Circular RNA repertoires are associated with evolutionarily young transposable elements

Autor: Franziska Gruhl, Peggy Janich, Henrik Kaessmann, David Gatfield

Publikováno v: eLife, Vol 10 (2021)

Circular RNAs (circRNAs) are found across eukaryotes and can function in post-transcriptional gene regulation. Their biogenesis through a circle-forming backsplicing reaction is facilitated by reverse-complementary repetitive sequences promoting pre-

Externí odkaz: https://doaj.org/article/ba7631f06e34482fa022301c15ee76d3

Analyzing the temporal regulation of translation efficiency in mouse liver

Autor: Peggy Janich, Alaaddin Bulak Arpat, Violeta Castelo-Szekely, David Gatfield

Publikováno v: Genomics Data, Vol 8, Iss C, Pp 41-44 (2016)

Mammalian physiology and behavior follow daily rhythms that are orchestrated by endogenous timekeepers known as circadian clocks. Rhythms in transcription are considered the main mechanism to engender rhythmic gene expression, but important roles for

Externí odkaz: https://doaj.org/article/22c4a3790e474047953746c4041e7ab2

Circular RNA repertoires are associated with evolutionarily young transposable elements

Autor: Henrik Kaessmann, Peggy Janich, Franziska Gruhl, David Gatfield

Circular RNAs (circRNAs) are found across eukaryotes and can function in post-transcriptional gene regulation. Their biogenesis through a circle-forming backsplicing reaction is facilitated by reverse-complementary repetitive sequences promoting pre-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7270eabbc44d982f091680120a6534b8
https://doi.org/10.1101/2021.03.01.433421

Transcriptome-wide sites of collided ribosomes reveal principles of translational pausing

Autor: Angélica Liechti, René Dreos, Mara De Matos, Peggy Janich, David Gatfield, Alaaddin Bulak Arpat

Translation initiation is the major regulatory step defining the rate of protein production from an mRNA. Meanwhile, the impact of non-uniform ribosomal elongation rates is largely unknown. Using a modified ribosome profiling protocol based on footpr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2ed8cf131e472b21f17b43ea5bdfa87
https://doi.org/10.1101/710061

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Autor: Sadaf Khan, Peggy Janich, Hong Jin, Felix Lasitschka, Owen J. Sansom, Athena Georgilis, Torsten Wuestefeld, Lars Zender, Gareth J. Inman, Ana Banito, Tae-Won Kang, Kelly J. Morris, Jesús Gil, Gopuraja Dharmalingam, Dimitris Athineos, Thomas Longerich, Juan Carlos Acosta, Ambrosius P. Snijders, Gloria Pascual, David Capper, Salvador Aznar Benitah, Catrin Pritchard, Thomas L. Carroll, Mindaugas Andrulis, Jennifer P. Morton

Publikováno v: Nature cell biology
U221
Acosta, J C, Banito, A, Wuestefeld, T, Georgilis, A, Janich, P, Morton, J P, Athineos, D, Kang, T-W, Lasitschka, F, Andrulis, M, Pascual, G, Morris, K J, Khan, S, Jin, H, Dharmalingam, G, Snijders, A P, Carroll, T, Capper, D, Pritchard, C, Inman, G J, Longerich, T, Sansom, O J, Benitah, S A, Zender, L & Gil, J 2013, ' A complex secretory program orchestrated by the inflammasome controls paracrine senescence ', Nature Cell Biology, vol. 15, no. 8, pp. 978-90 . https://doi.org/10.1038/ncb2784
Recercat. Dipósit de la Recerca de Catalunya
instname

Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells implement a complex pro-inflammatory response termed the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence, activates immune surveilla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ee10c145bf6bb6727764ccb962a204
http://europepmc.org/articles/PMC3732483