Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells.

Autor: Jin H; Medicinal Chemistry Core, Oregon Health & Science University, Portland, OR, 97239, USA., Ladd NA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, 60637, USA., Peev AM; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, 60637, USA., Swarbrick GM; Division of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, 97239, USA., Cansler M; Division of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, 97239, USA., Null M; Division of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, 97239, USA., Boughter CT; Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL, 60637, USA., McMurtrey C; PureMHC LLC, Oklahoma City, OK, 73104, USA., Nilsen A; Medicinal Chemistry Core, Oregon Health & Science University, Portland, OR, 97239, USA.; VA Portland Health Care System, Portland, OR, 97239, USA., Dobos KM; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, 80523, USA., Hildebrand WH; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA., Lewinsohn DA; Division of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, 97239, USA.; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 97239, USA., Adams EJ; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, 60637, USA., Lewinsohn DM; Division of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, 97239, USA.; VA Portland Health Care System, Portland, OR, 97239, USA.; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 97239, USA., Harriff MJ; VA Portland Health Care System, Portland, OR, 97239, USA. harriffm@ohsu.edu.; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 97239, USA. harriffm@ohsu.edu.; Division of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA. harriffm@ohsu.edu.

Publikováno v: Scientific reports [Sci Rep] 2022 Dec 29; Vol. 12 (1), pp. 22539. Date of Electronic Publication: 2022 Dec 29.