Zobrazeno 1 - 10
of 1 021
pro vyhledávání: '"Peers, C."'
Yes
Astrocytes play a fundamental role in maintaining the health and function of the central nervous system. Increasing evidence indicates that astrocytes undergo both cellular and molecular changes at an early stage in neurological diseases, in
Astrocytes play a fundamental role in maintaining the health and function of the central nervous system. Increasing evidence indicates that astrocytes undergo both cellular and molecular changes at an early stage in neurological diseases, in
Externí odkaz:
http://hdl.handle.net/10454/11004
Yes
Ion channels represent a large and growing family of target proteins regulated by gasotransmitters such as nitric oxide, carbon monoxide and, as described more recently, hydrogen sulfide. Indeed, many of the biological actions of these gases
Ion channels represent a large and growing family of target proteins regulated by gasotransmitters such as nitric oxide, carbon monoxide and, as described more recently, hydrogen sulfide. Indeed, many of the biological actions of these gases
Externí odkaz:
http://hdl.handle.net/10454/12201
Autor:
Al-Owais, M.M., Hettiarachchi, N.T., Kirton, H.M., Hardy, Matthew E., Boyle, J.P., Scragg, J.L., Steele, D.S., Peers, C.
Yes
Exposure to CO causes early afterdepolarization arrhythmias. Previous studies in rats have indicated that arrhythmias arose as a result of augmentation of the late Na+ current. The purpose of the present study was to examine the basis for CO
Exposure to CO causes early afterdepolarization arrhythmias. Previous studies in rats have indicated that arrhythmias arose as a result of augmentation of the late Na+ current. The purpose of the present study was to examine the basis for CO
Externí odkaz:
http://hdl.handle.net/10454/16500
Autor:
Berrout, J., Kyriakopoulou, E., Moparthi, L., Hogea, A.S., Berrout, L., Ivan, C., Lorger, M., Boyle, J., Peers, C., Muench, S., Elies, Jacobo, Hu, X., Hurst, C., Hall, T., Umamaheswaran, S., Wesley, L., Gagea, M., Shires, M., Manfield, I., Knowles, M.A., Davies, S., Suhling, K., Gonzalez, Y.T., Carragher, N., Macleod, K., Abbott, N.J., Calin, G.A., Gamper, N., Zygmunt, P.M., Timsah, Z.
Yes
Recent evidence suggests that the ion channel TRPA1 is implicated in lung adenocarcinoma (LUAD) where its role and mechanism of action remain unknown. We have previously established that the membrane receptor FGFR2 drives LUAD progression th
Recent evidence suggests that the ion channel TRPA1 is implicated in lung adenocarcinoma (LUAD) where its role and mechanism of action remain unknown. We have previously established that the membrane receptor FGFR2 drives LUAD progression th
Externí odkaz:
http://hdl.handle.net/10454/12962
Autor:
Yang, Z., Kirton, H.M., MacDougall, D.A., Boyle, J.P., Deuchars, J., Frater, B., Ponnambalam, S., Hardy, Matthew E., White, M., Calaghan, S.C., Peers, C., Steele, D.S.
Yes
Ca2+ release from the Golgi apparatus regulates key functions of the organelle, including vesicle trafficking. However, the signaling pathways that control this form of Ca2+ release are poorly understood and evidence of discrete Golgi Ca2+ r
Ca2+ release from the Golgi apparatus regulates key functions of the organelle, including vesicle trafficking. However, the signaling pathways that control this form of Ca2+ release are poorly understood and evidence of discrete Golgi Ca2+ r
Externí odkaz:
http://hdl.handle.net/10454/16503
Autor:
Duckles, H., Al-Owais, M.M., Elies, Jacobo, Johnson, E., Boycott, H.E., Dallas, M.L., Porter, K.E., Boyle, J.P., Scragg, J.L., Peers, C.
T-type Ca2+ channels regulate proliferation in a number of tissue types, including vascular smooth muscle and various cancers. In such tissues, up-regulation of the inducible enzyme heme oxygenase-1 (HO-1) is often observed, and hypoxia is a key fact
Externí odkaz:
http://hdl.handle.net/10454/12225
Autor:
Elies, Jacobo, Scragg, J.L., Dallas, M.L., Huang, D., Huang, S., Boyle, J.P., Gamper, N., Peers, C.
T-type Ca2+ channels are a distinct family of low voltage-activated Ca2+ channels which serve many roles in different tissues. Several studies have implicated them, for example, in the adaptive responses to chronic hypoxia in the cardiovascular and e
Externí odkaz:
http://hdl.handle.net/10454/12224
T-type Ca2+ channels (Cav3.1, 3.2 and 3.3) strongly influence proliferation of various cell types, including vascular smooth muscle cells (VSMCs) and certain cancers. We have recently shown that the gasotransmitter carbon monoxide (CO) inhibits T-typ
Externí odkaz:
http://hdl.handle.net/10454/12205
Autor:
Peers, C., Boyle, J.P., Scragg, J.L., Dallas, M.L., Al-Owais, M.M., Hettiarachichi, N.T., Elies, Jacobo, Johnson, E., Gamper, N., Steele, D.S.
Carbon monoxide (CO) is firmly established as an important, physiological signalling molecule as well as a potent toxin. Through its ability to bind metal-containing proteins, it is known to interfere with a number of intracellular signalling pathway
Externí odkaz:
http://hdl.handle.net/10454/12204
Autor:
Duckles, H., Boycott, H.E., Al-Owais, M.M., Elies, Jacobo, Johnson, E., Dallas, M.L., Porter, K.E., Giuntini, F., Boyle, J.P., Scragg, J.L., Peers, C.
Yes
Induction of the antioxidant enzyme heme oxygenase-1 (HO-1) affords cellular protection and suppresses proliferation of vascular smooth muscle cells (VSMCs) associated with a variety of pathological cardiovascular conditions including myocar
Induction of the antioxidant enzyme heme oxygenase-1 (HO-1) affords cellular protection and suppresses proliferation of vascular smooth muscle cells (VSMCs) associated with a variety of pathological cardiovascular conditions including myocar
Externí odkaz:
http://hdl.handle.net/10454/12206