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DNA-Model-Based Design and Execution of Some Fused Benzodiazepine Hybrid Payloads for Antibody-Drug Conjugate Modality.

Autor: Sivaprakasam P; Computer-Aided Drug Design, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States., McDonald I; Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States., Iwuagwu C; Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States., Chowdari NS; Discovery Chemistry, Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States., Peese KM; Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States., Langley DR; Computer-Aided Drug Design, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States., Cheng H; Discovery Chemistry, Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States., Luzung MR; Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States., Schmidt MA; Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States., Zheng B; Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States., Tan Y; Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States., Cho P; Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States., Rakshit S; Chemical Development and API Supply, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore 560099, India., Lakshminarasimhan T; Chemical Development and API Supply, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore 560099, India., Guturi S; Chemical Development and API Supply, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore 560099, India., Kanagavel K; Chemical Development and API Supply, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore 560099, India., Kanusu U; Chemical Development and API Supply, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore 560099, India., Niyogi AG; Chemical Development and API Supply, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore 560099, India., Sidhar S; Chemical Development and API Supply, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore 560099, India., Vaidyanathan R; Chemical Development and API Supply, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore 560099, India., Eastgate MD; Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States., Kotapati S; Discovery Biotherapeutics, Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States., Deshpande M; Discovery Biotherapeutics, Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States., Pan C; Cell Biology and Pharmacology, Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States., Cardarelli PM; Cell Biology and Pharmacology, Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States., Xie C; Lead Discovery and Optimization, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08543, United States., Rao C; Discovery Biotherapeutics, Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States., Holder P; Discovery Biotherapeutics, Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States., Sarma G; Discovery Biotherapeutics, Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States., Vite G; Discovery Chemistry, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08543, United States., Gangwar S; Discovery Chemistry, Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Feb 10; Vol. 12 (3), pp. 404-412. Date of Electronic Publication: 2021 Feb 10 (Print Publication: 2021).

Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.

Autor: Peese KM; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA. Electronic address: kevin.peese@bms.com., Naidu BN; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA., Patel M; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA., Li C; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA., Langley DR; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA., Terry B; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA., Protack T; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA., Gali V; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA., Lin Z; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA., Samanta HK; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA., Zheng M; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA., Jenkins S; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA., Dicker IB; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA., Krystal MR; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA., Meanwell NA; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA., Walker MA; Departments of Discovery Chemistry and Discovery Infectious Diseases, Bristol-Myers Squibb Research & Development, Wallingford, CT 06492, USA.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Feb 01; Vol. 30 (3), pp. 126784. Date of Electronic Publication: 2019 Nov 09.

General Method for the Preparation of Electron-Deficient Imidazo[1,2-a]pyridines and Related Heterocycles.

Autor: McDonald IM; Bristol-Myers Squibb Research & Development , Department of Discovery Chemistry, 5 Research Parkway, Wallingford, Connecticut 06492, United States., Peese KM; Bristol-Myers Squibb Research & Development , Department of Discovery Chemistry, 5 Research Parkway, Wallingford, Connecticut 06492, United States.

Publikováno v: Organic letters [Org Lett] 2015 Dec 18; Vol. 17 (24), pp. 6002-5. Date of Electronic Publication: 2015 Nov 24.

New first and second generation inhibitors of human immunodeficiency virus-1 integrase.

Autor: Pendri A; Bristol-Myers Squibb, Research and Development, Department of Early Discovery, Chemistry, Wallingford 06492, USA., Meanwell NA, Peese KM, Walker MA

Publikováno v: Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2011 Aug; Vol. 21 (8), pp. 1173-89. Date of Electronic Publication: 2011 May 20.