Výsledky vyhledávání - "Peferoen-Baert Regina"

Akademický článek

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

Autor: van Horssen Jack, Singh Shailender, van der Pol Susanne, Kipp Markus, Lim Jamie L, Peferoen Laura, Gerritsen Wouter, Kooi Evert-Jan, Witte Maarten E, Geurts Jeroen JG, de Vries Helga E, Peferoen-Baert Regina, van den Elsen Peter J, van der Valk Paul, Amor Sandra

Publikováno v: Journal of Neuroinflammation, Vol 9, Iss 1, p 156 (2012)

Abstract Background In brain tissues from multiple sclerosis (MS) patients, clusters of activated HLA-DR-expressing microglia, also referred to as preactive lesions, are located throughout the normal-appearing white matter. The aim of this study was

Externí odkaz: https://doaj.org/article/904f5530a2c44ddd803b9252155bf4f6

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Additional file 5 of Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter

Autor: Miedema, Anneke, Gerrits, Emma, Brouwer, Nieske, Jiang, Qiong, Kracht, Laura, Meijer, Michel, Nutma, Erik, Peferoen-Baert, Regina, Pijnacker, Anna T. E., Wesseling, Evelyn M., Wijering, Marion H. C., Gabius, Hans-Joachim, Amor, Sandra, Eggen, Bart J. L., Kooistra, Susanne M.

Additional file 5: Figure S5. Supplementary data related to figure 5. Representative images of immunohistochemistry for HLA-DR, LGALS1, ASAH1 and FCGR2B in CTR donors and 6 lesion types in MS donors. Abbreviations: CWM = control white matter (CTR don

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0285dd34c1bb718d863ec223b76f0eb9

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Additional file 2 of Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter

Additional file 2: Figure S2. Supplementary data related to figure 3. (a) Representative plots depicting FACS strategy to obtain live CD45posCD11Bpos cells. (b) Boxplots per sample depicting several indicated quality control parameters per cell. (c)

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Additional file 1 of Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter

Additional file 1: Figure S1. Supplementary data related to figures 1 and 2. (a) Representative images of DAB staining for PLP and HLA-DR that was used for sample scoring. (b) Heatmap depicting gene expression of a manually chosen set of immediate-ea

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Additional file 3 of Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter

Additional file 3: Figure S3. Supplementary data related to figure 3. (a) Volcano plot depicting significantly differentially expressed genes between Hs8 and Hs6 samples. (b) Bar plots depicting top 20 gene ontology terms associated with DEGs between

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Additional file 4 of Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter

Additional file 4: Figure S4. Supplementary data related to figure 4. (a) Representative plots depicting FACS strategy to obtain live Cx3cr1pos cells. (b) Boxplots per sample depicting several QC indicated stats per cell. (c) Dot plot depicting expre

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Additional file 1: of Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter

Autor: Peferoen, Laura, Gerritsen, Wouter, Breur, Marjolein, Ummenthum, Kimberley, Peferoen-Baert, Regina, Valk, Paul Van Der, Noort, Johannes Van, Amor, Sandra

Figure S1. Representative images of white matter tissues from the same non-neurological control and MS cases as used to examine expression of other small HSPs. Double immunohistochemistry staining for HLA-DR (pink) and HSPB5 (brown). Control white ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303b525a01906dc311567477af0bd746

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