Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Pedro Veliça"'
Autor:
David Bargiela, Pedro P. Cunha, Pedro Veliça, Lena C. M. Krause, Madara Brice, Laura Barbieri, Milos Gojkovic, Iosifina P. Foskolou, Helene Rundqvist, Randall S. Johnson
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cells must adapt to variations in tissue microenvironments; these adaptations include the degree of oxygen availability. The hypoxia-inducible factor (HIF) transcription factors control much of this adaptation, and thus regulate many aspects of T c
Externí odkaz:
https://doaj.org/article/d703e346bf7c41fdb678fe61ec28ff79
Autor:
Laura Barbieri, Pedro Veliça, Paulo A. Gameiro, Pedro P. Cunha, Iosifina P. Foskolou, Eric Rullman, David Bargiela, Randall S. Johnson, Helene Rundqvist
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionCD8+ T cells infiltrate virtually every tissue to find and destroy infected or mutated cells. They often traverse varying oxygen levels and nutrient-deprived microenvironments. High glycolytic activity in local tissues can result in signi
Externí odkaz:
https://doaj.org/article/19986cb6845141b5b562fb124f546668
Autor:
David Bargiela, Pedro P. Cunha, Pedro Veliça, Iosifina P. Foskolou, Laura Barbieri, Helene Rundqvist, Randall S. Johnson
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Targeting T cell metabolism is an established method of immunomodulation. Following activation, T cells engage distinct metabolic programs leading to the uptake and processing of nutrients that determine cell proliferation and differentiation. Redire
Externí odkaz:
https://doaj.org/article/668d9ea290db4d1cbceb843d033cf4c2
Autor:
Milos Gojkovic, Pedro P. Cunha, Gabriella S. Darmasaputra, Laura Barbieri, Helene Rundqvist, Pedro Veliça, Randall S. Johnson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Myeloid cell interactions with cells of the adaptive immune system are an essential aspect of immunity. A key aspect of that interrelationship is its modulation by the microenvironment. Oxygen is known to influence myelosuppression of T cell activati
Externí odkaz:
https://doaj.org/article/32ba1e879f97419cb6394ac9fbdd1b75
Autor:
Helene Rundqvist, Pedro Veliça, Laura Barbieri, Paulo A Gameiro, David Bargiela, Milos Gojkovic, Sara Mijwel, Stefan Markus Reitzner, David Wulliman, Emil Ahlstedt, Jernej Ule, Arne Östman, Randall S Johnson
Publikováno v:
eLife, Vol 9 (2020)
Exercise has a wide range of systemic effects. In animal models, repeated exertion reduces malignant tumor progression, and clinically, exercise can improve outcome for cancer patients. The etiology of the effects of exercise on tumor progression are
Externí odkaz:
https://doaj.org/article/d0d5122c3c474deba42ac6eb9326aaa1
Autor:
Angelika Holler, Mathias Zech, Sara Ghorashian, Rebecca Pike, Alastair Hotblack, Pedro Veliça, Shao-An Xue, Ronjon Chakraverty, Emma C. Morris, Hans J. Stauss
Publikováno v:
Haematologica, Vol 101, Iss 4 (2016)
Due to the lack of specificity for tumor antigens, allogeneic T-cell therapy is associated with graft-versus-host disease. Enhancing the anti-tumor specificity while reducing the graft-versus-host disease risk of allogeneic T cells has remained a res
Externí odkaz:
https://doaj.org/article/832853b6cf9444438aff1b61e124f0a5
Autor:
Pedro P. Cunha, Eleanor Minogue, Lena C. M. Krause, Rita M. Hess, David Bargiela, Brennan J. Wadsworth, Laura Barbieri, Carolin Brombach, Iosifina P. Foskolou, Ivan Bogeski, Pedro Veliça, Randall S. Johnson
Publikováno v:
eLife. 12
SummaryOxygenation levels are a determinative factor in T cell function. Here we describe that the oxygen tensions sensed by T cells at the moment of activation act to persistently modulate both differentiation and function. We found that in a protoc
Autor:
Randall S. Johnson, Pedro Veliça, Cristina M. Branco, Iosifina Foskolou, Sandra Pietsch, Emilia Marklund, Milos Gojkovic, Carolin Brombach, Laura Barbieri, Lena C.M. Krause, Eleanor Minogue, David Bargiela, Pedro P. Cunha
Supplementary Figures S1-S6, Supplementary Tables S1 and S3, and uncropped western blot images.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2865bcf6a3ad5a675e0d623f83a7a777
https://doi.org/10.1158/2326-6066.22546092.v1
https://doi.org/10.1158/2326-6066.22546092.v1
Autor:
Randall S. Johnson, Pedro Veliça, Cristina M. Branco, Iosifina Foskolou, Sandra Pietsch, Emilia Marklund, Milos Gojkovic, Carolin Brombach, Laura Barbieri, Lena C.M. Krause, Eleanor Minogue, David Bargiela, Pedro P. Cunha
Nitric oxide (NO) is a signaling molecule produced by NO synthases (NOS1–3) to control processes such as neurotransmission, vascular permeability, and immune function. Although myeloid cell–derived NO has been shown to suppress T-cell responses,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d0e287a4e9d71e4291efb0729bef0a
https://doi.org/10.1158/2326-6066.c.6551094
https://doi.org/10.1158/2326-6066.c.6551094
Autor:
Randall S. Johnson, Helene Rundqvist, Milos Gojkovic, David Bargiela, Iosifina Petrina Foskolou, Nikola Vojnovic, Pedro P. Cunha, Pedro Veliça
Adoptive transfer of antitumor cytotoxic T cells is an emerging form of cancer immunotherapy. A key challenge to expanding the utility of adoptive cell therapies is how to enhance the survival and function of the transferred T cells. Immune-cell surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8f3a6a60d0f17cd0e37ce847caadd7
https://doi.org/10.1158/2326-6066.c.6550212.v1
https://doi.org/10.1158/2326-6066.c.6550212.v1