Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Peggy L. Micca"'
Autor:
W. David Sedwick, Shiela R. Campbell, William J. Suling, Roy L. Kisliuk, David W. Borhani, Robert C. Reynolds, William R. Waud, Ralph G. Fairchild, A.K.W. Leung, Richard W. Dixon, James M. Riordan, Sherry F. Queener, Peggy L. Micca
Publikováno v:
Journal of Medicinal Chemistry. 50:3283-3289
Two boron-containing, ortho-icosahedral carborane lipophilic antifolates were synthesized, and the crystal structures of their ternary complexes with human dihydrofolate reductase (DHFR) and dihydronicotinamide adenine dinucleotide phosphate were det
Autor:
Peggy L. Micca, Jeffrey A. Coderre, Albert J. van der Kogel, John W. Hopewell, G. M. Morris, Ilja Verhagen, B.J. Kleiboer
Publikováno v:
Radiation Research, 166, 3, pp. 495-503
Radiation Research, 166, 495-503
Radiation Research, 166, 495-503
Item does not contain fulltext Selective irradiation of the vasculature of the rat spinal cord was used in this study, which was designed specifically to address the question as to whether it is the endothelial cell or the glial progenitor cell that
Publikováno v:
Applied Radiation and Isotopes. 61:917-921
The steroid dexamethasone sodium phosphate (DEX) is routinely used to treat edema in brain tumor patients. The objective of the present study was to evaluate the effects of DEX on the uptake of boronophenylalanine (BPA) using the rat 9L gliosarcoma t
Autor:
Ricardo N. Garavaglia, Michiko Miura, Maria E. Itoiz, Peggy L. Micca, Raúl Jiménez Rebagliati, Jeffrey A. Coderre, Erica L. Kreimann, Daniel A. Batistoni, Mariía J Roberti, Amanda E. Schwint, Elisa M. Heber
Publikováno v:
Archives of Oral Biology. 48:223-232
Boron Neutron Capture Therapy (BNCT) is a bimodal cancer treatment based on the selective accumulation of 10 B in tumors and concurrent irradiation with thermalized neutrons. The short-range, high-LET radiation produced by the capture of neutrons by
Autor:
Lynn Kuo, Crystal Xue, Henry M. Smilowitz, Nathanial Dyment, Daniel Sasso, Qian Wu, Peggy L. Micca
Publikováno v:
Cancer immunology, immunotherapy : CII. 65(2)
Previously, we developed a clinically relevant therapy model for advanced intracerebral B16 melanomas in syngeneic mice combining radiation and immunotherapies. Here, 7 days after B16-F10-luc2 melanoma cells were implanted intracerebrally (D7), synge
Autor:
Peggy L. Micca, Ruimei Ma, G. M. Morris, Diana T. Lombardo, Kelly M. Youngs, Daniel N. Slatkin, Duane A. Hoch, Michiko Miura, Jeffrey A. Coderre, John Kalef-Ezra
Publikováno v:
Radiation Research. 155:603-610
Miura, M., Morris, G. M., Micca, P. L., Lombardo, D. T., Youngs, K. M., Kalef-Ezra, J. A., Hoch, D. A., Slatkin, D. N., Ma, R. and Coderre, J. A. Boron Neutron Capture Therapy of a Murine Tumor using a Lipophilic Carboranyltetraphenylporphyrin. The f
Publikováno v:
Journal of Neuro-Oncology. 52:101-110
New clinical protocols are being developed that will entail the administration of considerably higher doses of the boron delivery agent boronophenylalanine (BPA) than those in current clinical use. Fractionation (2 or 4 fractions) of BPA mediated bor
Autor:
Duane A. Hoch, Peggy L. Micca, Darrel D. Joel, Michiko Miura, Jeffrey A. Coderre, Marta M. Nawrocky, Henry M. Smilowitz, Daniel N. Slatkin
Publikováno v:
Journal of Neuro-Oncology. 52:111-117
The biodistributions of carborane-containing copper porphyrins, CuTCP and CuTCPH, have been studied previously in mice bearing subcutaneously implanted mammary carcinomas. We now report biodistributions of those porphyrins in Fischer 344 rats bearing
Autor:
Gabor Vetek, Charles S. Landis, Lawrence L. Latour, Frank Telang, Peggy L. Micca, Jeffrey A. Coderre, William D. Rooney, Xin Li, Ildiko Palyka, Charles S. Springer
Publikováno v:
Magnetic Resonance in Medicine. 44:563-574
For bolus-tracking studies, it is commonly assumed that CR concentration bears a linear relationship with the measured (usually longitudinal) 1H2O relaxation rate constant, R*1 ≡(T1 *)–1. This requires that equilibrium transcytolemmal water excha
Autor:
W. Tu, Kelly M. Youngs, Daniel N. Slatkin, Marta M. Nawrocky, Darrel D. Joel, Peggy L. Micca, Henry M. Smilowitz, Jeffrey A. Coderre
Publikováno v:
Journal of Neuro-Oncology. 46:193-203
Glioblastoma multiforme (GBM) is the most common primary human brain tumor. About 7000 new cases are diagnosed yearly in the USA. Despite current neurosurgical and postoperative radiotherapeutic tumor cytoreduction methods, in most cases occult foci