Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

Autor: Caleb R Glassman, Leon Su, Sonia S Majri-Morrison, Hauke Winkelmann, Fei Mo, Peng Li, Magdiel Pérez-Cruz, Peggy P Ho, Ievgen Koliesnik, Nadine Nagy, Tereza Hnizdilova, Lora K Picton, Marek Kovar, Paul Bollyky, Lawrence Steinman, Everett Meyer, Jacob Piehler, Warren J Leonard, K Christopher Garcia

Publikováno v: eLife, Vol 10 (2021)

Interleukin-2 is a pleiotropic cytokine that mediates both pro- and anti-inflammatory functions. Immune cells naturally differ in their sensitivity to IL-2 due to cell type and activation state-dependent expression of receptors and signaling pathway

Externí odkaz: https://doaj.org/article/57746b1870ed4f558e975b56d281ba02

Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination

Autor: Rittika Chunder, Alicia Weier, Hannah Mäurer, Nicolas Luber, Michael Enders, Gabriele Luber, Thorsten Heider, Alfred Spitzer, Sabine Tacke, Janine Becker-Gotot, Christian Kurts, Radhika Iyer, Peggy P. Ho, William H. Robinson, Tobias V. Lanz, Stefanie Kuerten

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(10)

Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease of the central nervous system (CNS) with a high socioeconomic relevance. The pathophysiology of MS, which is both complex and incompletely understood, is believed to be influenced b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb572e5f27d93aa14f5fea77c401f965
https://pubmed.ncbi.nlm.nih.gov/35235454

Author response: Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

Autor: Nadine Nagy, Leon Su, Peggy P. Ho, Sonia S Majri-Morrison, Warren J. Leonard, Paul L. Bollyky, Jacob Piehler, Tereza Hnizdilova, Hauke Winkelmann, Caleb R. Glassman, Fei Mo, Ievgen O. Koliesnik, Peng Li, Everett Meyer, Magdiel Pérez-Cruz, K. Christopher Garcia, Lawrence Steinman, Marek Kovar, Lora Picton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7acb551959866336f5f5d1f487a3ef65
https://doi.org/10.7554/elife.65777.sa2

Reduced development of COVID-19 in children reveals molecular checkpoints gating pathogenesis illuminating potential therapeutics

Autor: Fok Moon Lum, Peggy P. Ho, Lawrence Steinman, Naftali Kaminski, Jonathan Baruch Steinman

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences

The reduced development of COVID-19 for children compared to adults provides some tantalizing clues on the pathogenesis and transmissibility of this pandemic virus. First, ACE2, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4bd43adbb809cfa0388921930ac9e12
https://pubmed.ncbi.nlm.nih.gov/32883878

Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4

Autor: Andrés Cruz-Herranz, Michael J. Levy, Peggy P. Ho, Patricia A. Nelson, Marc H. Levin, Raymond A. Sobel, Mark S. Anderson, Lawrence Steinman, Jeffrey Bennett, Collin M. Spencer, Alan S. Verkman, Corey N. Miller, Ryan C. Winger, Scott S. Zamvil, Ari J. Green, Sarah Hagberg, Sharon A. Sagan

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 51
Journal of nature and science, vol 3, iss 5

Aquaporin-4 (AQP4)-specific T cells are expanded in neuromyelitis optica (NMO) patients and exhibit Th17 polarization. However, their pathogenic role in CNS autoimmune inflammatory disease is unclear. Although multiple AQP4 T-cell epitopes have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c44b4bc005a99861cf4c3758f6a95c0
https://doi.org/10.1073/pnas.1617859114