argentina., Cuello O; Hospital Córdoba, Córdoba, Argentina., Sivori D; Fundación para el Estudio del Glaucoma, Buenos Aires, Argentina., Zompa T; Centro Oftalmologico Charles, Buenos Aires, Argentina., Mills RA; Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia., Souzeau E; Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia., Mitchell P; Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia., Wang JJ; Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia., Hewitt AW; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia., Coote M; Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia., Crowston JG; Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia., Astakhov SY; Department of Ophthalmology, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia., Akopov EL; Department of Ophthalmology, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia., Emelyanov A; Department of Ophthalmology, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia.; St. Petersburg Academic University, St. Petersburg, Russia., Vysochinskaya V; St. Petersburg Academic University, St. Petersburg, Russia., Kazakbaeva G; Ufa Eye Research Institute, Ufa, Russia., Fayzrakhmanov R; Ufa Eye Research Institute, Ufa, Russia., Al-Obeidan SA; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Owaidhah O; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia., Aljasim LA; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia., Chowbay B; Clinical Pharmacology, SingHealth, Singapore.; Clinical Pharmacology Laboratory, National Cancer Centre, Singapore.; Office of Clinical Sciences, Duke-NUS Medical School, Singapore., Foo JN; Genome Institute of Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore., Soh RQ; Genome Institute of Singapore, Singapore., Sim KS; Genome Institute of Singapore, Singapore., Xie Z; Genome Institute of Singapore, Singapore., Cheong AWO; Genome Institute of Singapore, Singapore., Mok SQ; Genome Institute of Singapore, Singapore., Soo HM; Genome Institute of Singapore, Singapore., Chen XY; Genome Institute of Singapore, Singapore., Peh SQ; Genome Institute of Singapore, Singapore., Heng KK; Genome Institute of Singapore, Singapore., Husain R; Singapore National Eye Center, Singapore., Ho SL; Department of Ophthalmology, Tan Tock Seng Hospital, Singapore., Hillmer AM; Genome Institute of Singapore, Singapore., Cheng CY; Singapore Eye Research Institute, Singapore.; Singapore National Eye Center, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Academic Clinical Program for Ophthalmology and Visual Sciences, Office of Clinical and Academic Faculty Affairs, Duke-NUS Graduate Medical School, Singapore., Escudero-Domínguez FA; Department of Ophthalmology, University Hospital of Salamanca, Salamanca, Spain., González-Sarmiento R; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.; Molecular Medicine Unit, Department of Medicine, University of Salamanca, Salamanca, Spain., Martinon-Torres F; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain.; GENVIP Research Group, Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, Spain., Salas A; Unidade de Xenética, Departamento de Anatomía Patolóxica e Ciencias Forenses, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Pathanapitoon K; Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Hansapinyo L; Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Wanichwecharugruang B; Department of Ophthalmology, Rajavithi Hospital, Bangkok, Thailand., Kitnarong N; Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand., Sakuntabhai A; Institut Pasteur, Functional Genetics of Infectious Diseases Unit, Department of Genomes and Genetics, Paris, France.; Centre National de la Recherche Scientifique, Unité de Recherche Associée 3012, Paris, France., Nguyn HX; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Nguyn GTT; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Nguyn TV; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Zenz W; Department of General Pediatrics, Medical University of Graz, Graz, Austria., Binder A; Department of General Pediatrics, Medical University of Graz, Graz, Austria., Klobassa DS; Department of General Pediatrics, Medical University of Graz, Graz, Austria., Hibberd ML; Genome Institute of Singapore, Singapore.; Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, UK., Davila S; Genome Institute of Singapore, Singapore., Herms S; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Division of Medical Genetics, University Hospital Basel, Basel, Switzerland., Nöthen MM; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.; Institute of Human Genetics, University of Bonn, Bonn, Germany., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Rautenbach RM; Division of Ophthalmology, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa., Ziskind A; Division of Ophthalmology, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa., Carmichael TR; Division of Ophthalmology, University of the Witwatersrand, Johannesburg, South Africa., Ramsay M; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Álvarez L; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., García M; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., González-Iglesias H; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., Rodríguez-Calvo PP; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., Fernández-Vega Cueto L; Fernández-Vega University Institute and Foundation of Ophthalmological Research, University of Oviedo, Oviedo, Spain.; Fernández-Vega Ophthalmological Institute, Oviedo, Spain., Oguz Ç; Department of Genetics, Eskisehir Osmangazi University, Meselik, Eskisehir, Turkey., Tamcelik N; Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey., Atalay E; Singapore Eye Research Institute, Singapore.; Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey., Batu B; Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey., Aktas D; DAMAGEN Genetic Diagnostic Center, Ankara, Turkey., Kasım B; Department of Ophthalmology, Hacettepe University, Faculty of Medicine, Ankara, Turkey., Wilson MR; School of Medicine, Wayne State University, Detroit, Michigan, USA., Coleman AL; Center for Community Outreach and Policy, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA., Liu Y; Department of Cellular Biology and Anatomy, Center for Biotechnology and Genomic Medicine, James and Jean Culver Discovery Institute, Augusta University, Augusta, Georgia, USA., Challa P; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA., Herndon L; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA., Kuchtey RW; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Kuchtey J; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Curtin K; John A. 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Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Zangwill LM; Hamilton Glaucoma Center, Department of Ophthalmology and Shiley Eye Institute, University of California, San Diego, San Diego, California, USA., Wong TY; Singapore Eye Research Institute, Singapore.; Singapore National Eye Center, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Nakano M; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kinoshita S; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.; Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., den Hollander AI; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands.; Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands., Vesti E; Department of Ophthalmology, University of Turku and Turku University Hospital, Turku, Finland., Fingert JH; Institute for Vision Research, University of Iowa, Iowa City, Iowa, USA.; Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Lee RK; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA., Sit AJ; Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA., Shingleton BJ; Ophthalmic Consultants of Boston, Boston, Massachusetts, USA., Wang N; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Cusi D; Institute of Biomedical Technologies, Italian National Research Centre (ITB-CNR), Segrate-Milano, Italy., Qamar R; Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.; Department of Biochemistry, Al-Nafees Medical College and Hospital, Isra University, Islamabad, Pakistan., Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Raychaudhuri S; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Institute of Inflammation and Repair, University of Manchester, Manchester, UK.; Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden., Heegaard S; Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Department of Pathology, Rigshospitalet, Eye Pathology Section, University of Copenhagen, Copenhagen, Denmark., Kivelä T; Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Reis A; David Tvildiani Medical University, Tbilisi, Georgia., Kruse FE; Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Weinreb RN; Hamilton Glaucoma Center, Department of Ophthalmology and Shiley Eye Institute, University of California, San Diego, San Diego, California, USA., Pasquale LR; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA., Haines JL; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.; Institute of Computational Biology, Case Western Reserve University, Cleveland, Ohio, USA., Thorsteinsdottir U; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Jonasson F; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Ophthalmology, Landspitali University Hospital, Reykjavik, Iceland., Allingham RR; Singapore Eye Research Institute, Singapore.; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA., Milea D; Singapore Eye Research Institute, Singapore.; Singapore National Eye Center, Singapore.; Academic Clinical Program for Ophthalmology and Visual Sciences, Office of Clinical and Academic Faculty Affairs, Duke-NUS Graduate Medical School, Singapore., Ritch R; Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA., Kubota T; Department of Ophthalmology, Oita University Faculty of Medicine, Oita, Japan., Tashiro K; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Vithana EN; Singapore Eye Research Institute, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Micheal S; Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands., Topouzis F; Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Craig JE; Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia., Dubina M; Department of Ophthalmology, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia.; St. Petersburg Academic University, St. Petersburg, Russia., Sundaresan P; Dr. G.Venkataswamy Eye Research Institute, Aravind Medical Research Foundation, Aravind Eye Hospital, Madurai, India., Stefansson K; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Wiggs JL; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA., Pasutto F; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Khor CC; Singapore Eye Research Institute, Singapore.; Genome Institute of Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Publikováno v: Nature genetics [Nat Genet] 2017 Jul; Vol. 49 (7), pp. 993-1004. Date of Electronic Publication: 2017 May 29.

A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.

Autor: Aung T; 1] Singapore Eye Research Institute, Singapore. [2] Singapore National Eye Center, Singapore. [3] Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. [4] Division of Human Genetics, Genome Institute of Singapore, Singapore. [5] Duke University-National University of Singapore Graduate Medical School, Singapore., Ozaki M; 1] Ozaki Eye Hospital, Hyuga, Japan. [2] Hayashi Eye Hospital, Fukuoka, Japan., Mizoguchi T; Mizoguchi Eye Hospital, Sasebo, Japan., Allingham RR; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA., Li Z; Division of Human Genetics, Genome Institute of Singapore, Singapore., Haripriya A; Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India., Nakano S; Department of Ophthalmology, Oita University Faculty of Medicine, Oita, Japan., Uebe S; Institute of Human Genetics, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany., Harder JM; Howard Hughes Medical Institute, Jackson Laboratory, Bar Harbor, Maine, USA., Chan AS; 1] Singapore Eye Research Institute, Singapore. [2] Singapore National Eye Center, Singapore., Lee MC; Singapore Eye Research Institute, Singapore., Burdon KP; 1] Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia. [2] Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Astakhov YS; Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia., Abu-Amero KK; 1] Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. [2] Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, Florida, USA., Zenteno JC; 1] Department of Genetics, Institute of Ophthalmology Conde de Valenciana, Mexico City, Mexico. [2] Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico., Nilgün Y; Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Turkey., Zarnowski T; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Pakravan M; Department of Ophthalmology, Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Safieh LA; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia., Jia L; Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wang YX; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China., Williams S; Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa., Paoli D; Department of Ophthalmology, Monfalcone Hospital, Gorizia, Italy., Schlottmann PG; Organización Médica de Investigación, Buenos Aires, Argentina., Huang L; 1] Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China. [2] School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. [3] Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China., Sim KS; Division of Human Genetics, Genome Institute of Singapore, Singapore., Foo JN; Division of Human Genetics, Genome Institute of Singapore, Singapore., Nakano M; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Ikeda Y; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kumar RS; Glaucoma Services, Narayana Nethralaya Eye Hospital, Bangalore, India., Ueno M; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Manabe S; Hayashi Eye Hospital, Fukuoka, Japan., Hayashi K; Hayashi Eye Hospital, Fukuoka, Japan., Kazama S; Shinjo Eye Clinic, Miyazaki, Japan., Ideta R; Ideta Eye Hospital, Kumamoto, Japan., Mori Y; Miyata Eye Hospital, Miyazaki, Japan., Miyata K; 1] Miyata Eye Hospital, Miyazaki, Japan. [2] Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Sugiyama K; Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan., Higashide T; Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan., Chihara E; Sensho-kai Eye Institute, Kyoto, Japan., Inoue K; Inouye Eye Hospital, Tokyo, Japan., Ishiko S; Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University, Asahikawa, Japan., Yoshida A; Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan., Yanagi M; Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan., Kiuchi Y; Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan., Aihara M; Yotsuya Shirato Eye Clinic, Tokyo, Japan., Ohashi T; Ohashi Eye Center, Sapporo, Japan., Sakurai T; Tane Memorial Eye Hospital, Osaka, Japan., Sugimoto T; Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Chuman H; Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Matsuda F; Center for Genomic Medicine/INSERM U852, Kyoto University Graduate School of Medicine, Kyoto, Japan., Yamashiro K; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan., Gotoh N; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan., Miyake M; 1] Center for Genomic Medicine/INSERM U852, Kyoto University Graduate School of Medicine, Kyoto, Japan. [2] Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan., Astakhov SY; Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia., Osman EA; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Al-Obeidan SA; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Owaidhah O; Department of Ophthalmology, Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Al-Jasim L; Department of Ophthalmology, Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Al Shahwan S; Department of Ophthalmology, Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Fogarty RA; Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia., Leo P; University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia., Yetkin Y; Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Turkey., Oğuz Ç; Department of Ophthalmology, Eskisehir Osmangazi University, Meselik, Turkey., Kanavi MR; Department of Ophthalmology, Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Beni AN; Department of Ophthalmology, Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Yazdani S; Department of Ophthalmology, Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Akopov EL; Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia., Toh KY; Division of Human Genetics, Genome Institute of Singapore, Singapore., Howell GR; Howard Hughes Medical Institute, Jackson Laboratory, Bar Harbor, Maine, USA., Orr AC; Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada., Goh Y; Division of Human Genetics, Genome Institute of Singapore, Singapore., Meah WY; Division of Human Genetics, Genome Institute of Singapore, Singapore., Peh SQ; Division of Human Genetics, Genome Institute of Singapore, Singapore., Kosior-Jarecka E; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Lukasik U; Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland., Krumbiegel M; Institute of Human Genetics, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany., Vithana EN; Singapore Eye Research Institute, Singapore., Wong TY; 1] Singapore Eye Research Institute, Singapore. [2] Singapore National Eye Center, Singapore. [3] Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Liu Y; 1] Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA. [2] Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, Georgia, USA., Koch AE; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Challa P; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA., Rautenbach RM; Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa., Mackey DA; Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia., Hewitt AW; 1] Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. [2] Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia., Mitchell P; Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia., Wang JJ; Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia., Ziskind A; Division of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa., Carmichael T; Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa., Ramakrishnan R; Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India., Narendran K; Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India., Venkatesh R; Intraocular Lens and Cataract Clinic, Aravind Eye Hospital, Madurai, India., Vijayan S; Department of Genetics, Aravind Medical Research Foundation, Madurai, India., Zhao P; Department of Ophthalmology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, China., Chen X; Department of Ophthalmology, First Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang Uygur Autonomous Region, China., Guadarrama-Vallejo D; 1] Department of Genetics, Institute of Ophthalmology Conde de Valenciana, Mexico City, Mexico. [2] Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico., Cheng CY; 1] Singapore Eye Research Institute, Singapore. [2] Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Perera SA; 1] Singapore Eye Research Institute, Singapore. [2] Singapore National Eye Center, Singapore., Husain R; 1] Singapore Eye Research Institute, Singapore. [2] Singapore National Eye Center, Singapore., Ho SL; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore., Welge-Luessen UC; Department of Ophthalmology, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany., Mardin C; Department of Ophthalmology, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany., Schloetzer-Schrehardt U; Department of Ophthalmology, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany., Hillmer AM; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore., Herms S; 1] Institute of Human Genetics, University of Bonn, Bonn, Germany. [2] Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany. [3] Division of Medical Genetics, University Hospital, Basel, Switzerland. [4] Human Genetics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Nöthen MM; 1] Institute of Human Genetics, University of Bonn, Bonn, Germany. [2] Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany., Weisschuh N; Institute for Ophthalmic Research, Department of Ophthalmology, Tübingen, Germany., Shetty R; Glaucoma Services, Narayana Nethralaya Eye Hospital, Bangalore, India., Ghosh A; 1] Singapore Eye Research Institute, Singapore. [2] Genes, Repair and Regeneration in Ophthalmic Workstation Research Laboratory, Narayana Nethralaya Foundation, Bangalore, India., Teo YY; 1] Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA. [2] Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Brown MA; University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia., Lischinsky I; Centro Oftalmológico Lischinsky, Tucumán, Argentina., Crowston JG; 1] Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia. [2] Department of Ophthalmology, University of Melbourne, Melbourne, Victoria, Australia., Coote M; 1] Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia. [2] Department of Ophthalmology, University of Melbourne, Melbourne, Victoria, Australia., Zhao B; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia., Sang J; Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Zhang N; Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China., You Q; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China., Vysochinskaya V; St. Petersburg Academic University, St. Petersburg, Russia., Founti P; Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, American Hellenic Educational Progressive Association Hospital, Thessaloniki, Greece., Chatzikyriakidou A; Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Lambropoulos A; Department of Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Anastasopoulos E; Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, American Hellenic Educational Progressive Association Hospital, Thessaloniki, Greece., Coleman AL; Center for Community Outreach and Policy, Stein Eye Institute, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA., Wilson MR; Wayne State University, Detroit, Michigan, USA., Rhee DJ; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA., Kang JH; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., May-Bolchakova I; Department of Ophthalmology, Military Hospital Begin, Paris, France., Heegaard S; 1] Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark. [2] Department of Ophthalmology, Glostrup University Hospital, Glostrup, Denmark., Mori K; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Alward WL; 1] Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, Iowa, USA. [2] Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Jonas JB; Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht Karls University Heidelberg, Heidelberg, Germany., Xu L; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China., Liebmann JM; New York University School of Medicine, Manhattan Eye, Ear and Throat Hospital, New York, New York, USA., Chowbay B; Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre of Singapore, Singapore., Schaeffeler E; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany., Schwab M; 1] Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany. [2] Department of Clinical Pharmacology, University Hospital, Tübingen, Germany. [3] German Cancer Consortium (DKTK), German Cancer Research Center, Heidelberg, Germany., Lerner F; Fundación para el Estudio del Glaucoma, Buenos Aires, Argentina., Wang N; Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Yang Z; 1] Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China. [2] School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. [3] Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China., Frezzotti P; Department of Surgery, Section of Ophthalmology, University of Siena, Siena, Italy., Kinoshita S; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Fingert JH; 1] Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, Iowa, USA. [2] Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Inatani M; Department of Ophthalmology, Faculty of Medical Science, University of Fukui, Fukui, Japan., Tashiro K; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Reis A; Institute of Human Genetics, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany., Edward DP; 1] King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. [2] Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Pasquale LR; 1] Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Kubota T; Department of Ophthalmology, Oita University Faculty of Medicine, Oita, Japan., Wiggs JL; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA., Pasutto F; Institute of Human Genetics, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany., Topouzis F; Department of Ophthalmology, Faculty of Medicine, Aristotle University of Thessaloniki, American Hellenic Educational Progressive Association Hospital, Thessaloniki, Greece., Dubina M; 1] Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia. [2] St. Petersburg Academic University, St. Petersburg, Russia., Craig JE; Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia., Yoshimura N; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan., Sundaresan P; Department of Genetics, Aravind Medical Research Foundation, Madurai, India., John SW; Howard Hughes Medical Institute, Jackson Laboratory, Bar Harbor, Maine, USA., Ritch R; Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA., Hauser MA; 1] Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA. [2] Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Khor CC; 1] Singapore Eye Research Institute, Singapore. [2] Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. [3] Division of Human Genetics, Genome Institute of Singapore, Singapore.

Publikováno v: Nature genetics [Nat Genet] 2015 Apr; Vol. 47 (4), pp. 387-92. Date of Electronic Publication: 2015 Feb 23.

Large-scale functional organization of long-range chromatin interaction networks.

Autor: Sandhu KS; Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672. sandhuks@iisermohali.ac.in, Li G, Poh HM, Quek YL, Sia YY, Peh SQ, Mulawadi FH, Lim J, Sikic M, Menghi F, Thalamuthu A, Sung WK, Ruan X, Fullwood MJ, Liu E, Csermely P, Ruan Y

Publikováno v: Cell reports [Cell Rep] 2012 Nov 29; Vol. 2 (5), pp. 1207-19. Date of Electronic Publication: 2012 Oct 25.

Chromatin Interaction Analysis with Paired-End Tag Sequencing (ChIA-PET) for mapping chromatin interactions and understanding transcription regulation.

Autor: Goh Y; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Fullwood MJ, Poh HM, Peh SQ, Ong CT, Zhang J, Ruan X, Ruan Y

Publikováno v: Journal of visualized experiments : JoVE [J Vis Exp] 2012 Apr 30 (62). Date of Electronic Publication: 2012 Apr 30.