Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Peer, Lukat"'
1
Akademický článek
Biochemical and structural elucidation of the L-carnitine degradation pathway of the human pathogen Acinetobacter baumannii
Autor: Fabian Piskol, Peer Lukat, Laurin Kaufhold, Alexander Heger, Wulf Blankenfeldt, Dieter Jahn, Jürgen Moser
Publikováno v: Frontiers in Microbiology, Vol 15 (2024)
Acinetobacter baumannii is an opportunistic human pathogen which can use host-derived L-carnitine as sole carbon and energy source. Recently, an L-carnitine transporter (Aci1347) and a specific monooxygense (CntA/CntB) for the intracellular cleavage
Externí odkaz: https://doaj.org/article/24723026964341408995963a19b85573
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2
Akademický článek
Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins
Autor: Chengzhang Fu, Yunkun Liu, Christine Walt, Sari Rasheed, Chantal D. Bader, Peer Lukat, Markus Neuber, F. P. Jake Haeckl, Wulf Blankenfeldt, Olga V. Kalinina, Rolf Müller
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract DNA polymerase III sliding clamp (DnaN) was recently validated as a new anti-tuberculosis target employing griselimycins. Three (2 S,4 R)−4-methylproline moieties of methylgriselimycin play significant roles in target binding and metabolic
Externí odkaz: https://doaj.org/article/7e4cc23e8e7b46028e890b8dfe93715d
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3
Akademický článek
Eukaryotic Box C/D methylation machinery has two non-symmetric protein assembly sites
Autor: Simone Höfler, Peer Lukat, Wulf Blankenfeldt, Teresa Carlomagno
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Box C/D ribonucleoprotein complexes are RNA-guided methyltransferases that methylate the ribose 2’-OH of RNA. The central ‘guide RNA’ has box C and D motifs at its ends, which are crucial for activity. Archaeal guide RNAs have a second
Externí odkaz: https://doaj.org/article/6b06d43f8c7b44b0bfbeb0e72c36370a
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6
Protein‐Templated Hit Identification through an Ugi Four‐Component Reaction**
Autor: Jennifer Herrmann, Rolf Müller, Alaa Alhayek, Peer Lukat, Varsha R. Jumde, Wulf Blankenfeldt, M. Yagiz Unver, Matthias Köck, Martin D. Witte, Walid A. M. Elgaher, Federica Mancini, Anna K. H. Hirsch
Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry (Weinheim an der Bergstrasse, Germany)
Germany
Chemistry – A European Journal
Chemistry-A European Journal, 26(64), 14585-14593. Wiley-VCH Verlag GmbH & Co. KGaA
Kinetic target‐guided synthesis represents an efficient hit‐identification strategy, in which the protein assembles its own inhibitors from a pool of complementary building blocks via an irreversible reaction. Herein, we pioneered an in situ Ugi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f63ec047fd9b775f368655b848f6624
https://doi.org/10.1002/chem.202002250
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7
Reproducible and Easy Production of Mammalian Proteins by Transient Gene Expression in High Five Insect Cells
Autor: Maren, Schubert, Manfred, Nimtz, Federico, Bertoglio, Stefan, Schmelz, Peer, Lukat, Joop, van den Heuvel
Publikováno v: Methods in molecular biology (Clifton, N.J.). 2305
The expression of mammalian recombinant proteins in insect cell lines using transient-plasmid-based gene expression enables the production of high-quality protein samples. Here, the procedure for virus-free transient gene expression (TGE) in High Fiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5499d95571767239eca81b6dee5bbdd
https://pubmed.ncbi.nlm.nih.gov/33950387
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8
Crystal structure of bacterial cytotoxic necrotizing factor CNF Y reveals molecular building blocks for intoxication
Autor: Theresia E.B. Stradal, Paweena Chaoprasid, Wulf Blankenfeldt, Anika Steffen, Thomas Heidler, Petra Dersch, Shuangshuang Dong, Christian Rüter, Sabrina Mühlen, Peer Lukat, Wenjie Bi, Marco Kirchenwitz, Lothar Jänsch, Emerich-Mihai Gazdag
Publikováno v: The EMBO Journal
e105202
The EMBO journal
England
Cytotoxic necrotizing factors (CNFs) are bacterial single‐chain exotoxins that modulate cytokinetic/oncogenic and inflammatory processes through activation of host cell Rho GTPases. To achieve this, they are secreted, bind surface receptors to indu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c62fe8fef11fa48ebc407872f2637c1
https://doi.org/10.15252/embj.2020105202
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9
Reproducible and Easy Production of Mammalian Proteins by Transient Gene Expression in High Five Insect Cells
Autor: Manfred Nimtz, Federico Bertoglio, Joop van den Heuvel, Peer Lukat, Maren Schubert, Stefan Schmelz
Publikováno v: Methods in Molecular Biology ISBN: 9781071614051
The expression of mammalian recombinant proteins in insect cell lines using transient-plasmid-based gene expression enables the production of high-quality protein samples. Here, the procedure for virus-free transient gene expression (TGE) in High Fiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::418774de8daeaaa36b1c0093b622d9aa
https://doi.org/10.1007/978-1-0716-1406-8_6
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10
Understanding and Engineering the Stereoselectivity of Humulene Synthase
Autor: Peer Lukat, Wulf Blankenfeldt, Russell J. Cox, Carsten Schotte, Adrian Deuschmann
Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie / International edition 60(37), 20308-20312 (2021). doi:10.1002/anie.202106718
Angewandte Chemie / International edition 60(37), 20308 - 20312 (2021). doi:10.1002/anie.202106718
The non-canonical terpene cyclase AsR6 is responsible for the formation of 2E,6E,9E-humulene during the biosynthesis of the tropolone sesquiterpen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01cdae6a32c4b921318dacfa8806a37
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