Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Pedro de Sena Murteira, Pinheiro"'
Autor:
Lucas Silva Franco, Bárbara da Silva Mascarenhas de Jesus, Pedro de Sena Murteira Pinheiro, Carlos Alberto Manssour Fraga
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 742 (2024)
This work examines the current landscape of drug discovery and development, with a particular focus on the chemical and pharmacological spaces. It emphasizes the importance of understanding these spaces to anticipate future trends in drug discovery.
Externí odkaz:
https://doaj.org/article/703dc88bbcd0466e871da476c9008eff
Publikováno v:
Pharmaceuticals, Vol 16, Iss 8, p 1157 (2023)
One of the key scientific aspects of small-molecule drug discovery and development is the analysis of the relationship between its chemical structure and biological activity. Understanding the effects that lead to significant changes in biological ac
Externí odkaz:
https://doaj.org/article/2c04062d0231415497e0025725ccaaec
Autor:
Thayssa Tavares da Silva Cunha, Rafaela Ribeiro Silva, Daniel Alencar Rodrigues, Pedro de Sena Murteira Pinheiro, Thales Kronenberger, Carlos Maurício R. Sant’Anna, François Noël, Carlos Alberto Manssour Fraga
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1112 (2022)
Most neurodegenerative diseases are multifactorial, and the discovery of several molecular mechanisms related to their pathogenesis is constantly advancing. Dopamine and dopaminergic receptor subtypes are involved in the pathophysiology of several ne
Externí odkaz:
https://doaj.org/article/13ab0bb4c89448e6a0ffe44b9807756c
Autor:
Jéssica de Siqueira Guedes, Teiliane Rodrigues Carneiro, Pedro de Sena Murteira Pinheiro, Carlos Alberto Manssour Fraga, Carlos Mauricio R. Sant′Anna, Eliezer J. Barreiro, Lídia Moreira Lima
Publikováno v:
ACS Omega. 7:38752-38765
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::379577c4b5a866123e17bc4a39d5b4d0
https://doi.org/10.1021/acsomega.2c04368
https://doi.org/10.1021/acsomega.2c04368
Publikováno v:
ChemMedChem. 16(3)
The discovery of histone deacetylase (HDAC) inhibitors is a hot topic in the medicinal chemistry community regarding cancer research. This is related primarily to two factors: success in the clinic, e. g., the four FDA-approved HDAC inhibitors, and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907d5534bcbe1720e7d2d851a08245bf
https://pubmed.ncbi.nlm.nih.gov/33049098
https://pubmed.ncbi.nlm.nih.gov/33049098
Autor:
Elisa Uliassi, Flaminia Di Pietri, Ondrej Soukup, Manuela Bartolini, Claudia Albertini, Anna Tramarin, Lenka Pulkrabkova, Maria Laura Bolognesi, Sabrina Petralla, Rosaria Carmela Perone, Nicola Rizzardi, Romana Fato, Pedro de Sena Murteira Pinheiro
Publikováno v:
ChemMedChem. 16:187-198
Thanks to the widespread use and safety profile of donepezil (1) in the treatment of Alzheimer's disease (AD), one of the most widely adopted multi-target-directed ligand (MTDL) design strategies is to modify its molecular structure by linking a seco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1485fc5d25dca0b7c46d0c7398c7b08
https://doi.org/10.1002/cmdc.202000484
https://doi.org/10.1002/cmdc.202000484
Autor:
Maria Laura Bolognesi, Fernanda S. Sagrillo, Carlos A. M. Fraga, Daniel Alencar Rodrigues, Pedro de Sena Murteira Pinheiro
Publikováno v:
Medicinal Research Reviews. 40:2177-2211
Despite the applicability of histone deacetylase inhibitors (HDACis) for cancer treatment, several works in the literature have shown that these inhibitors can be used in several other diseases, such as neurodegenerative diseases (NDs). This review b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8069efbd69d327dacaab9e321d6482a5
https://doi.org/10.1002/med.21701
https://doi.org/10.1002/med.21701
Autor:
Marina Amaral Alves, Carlos A. M. Fraga, Patricia Dias Fernandes, Pedro de Sena Murteira Pinheiro, Carlos Mauricio R. Sant'Anna, Fernanda S. Sagrillo, Daniel Alencar Rodrigues, Sreekanth Thota, Fabiana Sélos Guerra, Lorrane S. Chaves
Publikováno v:
ChemMedChem. 15:539-551
Targeting histone deacetylases (HDACs) and phosphatidylinositol 3-kinases (PI3Ks) is a very promising approach for cancer treatment. This manuscript describes the design, synthesis, in vitro pharmacological profile, and molecular modeling of a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaaf213aecc07520225239a0f628f6d3
https://doi.org/10.1002/cmdc.201900716
https://doi.org/10.1002/cmdc.201900716
Autor:
Luzineide W. Tinoco, Pedro de Sena Murteira Pinheiro, Carlos A. M. Fraga, Carlos Mauricio R. Sant'Anna, Marina Amaral Alves, Alviclér Magalhães, Fernanda S. Sagrillo, Maria Clara R. Freitas, Sreekanth Thota, Daniel Alencar Rodrigues
Publikováno v:
New Journal of Chemistry. 44:10994-11005
Conformational stabilization mediated by hydrogen bonds can play an important role in the drug-target recognition process. Non-classical hydrogen bonding is receiving great attention, where C–H⋯Y hydrogen bonds are found in some biological system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e72464bfdae76ac7b927eaee1d27dcdb
https://doi.org/10.1039/d0nj01598a
https://doi.org/10.1039/d0nj01598a
Autor:
Carlos A. M. Fraga, Sreekanth Thota, Rodolfo C. Maia, Daniel Alencar Rodrigues, Pedro de Sena Murteira Pinheiro
Publikováno v:
Current Topics in Medicinal Chemistry. 19:1712-1733
During the early preclinical phase, from hit identification and optimization to a lead compound, several medicinal chemistry strategies can be used to improve potency and/or selectivity. The conformational restriction is one of these approaches. It c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c87ac74ac1b861d263514db5e4bd1c
https://doi.org/10.2174/1568026619666190712205025
https://doi.org/10.2174/1568026619666190712205025