Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity

Autor: Rached, Marie-Therese, Millership, Steven J, Pedroni, Silvia MA, Choudhury, Agharul I, Costa, Ana SH, Hardy, Darran G, Glegola, Justyna A, Irvine, Elaine E, Selman, Colin, Woodberry, Megan C, Yadav, Vijay K, Khadayate, Sanjay, Vidal-Puig, Antonio, Virtue, Samuel, Frezza, Christian, Withers, Dominic J

Publikováno v: Molecular Metabolism, Vol 20, Iss, Pp 38-50 (2019)
Molecular Metabolism

Objective Sympathetic nervous system and immune cell interactions play key roles in the regulation of metabolism. For example, recent convergent studies have shown that macrophages regulate obesity through brown adipose tissue (BAT) activation and be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04e71d9135666658767fc8c752df935
https://eprints.gla.ac.uk/174996/1/174996.pdf

Neuronatin regulates pancreatic β cell insulin content and secretion.

Autor: Millership SJ; MRC London Institute of Medical Sciences, London, United Kingdom.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom., Da Silva Xavier G; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, United Kingdom., Choudhury AI; MRC London Institute of Medical Sciences, London, United Kingdom., Bertazzo S; Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom., Chabosseau P; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, United Kingdom., Pedroni SM; MRC London Institute of Medical Sciences, London, United Kingdom.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom., Irvine EE; MRC London Institute of Medical Sciences, London, United Kingdom., Montoya A; MRC London Institute of Medical Sciences, London, United Kingdom., Faull P; MRC London Institute of Medical Sciences, London, United Kingdom., Taylor WR; Computational Cell and Molecular Biology Laboratory, Francis Crick Institute, London, United Kingdom., Kerr-Conte J; European Genomic Institute for Diabetes, UMR 1190 Translational Research for Diabetes, INSERM, CHU Lille, University of Lille, Lille, France., Pattou F; European Genomic Institute for Diabetes, UMR 1190 Translational Research for Diabetes, INSERM, CHU Lille, University of Lille, Lille, France., Ferrer J; Beta Cell Genome Regulation Laboratory, Department of Medicine, Imperial College London, London, United Kingdom., Christian M; Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College London, London, United Kingdom., John RM; School of Biosciences, Cardiff University, Cardiff, United Kingdom., Latreille M; MRC London Institute of Medical Sciences, London, United Kingdom., Liu M; Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China., Rutter GA; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, United Kingdom., Scott J; National Heart and Lung Institute, Department of Medicine, Imperial College London, London, United Kingdom., Withers DJ; MRC London Institute of Medical Sciences, London, United Kingdom.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2018 Aug 01; Vol. 128 (8), pp. 3369-3381. Date of Electronic Publication: 2018 Jul 09.