Noise suppression of proton magnetic resonance spectroscopy improves paediatric brain tumour classification.

Autor: Zhao T; Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Oncology, Birmingham Children's Hospital, Birmingham, UK., Grist JT; Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Auer DP; Clinical Neuroscience, University of Nottingham, Nottingham, UK., Avula S; Radiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK., Bailey S; Paediatric Oncology, Great North Children's Hospital, Newcastle upon Tyne, UK., Davies NP; Imaging and Medical Physics, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Grundy RG; Clinical Neuroscience, University of Nottingham, Nottingham, UK., Khan O; Digital Healthcare, WMG, University of Warwick, Coventry, UK., MacPherson L; Radiology, Birmingham Children's Hospital, Birmingham, UK., Morgan PS; Clinical Neuroscience, University of Nottingham, Nottingham, UK.; Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK.; Medical Physics, Nottingham University Hospitals NHS Trust, Nottingham, UK., Pizer B; University of Liverpool, Liverpool, UK., Rose HEL; Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Oncology, Birmingham Children's Hospital, Birmingham, UK., Sun Y; Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Oncology, Birmingham Children's Hospital, Birmingham, UK., Wilson M; Centre for Human Brain Health, University of Birmingham, Birmingham, UK., Worthington L; Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Oncology, Birmingham Children's Hospital, Birmingham, UK.; RRPPS, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Arvanitis TN; Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Oncology, Birmingham Children's Hospital, Birmingham, UK.; Digital Healthcare, WMG, University of Warwick, Coventry, UK.; Engineering, University of Birmingham, Birmingham, UK., Peet AC; Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Oncology, Birmingham Children's Hospital, Birmingham, UK.

Publikováno v: NMR in biomedicine [NMR Biomed] 2024 Jun; Vol. 37 (6), pp. e5129. Date of Electronic Publication: 2024 Mar 17.

Metabolite profiles of medulloblastoma for rapid and non-invasive detection of molecular disease groups.

Autor: Kohe S; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Birmingham Children's Hospital, Birmingham, UK., Bennett C; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Birmingham Children's Hospital, Birmingham, UK., Burté F; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Adiamah M; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Rose H; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Birmingham Children's Hospital, Birmingham, UK., Worthington L; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Birmingham Children's Hospital, Birmingham, UK; RRPPS, University Hospital Birmingham, Birmingham, UK., Scerif F; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., MacPherson L; Birmingham Children's Hospital, Birmingham, UK., Gill S; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Birmingham Children's Hospital, Birmingham, UK., Hicks D; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Schwalbe EC; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK., Crosier S; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Storer L; Children's Brain Tumour Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Lourdusamy A; Children's Brain Tumour Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Mitra D; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Morgan PS; Children's Brain Tumour Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Dineen RA; Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK; Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, UK., Avula S; Alder Hey Children's Hospital, Liverpool, UK., Pizer B; University of Liverpool, Liverpool, UK., Wilson M; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Birmingham Children's Hospital, Birmingham, UK., Davies N; RRPPS, University Hospital Birmingham, Birmingham, UK., Tennant D; Institute of Metabolism and Systems Research, University of Birmingham, UK., Bailey S; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Williamson D; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Arvanitis TN; Department of Electronic, Electrical and Systems Engineering, University of Birmingham, UK., Grundy RG; Children's Brain Tumour Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Clifford SC; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. Electronic address: steve.clifford@ncl.ac.uk., Peet AC; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Birmingham Children's Hospital, Birmingham, UK. Electronic address: a.peet@bham.ac.uk.

Publikováno v: EBioMedicine [EBioMedicine] 2024 Feb; Vol. 100, pp. 104958. Date of Electronic Publication: 2024 Jan 06.

Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging.

Autor: Linke F; Children's Brain Tumour Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Johnson JEC; Children's Brain Tumour Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Kern S; School of Pharmacy, University of Nottingham, Nottingham, UK., Bennett CD; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Birmingham Children's Hospital, Birmingham, UK., Lourdusamy A; Children's Brain Tumour Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Lea D; Digital Research Service, University of Nottingham, Nottingham, UK., Clifford SC; Wolfson Childhood Cancer Research Centre, Translational & Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle Upon Tyne, NE1 7RU, UK., Merry CLR; School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Stolnik S; School of Pharmacy, University of Nottingham, Nottingham, UK., Alexander MR; School of Pharmacy, University of Nottingham, Nottingham, UK., Peet AC; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Birmingham Children's Hospital, Birmingham, UK., Scurr DJ; School of Pharmacy, University of Nottingham, Nottingham, UK., Griffiths RL; School of Pharmacy, University of Nottingham, Nottingham, UK., Grabowska AM; School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Kerr ID; School of Life Sciences, University of Nottingham, Nottingham, UK., Coyle B; Children's Brain Tumour Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK. beth.coyle@nottingham.ac.uk.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Jan 11; Vol. 11 (1), pp. 6. Date of Electronic Publication: 2023 Jan 11.

Dynamic susceptibility-contrast magnetic resonance imaging with contrast agent leakage correction aids in predicting grade in pediatric brain tumours: a multicenter study.

Autor: Withey SB; RRPPS, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Oncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., MacPherson L; Radiology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK., Oates A; Radiology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK., Powell S; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Novak J; Oncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Department of Psychology, Aston Brain Centre, School of Life and Health Sciences, Aston University, Birmingham, UK., Abernethy L; Radiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK., Pizer B; Oncology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK., Grundy R; The Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK., Morgan PS; The Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK.; Medical Physics, Nottingham University Hospitals, Nottingham, UK.; Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK., Bailey S; Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, UK., Mitra D; Neuroradiology, Royal Victoria Infirmary, Newcastle upon Tyne, UK., Arvanitis TN; Oncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Institute of Digital Healthcare, WMG, University of Warwick, Coventry, UK., Auer DP; Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK.; Neuroradiology, Nottingham University Hospitals Trust, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Nottingham, UK., Avula S; Radiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK., Peet AC; Oncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK. a.peet@bham.ac.uk.; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK. a.peet@bham.ac.uk.; Children's Brain Tumour Research Team, 4th Floor Institute of Child Health, Birmingham Women's and Children's Hospital NHS Foundation Trust, Steelhouse Lane, Birmingham, B4 6NH, UK. a.peet@bham.ac.uk.

Publikováno v: Pediatric radiology [Pediatr Radiol] 2022 May; Vol. 52 (6), pp. 1134-1149. Date of Electronic Publication: 2022 Mar 15.

Combining multi-site magnetic resonance imaging with machine learning predicts survival in pediatric brain tumors.

Autor: Grist JT; Institute of Cancer and Genomic Sciences, School of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Withey S; Institute of Cancer and Genomic Sciences, School of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Oncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.; RRPPS, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Bennett C; Institute of Cancer and Genomic Sciences, School of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Rose HEL; Institute of Cancer and Genomic Sciences, School of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Oncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK., MacPherson L; Radiology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK., Oates A; Radiology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK., Powell S; Institute of Cancer and Genomic Sciences, School of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Novak J; Oncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.; Psychology, College of Health and Life Sciences Aston University, Birmingham, UK.; Aston Neuroscience Institute, Aston University, Birmingham, UK., Abernethy L; Radiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK., Pizer B; Oncology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK., Bailey S; Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, UK., Clifford SC; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, University of Newcastle, Newcastle upon Tyne, UK., Mitra D; Neuroradiology, Royal Victoria Infirmary, Newcastle Upon Tyne, UK., Arvanitis TN; Institute of Cancer and Genomic Sciences, School of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Oncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.; Institute of Digital Healthcare, WMG, University of Warwick, Coventry, UK., Auer DP; Sir Peter Mansfield Imaging Centre, University of Nottingham Biomedical Research Centre, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Nottingham, UK., Avula S; Radiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK., Grundy R; The Children's Brain Tumor Research Centre, University of Nottingham, Nottingham, UK., Peet AC; Institute of Cancer and Genomic Sciences, School of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. a.peet@bham.ac.uk.; Oncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK. a.peet@bham.ac.uk.

Publikováno v: Scientific reports [Sci Rep] 2021 Sep 23; Vol. 11 (1), pp. 18897. Date of Electronic Publication: 2021 Sep 23.