Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Peedikayil E. Thomas"'
Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline
Autor:
Saher Sue Hammoud, Aniela Crayton, Jacqueline Graniel, Peedikayil E. Thomas, Leolene J Carrington, Catherine E. Keegan, Joshua D Brandstadter, Jayakrishnan Nandakumar, Adrienne Niederriter Shami, James J. White, Kamlesh Bisht, Alina Moroz, Jennifer Chase, Frederick Allen, Ann Friedman, Eric Perkey, Ivan Maillard, Anna Mychalowych, Mariel Manzor, Ashley Vanderbeck
Publikováno v:
Life Science Alliance
A TPP1 mutation known to cause telomere shortening and bone marrow failure in humans recapitulates telomere loss but results in severe germline defects in mice without impacting murine hematopoiesis.
Telomerase extends chromosome ends in somatic
Telomerase extends chromosome ends in somatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f399ba0af60580eccc81bcad6af3e0
https://doi.org/10.1101/2021.07.29.454392
https://doi.org/10.1101/2021.07.29.454392
Autor:
Jessica A Lehoczky, Peedikayil E Thomas, Kevin M Patrie, Kailey M Owens, Lisa M Villarreal, Kenneth Galbraith, Joe Washburn, Craig N Johnson, Bryant Gavino, Alexander D Borowsky, Kathleen J Millen, Paul Wakenight, William Law, Margaret L Van Keuren, Galina Gavrilina, Elizabeth D Hughes, Thomas L Saunders, Lesil Brihn, Joseph H Nadeau, Jeffrey W Innis
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1003967 (2013)
Mouse early transposon insertions are responsible for ~10% of spontaneous mutant phenotypes. We previously reported the phenotypes and genetic mapping of Polypodia, (Ppd), a spontaneous, X-linked dominant mutation with profound effects on body plan m
Externí odkaz:
https://doaj.org/article/7e2168f239154d7b8e91247117543900
Autor:
Ceren Sucularli, James S. White, Hande Kocak, Bridget C. O’Connor, Peedikayil E. Thomas, Catherine E. Keegan
Publikováno v:
Gene. 679:219-231
In mammalian cells TPP1, encoded by the Acd gene, is a key component of the Shelterin complex, which is required for telomere length maintenance and telomere protection. In mice, a hypomorphic mutation in Acd causes the adrenocortical dysplasia (acd)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bad62dbb8e49e7b9a925ef828480f18
https://doi.org/10.1016/j.gene.2018.09.002
https://doi.org/10.1016/j.gene.2018.09.002
Autor:
Melis Sahinoz, Ashley J. Cuttitta, Sandra Camelo-Piragua, Graham F. Brady, Rasimcan Meral, Marwan K. Tayeh, Amit R. Rupani, Shafaq Khairi, Peedikayil E. Thomas, Meredith P. Riebschleger, Jeffrey W. Innis, M. Bishr Omary, Elif A. Oral, Daniel E. Michele
Publikováno v:
Clinical Diabetes and Endocrinology, Vol 4, Iss 1, Pp 1-6 (2018)
Clinical Diabetes and Endocrinology
Clinical Diabetes and Endocrinology
Background Juvenile dermatomyositis (JDM) is an auto-immune muscle disease which presents with skin manifestations and muscle weakness. At least 10% of the patients with JDM present with acquired lipodystrophy. Laminopathies are caused by mutations i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fa10fbd555b2638aeb7c696a86acd3
http://link.springer.com/article/10.1186/s40842-018-0058-3
http://link.springer.com/article/10.1186/s40842-018-0058-3
Autor:
James S. White, John Hensley, Benjamin L. Allen, Catherine E. Keegan, Anya Kiseleva, Peter Orchard, Peedikayil E. Thomas, Stephen C. J. Parker, Anna Mychalowych
Danforth’s short tail(Sd)mice provide an excellent model for investigating the underlying etiology of human caudal birth defects, which affect 1 in 10,000 live births.Sdanimals exhibit aberrant axial skeleton, urogenital, and gastrointestinal devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe02a7d97d35e8863b21e07f10b09dd
https://doi.org/10.1101/387977
https://doi.org/10.1101/387977
Autor:
Peedikayil E. Thomas, Thomas L. Chenevert, Amit R. Rupani, Frank DiPaola, Colleen Buggs-Saxton, M. Bishr Omary, Adam H. Neidert, Eric D. Buras, Rasimcan Meral, Graham F. Brady, Jeffrey W. Innis, Marwan K. Tayeh, Nevin Ajluni, Elif A. Oral, Barbara J. McKenna, Hari S. Conjeevaram, Jeffrey F. Horowitz
Publikováno v:
Clinical endocrinology. 86(5)
SummaryContext Partial lipodystrophy (PL) is associated with metabolic co-morbidities but may go undiagnosed as the disease spectrum is not fully described. Objective The objective of the study was to define disease spectrum in PL using genetic, clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441217aa1dc5c4ddd7fa1b7396652420
https://pubmed.ncbi.nlm.nih.gov/28199729
https://pubmed.ncbi.nlm.nih.gov/28199729
Autor:
Kevin M. Vannella, Ryan P. Charbeneau, Marc Peters-Golden, Bethany B. Moore, Galen B. Toews, Peedikayil E. Thomas, Carol A. Wilke, Tracy R. McMillan
Publikováno v:
The Journal of Immunology. 179:7883-7890
Pulmonary fibrosis is characterized by the accumulation of fibroblasts and myofibroblasts. These cells may accumulate from three potential sources: the expansion of resident lung fibroblasts, the process of epithelial-mesenchymal transition, or the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fcc0fb7f090cbd3e45d01dbac680aed
https://doi.org/10.4049/jimmunol.179.11.7883
https://doi.org/10.4049/jimmunol.179.11.7883
Autor:
Zongbin Cui, Jeffrey C. Horowitz, Meghna Waghray, Venkateshwar G. Keshamouni, Daniel Y. Lee, Victor J. Thannickal, Hengmin Zhang, Peedikayil E. Thomas
Publikováno v:
Journal of Biological Chemistry. 279:1359-1367
Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine involved in differentiation, growth, and survival of mesenchymal cells while inhibiting growth/survival of most other cell types. The mechanism(s) of pro-survival signaling by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993178c8b4a7337d8f002934d95564a9
https://doi.org/10.1074/jbc.m306248200
https://doi.org/10.1074/jbc.m306248200
Autor:
Eric S. White, Jose M. Larios, Zongbin Cui, Regina M. Day, Jeffrey C. Horowitz, Victor J. Thannickal, Raquel Chacon, Peedikayil E. Thomas, Daniel Y. Lee
Publikováno v:
Journal of Biological Chemistry. 278:12384-12389
Myofibroblast differentiation and activation by transforming growth factor-beta1 (TGF-beta1) is a critical event in the pathogenesis of human fibrotic diseases, but regulatory mechanisms for this effect are unclear. In this report, we demonstrate tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467404ea770136656bb57fa99657f681
https://doi.org/10.1074/jbc.m208544200
https://doi.org/10.1074/jbc.m208544200
Autor:
Peedikayil E. Thomas, Rajaram Gopalakrishnan, Dian Wang, Renny T. Franceschi, M. Douglas Benson
Publikováno v:
Connective Tissue Research. 44:154-160
Bone sialoprotein (BSP) expression is restricted to cells associated with the mineralization of bones and teeth. We previously identified a homeodomain binding element in a 2.5 kb fragment of the murine Bsp promoter that is required for osteoblast-se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15071961a9df07963132ad03d7da365c
https://doi.org/10.1080/03008200390152250
https://doi.org/10.1080/03008200390152250