Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Peggy Liu-Kreyche"'
Autor:
Peggy Liu-Kreyche, Hong Shen, Anthony M. Marino, Ramaswamy A. Iyer, W. Griffith Humphreys, Yurong Lai
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Antibody-drug conjugates (ADCs) are composed of an antibody linked to cytotoxic anticancer payloads. ADCs recognize tumor-specific cell surface antigens and are internalized into lysosomes where proteolytic enzymes release the cytotoxic payloads. Eff
Externí odkaz:
https://doaj.org/article/8853340c5ce94343965668f1a455302c
Autor:
Li Zhu, Alban Allentoff, Christine Huang, Long Yuan, Kimberly Voronin, Renuka Pillutla, Peggy Liu-Kreyche, Naiyu Zheng, R. Marcus Fancher, Ramaswamy A. Iyer, Qin C Ji
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 165:198-206
Stable isotope labeled (SIL) compounds have been commonly used as internal standards (IS) to ensure the accuracy and quality of liquid chromatography–mass spectrometry (LC–MS) bioanalytical assays. Recently, the application of SIL drugs and LC–
Autor:
Yurong Lai, W. Griffith Humphreys, Anthony M. Marino, Ramaswamy A. Iyer, Hong Shen, Peggy Liu-Kreyche
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology
Frontiers in Pharmacology
Antibody-drug conjugates (ADCs) are composed of an antibody linked to cytotoxic anticancer payloads. ADCs recognize tumor-specific cell surface antigens and are internalized into lysosomes where proteolytic enzymes release the cytotoxic payloads. Eff
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S59
Publikováno v:
Cancer Chemotherapy and Pharmacology. 69:51-56
To assess the inhibition and induction potential of tanespimycin and its major metabolite, 17-amino-17-demethoxygeldanamycin (17-AG) on cytochrome P450 (CYP) enzymes. The inhibitory effect of tanespimycin and 17-AG on various CYP enzymes was determin
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 40(6)
The absorption, distribution, metabolism, and excretion (ADME) and the pharmacokinetic characteristics of BMS-562086 [pexacerfont; 8-(6-methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo(1,5-a)-1,3,5-triazin-4-amine (DPC-A6944
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 41(4)
We determined the metabolism of [2-(14)C]p-hydroxyphenyl acetic acid (p-HPA) in rat (male, Sprague-Dawley), monkey (male, Cynomolgus), and human (male, Caucasian) hepatocytes, and in bile-duct cannulated (BDC) rats (male, Sprague-Dawley). Unchanged p
Autor:
Lian Zhou, Vikram Roongta, Bethanne M. Warrack, Scott B. Tran, Sanjeev Kaul, Ramaswamy A. Iyer, Robert R. Espina, Peggy Liu-Kreyche
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 38(4)
The disposition of stavudine, a potent and orally active nucleoside reverse transcriptase inhibitor, was investigated in six healthy human subjects. Before dosing humans with [1'-(14)C]stavudine, a tissue distribution study was performed in Long-Evan