Výsledky vyhledávání - "Peggy, Engelhard"

Akademický článek

Type I Interferon, Induced by Adenovirus or Adenoviral Vector Infection, Regulates the Cytokine Response to Lipopolysaccharide in a Macrophage Type-Specific Manner

Publikováno v: Journal of Innate Immunity, Vol 16, Iss 1, Pp 226-247 (2024)

Introduction: While TLR ligands derived from microbial flora and pathogens are important activators of the innate immune system, a variety of factors such as intracellular bacteria, viruses, and parasites can induce a state of hyperreactivity, causin

Externí odkaz: https://doaj.org/article/4a637df08c67471d97a5e4445d10d3e1

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Akademický článek

Pro-Fibrotic Effects of CCL18 on Human Lung Fibroblasts Are Mediated via CCR6

Autor: Kerstin Höhne, Annett Wagenknecht, Corinna Maier, Peggy Engelhard, Torsten Goldmann, Stephan J. Schließmann, Till Plönes, Martin Trepel, Hermann Eibel, Joachim Müller-Quernheim, Gernot Zissel

Publikováno v: Cells, Vol 13, Iss 3, p 238 (2024)

Background: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown origin, with a median patient survival time of ~3 years after diagnosis without anti-fibrotic therapy. It is characterized by progressive fibrosis indicated by increas

Externí odkaz: https://doaj.org/article/10102b1572804799b83ef55da15bba37

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Akademický článek

Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis

Autor: Benedikt Jaeger, Jonas Christian Schupp, Linda Plappert, Oliver Terwolbeck, Nataliia Artysh, Gian Kayser, Peggy Engelhard, Taylor Sterling Adams, Robert Zweigerdt, Henning Kempf, Stefan Lienenklaus, Wiebke Garrels, Irina Nazarenko, Danny Jonigk, Malgorzata Wygrecka, Denise Klatt, Axel Schambach, Naftali Kaminski, Antje Prasse

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

The functional role of airway basal cells has not been comprehensively studied in idiopathic pulmonary fibrosis (IPF). Here, the authors show that airway basal cells of IPF patients display a distinct phenotype, are profibrotic if transplanted to mic

Externí odkaz: https://doaj.org/article/107b6a818628494fa216ab22d702c61d

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Akademický článek

Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages

Autor: Mareike D. Maler, Peter J. Nielsen, Nicole Stichling, Idan Cohen, Zsolt Ruzsics, Connor Wood, Peggy Engelhard, Maarit Suomalainen, Ildiko Gyory, Michael Huber, Joachim Müller-Quernheim, Wolfgang W. A. Schamel, Siamon Gordon, Thilo Jakob, Stefan F. Martin, Willi Jahnen-Dechent, Urs F. Greber, Marina A. Freudenberg, György Fejer

Publikováno v: mBio, Vol 8, Iss 4 (2017)

ABSTRACT The scavenger receptor MARCO is expressed in several subsets of naive tissue-resident macrophages and has been shown to participate in the recognition of various bacterial pathogens. However, the role of MARCO in antiviral defense is largely

Externí odkaz: https://doaj.org/article/9c98ffb98e534f1895fead53be5d0402

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Airway basal cells show a dedifferentiated KRT17

Autor: Benedikt, Jaeger, Jonas Christian, Schupp, Linda, Plappert, Oliver, Terwolbeck, Nataliia, Artysh, Gian, Kayser, Peggy, Engelhard, Taylor Sterling, Adams, Robert, Zweigerdt, Henning, Kempf, Stefan, Lienenklaus, Wiebke, Garrels, Irina, Nazarenko, Danny, Jonigk, Malgorzata, Wygrecka, Denise, Klatt, Axel, Schambach, Naftali, Kaminski, Antje, Prasse

Publikováno v: Nature communications. 13(1)

Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. In this study, we focus on the properties of airway basal cells (ABC) obtained from patients with IPF (IPF-ABC). Single cell RNA sequencing (scRNAseq) of bronchial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df8d6e051e40ece19b8910c517136a8e
https://pubmed.ncbi.nlm.nih.gov/36163190

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The NLRP3 inflammasome pathway is activated in sarcoidosis and involved in granuloma formation

Autor: Christine Huppertz, Tobias Welte, Franz-Georg Bauernfeind, Benedikt Jäger, Veit Hornung, Peggy Engelhard, Antje Prasse, Amanda Littlewood-Evans, Grazyna Wieczorek, Stephen John Oliver

Publikováno v: European Respiratory Journal. 55:1900119

Sarcoidosis is a disease characterised by granuloma formation. There is an unmet need for new treatment strategies beyond corticosteroids. The NLRP3 inflammasome pathway is expressed in innate immune cells and senses danger signals to elicit inflamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0da89ef5efc0d4b68ec1b4b0efb9b5
https://doi.org/10.1183/13993003.00119-2019

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