Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Peggy, Scherle"'
Autor:
Norman Fultang, Ashley M. Schwab, Sophia McAneny-Droz, Alexander Grego, Stephanie Rodgers, Brian Vidal Torres, Diane Heiser, Peggy Scherle, Neha Bhagwat
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
MCL1 is a member of the BCL2 family of apoptosis regulators, which play a critical role in promoting cancer survival and drug resistance. We previously described PRT1419, a potent, MCL1 inhibitor with anti-tumor efficacy in various solid and hematolo
Externí odkaz:
https://doaj.org/article/a51826064c8141df84713321fc7b43a7
Autor:
Zachary A. Hing, Janek S. Walker, Ethan C. Whipp, Lindsey Brinton, Matthew Cannon, Pu Zhang, Steven Sher, Casey B. Cempre, Fiona Brown, Porsha L. Smith, Claudio Agostinelli, Stefano A. Pileri, Jordan N. Skinner, Katie Williams, Hannah Phillips, Jami Shaffer, Larry P. Beaver, Alexander Pan, Kyle Shin, Charles T. Gregory, Gulcin H. Ozer, Selen A. Yilmaz, Bonnie K. Harrington, Amy M. Lehman, Lianbo Yu, Vincenzo Coppola, Pearlly Yan, Peggy Scherle, Min Wang, Philip Pitis, Chaoyi Xu, Kris Vaddi, Selina Chen-Kiang, Jennifer Woyach, James S. Blachly, Lapo Alinari, Yiping Yang, John C. Byrd, Robert A. Baiocchi, Bradley W. Blaser, Rosa Lapalombella
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Richter’s Transformation is a treatment-resistant and fatal progression from Chronic Lymphocytic Leukemia (CLL) to an aggressive lymphoma. Here, the authors show that PRMT5 is upregulated months prior to and after transformation, PRMT5 overexpressi
Externí odkaz:
https://doaj.org/article/69b4b26dffde485788921c4c7e1fc14a
Autor:
Cecile Geuijen, Paul Tacken, Liang-Chuan Wang, Rinse Klooster, Pieter Fokko van Loo, Jing Zhou, Arpita Mondal, Yao-bin Liu, Arjen Kramer, Thomas Condamine, Alla Volgina, Linda J. A. Hendriks, Hans van der Maaden, Eric Rovers, Steef Engels, Floris Fransen, Renate den Blanken-Smit, Vanessa Zondag-van der Zande, Abdul Basmeleh, Willem Bartelink, Ashwini Kulkarni, Wilfred Marissen, Cheng-Yen Huang, Leslie Hall, Shane Harvey, Soyeon Kim, Marina Martinez, Shaun O’Brien, Edmund Moon, Steven Albelda, Chrysi Kanellopoulou, Shaun Stewart, Horacio Nastri, Alexander B. H. Bakker, Peggy Scherle, Ton Logtenberg, Gregory Hollis, John de Kruif, Reid Huber, Patrick A. Mayes, Mark Throsby
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The anti-tumour effect of immune checkpoint inhibitors is potentiated by CD137 agonists in preclinical models, but translation of these results to the clinical practice is hampered by toxicity. Authors describe here a human CD137xPD-L1 bispecific ant
Externí odkaz:
https://doaj.org/article/4044cbbb9c1d4937ac08f857eba69b30
Autor:
Shelby L Sloan, Kyle A Renaldo, Mackenzie Long, Ji-Hyun Chung, Lindsay E Courtney, Konstantin Shilo, Youssef Youssef, Sarah Schlotter, Fiona Brown, Brett G Klamer, Xiaoli Zhang, Ayse S Yilmaz, Hatice G Ozer, Victor E Valli, Kris Vaddi, Peggy Scherle, Lapo Alinari, William C Kisseberth, Robert A Baiocchi
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250839 (2021)
Non-Hodgkin lymphoma (NHL) is a heterogeneous group of blood cancers arising in lymphoid tissues that commonly effects both humans and dogs. Protein arginine methyltransferase 5 (PRMT5), an enzyme that catalyzes the symmetric di-methylation of argini
Externí odkaz:
https://doaj.org/article/d1c4a31ca6364acf832569091ac5b711
Autor:
Jonathan Rios-Doria, Margaret Favata, Kerri Lasky, Patricia Feldman, Yvonne Lo, Gengjie Yang, Christina Stevens, Xiaoming Wen, Sarita Sehra, Kamna Katiyar, Ke Liu, Richard Wynn, Jennifer J. Harris, Min Ye, Susan Spitz, Xiaozhao Wang, Chunhong He, Yun-Long Li, Wenqing Yao, Maryanne Covington, Peggy Scherle, Holly Koblish
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
TYRO3, AXL, and MERTK constitute the TAM family of receptor tyrosine kinases, which play important roles in tumor growth, survival, cell adhesion, as well as innate immunity, phagocytosis, and immune-suppressive activity. Therefore, targeting both AX
Externí odkaz:
https://doaj.org/article/8d1cee9d42734905aea555ac4d51cd11
Autor:
Phillip C C Liu, Holly Koblish, Liangxing Wu, Kevin Bowman, Sharon Diamond, Darlise DiMatteo, Yue Zhang, Michael Hansbury, Mark Rupar, Xiaoming Wen, Paul Collier, Patricia Feldman, Ronald Klabe, Krista A Burke, Maxim Soloviev, Christine Gardiner, Xin He, Alla Volgina, Maryanne Covington, Bruce Ruggeri, Richard Wynn, Timothy C Burn, Peggy Scherle, Swamy Yeleswaram, Wenqing Yao, Reid Huber, Gregory Hollis
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231877 (2020)
Alterations in fibroblast growth factor receptor (FGFR) genes have been identified as potential driver oncogenes. Pharmacological targeting of FGFRs may therefore provide therapeutic benefit to selected cancer patients, and proof-of-concept has been
Externí odkaz:
https://doaj.org/article/f6f5510fe9c645f98e36ce8e4425a929
Autor:
Gregory Hollis, Wenqing Yao, Reid Huber, Peggy Scherle, Jeff Jackson, Swamy Yeleswaram, Cindy Marando, Ryan Geschwindt, Pramod Thekkat, Yue Zhang, Christina Stevens, Luping Lin, Darlise DiMatteo, Mark Rupar, Gengjie Yang, Chrysi Kanellopoulou, Stephen Rubin, Kevin O'Hayer, Maxim Soloviev, Sharon Diamond, Jingwei Li, Yan-ou Yang, Maryanne Covington, Elham Behshad, Kanishk Kapilashrami, Nina Zolotarjova, Alla Volgina, Hao Liu, Susan Spitz, Jonathan Rios-Doria, Richard Wynn, Phillip C.C. Liu, Liang-Chuan S. Wang, Liangxing Wu, Holly K. Koblish
Supplementary Figure from Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170fab3f863c9be0aad6f9e19f25879b
https://doi.org/10.1158/2159-8290.22540984.v1
https://doi.org/10.1158/2159-8290.22540984.v1
Autor:
Gregory Hollis, Wenqing Yao, Reid Huber, Peggy Scherle, Jeff Jackson, Swamy Yeleswaram, Cindy Marando, Ryan Geschwindt, Pramod Thekkat, Yue Zhang, Christina Stevens, Luping Lin, Darlise DiMatteo, Mark Rupar, Gengjie Yang, Chrysi Kanellopoulou, Stephen Rubin, Kevin O'Hayer, Maxim Soloviev, Sharon Diamond, Jingwei Li, Yan-ou Yang, Maryanne Covington, Elham Behshad, Kanishk Kapilashrami, Nina Zolotarjova, Alla Volgina, Hao Liu, Susan Spitz, Jonathan Rios-Doria, Richard Wynn, Phillip C.C. Liu, Liang-Chuan S. Wang, Liangxing Wu, Holly K. Koblish
Blocking the activity of the programmed cell death protein 1 (PD-1) inhibitory receptor with therapeutic antibodies against either the ligand (PD-L1) or PD-1 itself has proven to be an effective treatment modality for multiple cancers. Contrasting wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6486db56a65286928bd5907136280e12
https://doi.org/10.1158/2159-8290.c.6549529
https://doi.org/10.1158/2159-8290.c.6549529
Autor:
Gregory Hollis, Wenqing Yao, Reid Huber, Peggy Scherle, Jeff Jackson, Swamy Yeleswaram, Cindy Marando, Ryan Geschwindt, Pramod Thekkat, Yue Zhang, Christina Stevens, Luping Lin, Darlise DiMatteo, Mark Rupar, Gengjie Yang, Chrysi Kanellopoulou, Stephen Rubin, Kevin O'Hayer, Maxim Soloviev, Sharon Diamond, Jingwei Li, Yan-ou Yang, Maryanne Covington, Elham Behshad, Kanishk Kapilashrami, Nina Zolotarjova, Alla Volgina, Hao Liu, Susan Spitz, Jonathan Rios-Doria, Richard Wynn, Phillip C.C. Liu, Liang-Chuan S. Wang, Liangxing Wu, Holly K. Koblish
Supplementary Table from Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76bbcf100cd3199695d65a7a2d3df77e
https://doi.org/10.1158/2159-8290.22540981.v1
https://doi.org/10.1158/2159-8290.22540981.v1
Autor:
Gregory Hollis, Wenqing Yao, Reid Huber, Peggy Scherle, Jeff Jackson, Swamy Yeleswaram, Cindy Marando, Ryan Geschwindt, Pramod Thekkat, Yue Zhang, Christina Stevens, Luping Lin, Darlise DiMatteo, Mark Rupar, Gengjie Yang, Chrysi Kanellopoulou, Stephen Rubin, Kevin O'Hayer, Maxim Soloviev, Sharon Diamond, Jingwei Li, Yan-ou Yang, Maryanne Covington, Elham Behshad, Kanishk Kapilashrami, Nina Zolotarjova, Alla Volgina, Hao Liu, Susan Spitz, Jonathan Rios-Doria, Richard Wynn, Phillip C.C. Liu, Liang-Chuan S. Wang, Liangxing Wu, Holly K. Koblish
Supplementary Data from Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5739e2f7911a281a155113d1f5d765bd
https://doi.org/10.1158/2159-8290.22540987
https://doi.org/10.1158/2159-8290.22540987