Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Pegine B. Walrad"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
A large number of eukaryotic proteins are processed by single or combinatorial post-translational covalent modifications that may alter their activity, interactions and fate. The set of modifications of each protein may be considered a “regulatory
Externí odkaz:
https://doaj.org/article/d1c7e9d7814f425eb95a8ecb670e8cd1
Autor:
Rachel C Findlay, Mohamed Osman, Kirstin A Spence, Paul M Kaye, Pegine B Walrad, Laurence G Wilson
Publikováno v:
eLife, Vol 10 (2021)
Cellular motility is an ancient eukaryotic trait, ubiquitous across phyla with roles in predator avoidance, resource access, and competition. Flagellar motility is seen in various parasitic protozoans, and morphological changes in flagella during the
Externí odkaz:
https://doaj.org/article/228f928220244c1e99f120c6214cb864
Autor:
Tony Isebe, Suellen Rodrigues Maran, Pegine B. Walrad, Igor Cestari, Nilmar Silvio Moretti, Krista Fleck, Elton J R Vasconcelos, Victoria Jeffers, Natália Melquie Monteiro-Teles
Publikováno v:
Trends Parasitol
Protein lysine acetylation has emerged as a major regulatory post-translational modification in different organisms, present not only on histone proteins affecting chromatin structure and gene expression but also on nonhistone proteins involved in se
Autor:
Vijani Somaratne, Mitali Chatterjee, Marcela Montes de Oca, Pegine B. Walrad, Dimitris Lagos, Nidhi S. Dey, Renu Wickremasinghe, Srija Moulik, Bimalka Seneviratne, Hiro Goto, Sujai Senarathna, Paul M. Kaye, Shalindra Ranasinghe, Nayani Madarasinghe, Luiza Campos Reis, Sarah Forrester
Publikováno v:
The Journal of Clinical Investigation
Cutaneous leishmaniasis (CL) is a chronic skin disease caused by Leishmania parasites and in Sri Lanka, CL is caused by L. donovani. Pentavalent antimonials (e.g. sodium stibogluconate; SSG) are first line drugs for CL, despite protracted and painful
Autor:
Laurence G. Wilson, Kirstin A Spence, Rachel C Findlay, Pegine B. Walrad, Mohamed Osman, Paul M. Kaye
Publikováno v:
eLife, Vol 10 (2021)
Cellular motility is an ancient eukaryotic trait, ubiquitous across phyla with roles in predator avoidance, resource access, and competition. Flagellar motility is seen in various parasitic protozoans, and morphological changes in flagella during the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aba31ac9e39f4e888248992f462d1ad
https://eprints.whiterose.ac.uk/175718/1/elife_65051_v1.pdf
https://eprints.whiterose.ac.uk/175718/1/elife_65051_v1.pdf
Publikováno v:
Parasitology
Trypanothione is the primary thiol redox carrier in Trypanosomatids whose biosynthesis and utilization pathways contain unique enzymes that include suitable drug targets against the human parasites in this family. Overexpression of the rate-limiting
Autor:
Rafael Ricci-Azevedo, Mariana M. Chaves, Dario S. Zamboni, Rubens Daniel Miserani Magalhães, Tiago R. Ferreira, Pegine B. Walrad, Renan V. H. de Carvalho, David L. Sacks, Slavica Vaselek, Angela K. Cruz, Juliana Alcoforado Diniz, Lucas B. Lorenzon, Petr Volf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009230 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases
Leishmania major is the main causative agent of cutaneous leishmaniasis in the Old World. In Leishmania parasites, the lack of transcriptional control is mostly compensated by post-transcriptional mechanisms. Methylation of arginine is a conserved po
Autor:
Rachel Neish, Juliana B.T. Carnielli, Pegine B. Walrad, Eliza V. C. Alves-Ferreira, Katherine Newling, Charlotte S. Hughes, Barbora Vojtkova, Vincent Geohegan, Petr Volf, Carolina M. C. Catta-Preta, Jeremy C. Mottram, Andrei Mihut, Ben Powell, Laurence G. Wilson, Nicola Baker, Jovana Sadlova, Jon W. Pitchford, Jayanthi Anand
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Differentiation between distinct stages is fundamental for the life cycle of intracellular protozoan parasites and for transmission between hosts, requiring stringent spatial and temporal regulation. Here, we apply kinome-wide gene deletion and gene
Autor:
Rachel C, Findlay, Mohamed, Osman, Kirstin A, Spence, Paul M, Kaye, Pegine B, Walrad, Laurence G, Wilson
Publikováno v:
eLife
Cellular motility is an ancient eukaryotic trait, ubiquitous across phyla with roles in predator avoidance, resource access, and competition. Flagellar motility is seen in various parasitic protozoans, and morphological changes in flagella during the