Dose Optimization of Amikacin in the Emergency Department: A Population Pharmacokinetics Simulation Study.

Autor: Dia N; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven., De Winter S; Pharmacy Department, University Hospitals Leuven., Gijsen M; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven.; Pharmacy Department, University Hospitals Leuven., Desmet S; University Hospitals Leuven, National Reference Centre for Streptococcus Pneumonia.; Department of Microbiology, Immunology and Transplantation, KU Leuven; and., Vanbrabant P; Department of Microbiology, Immunology and Transplantation, KU Leuven; and.; Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium., Peetermans W; Department of Microbiology, Immunology and Transplantation, KU Leuven; and.; Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium., Spriet I; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven.; Pharmacy Department, University Hospitals Leuven., Dreesen E; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven.

Publikováno v: Therapeutic drug monitoring [Ther Drug Monit] 2024 Dec 03. Date of Electronic Publication: 2024 Dec 03.

Treatment of non-constipated irritable bowel syndrome with the histamine 1 receptor antagonist ebastine: a randomised, double-blind, placebo-controlled trial.

Autor: Decraecker L; Department of Chronic Diseases, Metabolism, and Ageing, KU Leuven, Leuven, Belgium., De Looze D; Department of Gastroenterology and Hepatology, UZ Gent, Gent, Belgium., Hirsch DP; Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands., De Schepper H; Department of Translational Research in Immunology and Inflammation, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.; Department of Gastroenterology and Hepatology, University Hospital Antwerp, Edegem, Belgium., Arts J; Department of Gastroenterology, AZ Sint-Lucas Brugge, Brugge, Belgium.; Department of Gastroenterology and Hepatology, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Belgium., Caenepeel P; Department of Gastroenterology and Hepatology, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Belgium.; Department of Gastroenterology, Ziekenhuis Oost-Limburg - Campus Sint Jan, Genk, Belgium., Bredenoord AJ; Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Kolkman J; Department of Gastroenterology, Medisch Spectrum Twente, Enschede, The Netherlands., Bellens K; Department of Chronic Diseases, Metabolism, and Ageing, KU Leuven, Leuven, Belgium.; Department of Gastroenterology and Hepatology, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Belgium., Van Beek K; Clinical Trial Center, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Belgium., Pia F; Department of Chronic Diseases, Metabolism, and Ageing, KU Leuven, Leuven, Belgium., Peetermans W; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; Department of Internal Medicine, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Belgium., Vanuytsel T; Department of Chronic Diseases, Metabolism, and Ageing, KU Leuven, Leuven, Belgium.; Department of Gastroenterology and Hepatology, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Belgium., Denadai-Souza A; Department of Chronic Diseases, Metabolism, and Ageing, KU Leuven, Leuven, Belgium., Belmans A; Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium., Boeckxstaens G; Department of Chronic Diseases, Metabolism, and Ageing, KU Leuven, Leuven, Belgium guy.boeckxstaens@kuleuven.be.; Department of Gastroenterology and Hepatology, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Belgium.

Publikováno v: Gut [Gut] 2024 Feb 23; Vol. 73 (3), pp. 459-469. Date of Electronic Publication: 2024 Feb 23.

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Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection

Autor: Wilcox, M. H., Gerding, D. N., Poxton, I. R., Kelly, C., Nathan, R., Birch, T., Cornely, O. A., Rahav, G., Bouza, E., Lee, C., Jenkin, G., Jensen, W., Kim, Y. -S., Yoshida, J., Gabryelski, L., Pedley, A., Eves, K., Tipping, R., Guris, D., Kartsonis, N., Playford G, Dorr M. -B., Mcgechie, D, Iredell, J, Allworth, A, Cheng, A, Choi, Nj, Thalhammer, F, Maieron, A, Wenisch, C, Meyer, B, Jacobs, F, Delmee, M, Peetermans, W, Giot, Jb, Munhoz, Al, Kallas, Eg, Ladeira, Jp, Bernstein, Cn, Grimard, D, Mcgeer, A, Poirier, A, Valiquette, L, Miller, M, Oughton, M, Trottier, S, Dolce, P, Smyth, D, Gambra, P, Palma, S, Rojas, L, Northland, R, Arellano, Mc, Perez, J, Barreto, Mf, Gomez, Jm, Ramirez, I, Correa, A, Onate, J, Rohacova, H, Stastnik, M, Zjevikova, A, Blazek, J, Kumpel, P, Petersen, Am, Gluud, Ll, Staugaard, Hm, Tvede, M, Glerup, H, Madsen, Sm, Helms, M, Naumann, R, Karthaus, M, Reinshagen, M, Raz, R, Giladi, M, Chowers, M, Bishara, J, Quirino, T, Castelli, F, Bassetti, M, Rizzardini, G, Vismara, E, Puoti, M, Viale, P, Menichetti, F, Cauda, R, Bonfanti, P, Franzetti, F, Gori, A, Minoli, L, Noriega, Er, Mills, Gd, Ritchie, S, Burns, A, Pithie, A, dos Santos RM, Aldomiro, F, Fernando, Pb, Rola, J, Reis, E, Van Zyl JH, Aboo, N, Richards, G, Hernandez, Mj, de Medrano VA, Prunonosa, Lm, Gonzalez, Jl, Reinoso, Jc, Martinez, Ar, Cisneros, Jd, Banos, Jr, Sheridan, R, Minton, J, Williams, J, Stanley, P, Guleri, A, Llewelyn, M, Todd, N, Barlow, G, Bacon, Ae, Baird, Im, Baxter, R, Zenilman, Jm, Beshay, M, Betts, Rf, Brettholz, Em, Buitrago, Mi, Carlson, Rw, Cook, Pp, Dupont, Hl, Foley, C, Freilich, B, Giron, Ja, Golan, Y, Green, S, Hall, Mc, Johnson, Dj, Jones, Rk, Graham, Dr, Kazimir, M, Keating, M, Brumble, Lm, Kumar, Pn, Liappis, Ap, Libke, R, Mehra, Pk, Overcash, Sj, Mullane, Km, Nguyen, Mh, Patel, Mc, Powers, Ck, Pullman, J, Keegan, J, Nepal, S, English, G, Ricci, Rl, Risi, Gf, Rodriguez, M, Schmitt, Cm, Sims, Md, Kamepalli, R, Tural, A, Vazquez, Ja, Alangaden, Gj, Weavind, Lm, Young, Ma, Chen, St, Liu, E, Nguyen, Hh, Alfonso, Tb, Muse, Dd, Orenstein, R, Yacyshyn, B, Gebhard, Re, Dinges, W, Bolton, M, Rubin, M, Kuemmerle, Jf, Limaye, Ap, Friedenberg, Ka, Hiemenz, Jw, Quadri, A, Martinez, Jv, Barcan, La, Cordova, E, Mykietiuk, A, Losso, M, Fedorak, Rn, Steiner, T, Gerson, M, Weiss, K, Dlouhy, P, Vitous, A, Benes, J, Husa, P, Knizek, P, Anttila, Vj, Broas, M, Camou, F, Postil, D, Launay, O, Corroyer-Simovic, B, Meynard, Jl, Schneider, S, Molina, Jm, Neau, D, Zalcman, G, Boutoille, D, Ostermann, H, Heinz, W, Reuter, S, Oren, I, Schiff, E, Umemoto, T, Masubuchi, T, Mukawa, K, Yasuda, K, Imokawa, S, Fukuda, K, Ohta, H, Harada, N, Fujii, S, Tamaki, S, Yasui, S, Furukawa, K, Takahashi, M, Uraoka, T, Watanabe, M, Ikehara, Y, Kodaira, M, Komatsu, H, Higashi, K, Taguchi, F, Ura, N, Serizawa, Y, Fukuchi, T, Ashikawa, T, Shabana, M, Okubo, M, Matsumoto, M, Kurihara, A, Miyasaka, E, Shimizu, M, Tominaga, H, Kubota, T, Kashiwazaki, M, Masuda, Y, Terasaki, S, Okafuji, H, Mieno, H, Urabe, T, Okamoto, E, Kajimura, M, Yamagishi, Y, Rydzewska, G, Mach, T, Ciechanowski, K, Podlasin, R, Tomasiewicz, K, Janczewska-Kazek, E, Czarnobilski, K, Halota, W, Gryglewska, B, Plesniak, R, Dabrowiecki, P, Lipowski, D, Simanenkov, V, Shcheglova, L, Uspenskiy, Y, Cheganov, A, Han, Ds, Kim, Js, Hong, Sp, Kim, Ti, Jang, Bi, Byeon, Js, Kim, E, Kim, Mj, Lee, J, Pai, H, Cheong, Hj, Lee, S, Loyarte, Ja, Gonzalez, Jc, Santiago, Eb, Lopez, Jr, Baranda, Jm, Viladomiu, As, Calbo, E, Lannergard, A, Falt, J, Gardlund, B, Andersson, Lm, Fraenkel, Cj, Rombo, L, Widmer, A, Chen, Yc, Sheng, Wh, Wang, Fd, Wang, Nc, Lee, Ch, Chen, Yh, Chuang, Yc, Unal, S, Ozaras, R, Esen, S, Ural, O, Ayaz, C, Sakarya, S, Celebi, A, Mistik, R, Bedimo, R, Bressler, A, Mckinley, Mj, Quirk, D, Talansky, Al, Agronin, Me, Akhrass, Fa, Ali, M, Alrabaa, Sf, Assi, Ma, Calfee, Dp, Carson, P, Mariani, Pg, Guerrero, D, Dubberke, Er, Hardi, R, Hazan-Steinberg, S, Itani, Km, Jauregui-Peredo, El, Kasabji, A, Hameed, M, Murillo, A, Odio, Aj, Shah, P, Braun, Ti, Slim, J, Sloan, L, Srinivasan, S, Tan, Mj, Clough, La, Herr, D, Miller, Lg, Dorfmeister, J, Khan, O, Melik-Abrahamian, F.

Publikováno v: Wilcox, M H, Gerding, D N, Poxton, I R, Kelly, C, Nathan, R, Birch, T, Cornely, O A, Rahav, G, Bouza, E, Lee, C, Jenkin, G, Jensen, W, Kim, Y-S, Yoshida, J, Gabryelski, L, Pedley, A, Eves, K, Tipping, R, Guris, D, Kartsonis, N, Dorr, M-B, MODIFY I and MODIFY II Investigators & Glerup, H 2017, ' Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection ', The New England Journal of Medicine, vol. 376, no. 4, pp. 305-317 . https://doi.org/10.1056/NEJMoa1602615

BACKGROUND: Clostridium difficile is the most common cause of infectious diarrhea in hospitalized patients. Recurrences are common after antibiotic therapy. Actoxumab and bezlotoxumab are human monoclonal antibodies against C. difficile toxins A and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bc273f9f36169cf744b9e7b515f01e
http://hdl.handle.net/11568/1022277

Quantification and Explanation of the Variability of First-Dose Amikacin Concentrations in Critically Ill Patients Admitted to the Emergency Department: A Population Pharmacokinetic Analysis.

Autor: De Winter S; Department of Pharmacy, Univesity Hospitals Leuven, Leuven, Belgium. sabrina.dewinter@uzleuven.be., van Hest R; Department of Hospital Pharmacy and Clinical Pharmacology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Dreesen E; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Annaert P; Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, KU Leuven, Leuven, Belgium.; BioNotus, Galileilaan 15, 2845, Niel, Belgium., Wauters J; Department of Internal Medicine, University Hospitals Leuven, Leuven, Belgium., Meersseman W; Department of Internal Medicine, University Hospitals Leuven, Leuven, Belgium., Van den Eede N; Laboratory of Clinical Bacteriology and Mycology, University Hospitals Leuven, Leuven, Belgium., Desmet S; Laboratory of Clinical Bacteriology and Mycology, University Hospitals Leuven, Leuven, Belgium., Verelst S; Department of Emergency Medicine, University Hospitals Leuven, Leuven, Belgium., Vanbrabant P; Department of Internal Medicine, University Hospitals Leuven, Leuven, Belgium., Peetermans W; Department of Internal Medicine, University Hospitals Leuven, Leuven, Belgium., Spriet I; Department of Pharmacy, Univesity Hospitals Leuven, Leuven, Belgium.; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

Publikováno v: European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2021 Sep; Vol. 46 (5), pp. 653-663. Date of Electronic Publication: 2021 Jul 23.