Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Peggy Nakagawa"'
Autor:
Daniel R. Salomon, Thomas J. Kunicki, Paul Harrison, Shirley A. Williams, Steven R. Head, Diane J. Nugent, Peggy Nakagawa, Tony S. Mondala, P. Crisler
Publikováno v:
Journal of Thrombosis and Haemostasis. 7:2116-2122
Summary. Background: The Platelet Function Analyzer-100 (PFA-100) is widely used to measure platelet reactivity in whole blood under high shear. Objective: To characterize the genetic component of platelet reactivity among normal individuals, using t
Autor:
Diane J. Nugent, Peggy Nakagawa, Karyn E Yonekawa, Rachelle C. Blain, Guy Young, Amy E. Lovejoy
Publikováno v:
Blood Coagulation & Fibrinolysis. 18:547-553
Bleeding is the major adverse reaction to anticoagulants, leading to significant morbidity and even mortality. Protamine is a specific antidote for heparin yet is only partially effective for enoxaparin, and the activated factor X inhibitor fondapari
Autor:
Amy E. Lovejoy, Karyn E Yonekawa, Guy Young, Peggy Nakagawa, Rachelle C. Blain, Diane J. Nugent
Publikováno v:
Blood Coagulation & Fibrinolysis. 18:97-103
New anticoagulants, including the direct thrombin inhibitors (DTIs) and fondaparinux, are increasingly replacing unfractionated heparin and enoxaparin. We examined the effects of argatroban (n = 60), bivalirudin (n = 44), heparin (n = 14), enoxaparin
Publikováno v:
Haemophilia. 12:598-604
Summary. The treatment of bleeding for haemophilic patients with inhibitors relies on the use of the bypassing agents, recombinant factor VIIa and factor eight inhibitor bypass activity (FEIBA). While both therapies are effective in the majority of b
Autor:
Peggy Nakagawa, Michael Schwartz, Mei Chang, Diane J. Nugent, Shirley A. Williams, Karen L. Imfeld, Jeffrey S. Buzby
Publikováno v:
Blood. 102:887-895
To determine if megakaryocytes are targeted by immune thrombocytopenic purpura (ITP) autoantibodies, as are platelets, we have studied the effects of ITP plasma on in vitro megakaryocytopoiesis. Umbilical cord blood mononuclear cells were incubated i
Publikováno v:
Perfusion. 19(5)
We investigated the anticoagulant effects of argatroban, a direct thrombin inhibitor, versus heparin in extracorporeal membrane oxygenation (ECMO) circuits. Three sham circuits were prepared according to our hospital’s standard practice and run for
Autor:
Paul D. Gershon, Peggy Nakagawa, Daniel Diaz, Geetha Puthenveetil, Diane J. Nugent, Nick Park
Publikováno v:
Blood. 120:2119-2119
Abstract 2119 Background: Hydroxyurea (HU) is clinically effective in reducing the frequency of pain crises in adults and children with sickle cell disease (SCD). In addition to increased fetal hemoglobin production, HU is known to induce macrocytosi
Publikováno v:
Blood. 116:1446-1446
Abstract 1446 Currently, there is no single assay that will detect platelet function abnormalities in all individuals. We prospectively studied 369 patients with a strong history of bruising and mucosal membrane bleeding for possible platelet dysfunc
Publikováno v:
Blood. 114:4201-4201
Abstract 4201 Introduction Factor XIII deficient patients may present at any age, with a variety of bleeding symptoms, poor wound healing, and in females, frequent miscarriages. Factor XIII (FXIII) is a transglutaminase enzyme that was first discover
Autor:
Karen L. Imfeld, Shirley A. Williams, Thomas J. Kunicki, Diane J. Nugent, Peggy Nakagawa, Lei-Qian Tai
Publikováno v:
Blood. 110:569-569
Pediatric idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder characterized by immune-mediated platelet destruction. Current evidence suggests that childhood ITP is associated with an imbalance within the T cell regulatory network follow