Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Pedro Vallecillo-García"'
Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation
Autor:
Uirá Souto Melo, Jerome Jatzlau, Cesar A. Prada-Medina, Elisabetta Flex, Sunhild Hartmann, Salaheddine Ali, Robert Schöpflin, Laura Bernardini, Andrea Ciolfi, M-Hossein Moeinzadeh, Marius-Konstantin Klever, Aybuge Altay, Pedro Vallecillo-García, Giovanna Carpentieri, Massimo Delledonne, Melanie-Jasmin Ort, Marko Schwestka, Giovanni Battista Ferrero, Marco Tartaglia, Alfredo Brusco, Manfred Gossen, Dirk Strunk, Sven Geißler, Stefan Mundlos, Sigmar Stricker, Petra Knaus, Elisa Giorgio, Malte Spielmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Heterotopic ossification is a disorder caused by abnormal mineralization of soft tissues in which signaling pathways such as BMP, TGFβ and WNT are known key players in driving ectopic bone formation. Identifying novel genes and pathways rel
Externí odkaz:
https://doaj.org/article/4848e7ed684e495f8ace27fcba8b8f77
Autor:
Georgios Kotsaris, Taimoor H. Qazi, Christian H. Bucher, Hafsa Zahid, Sophie Pöhle-Kronawitter, Vladimir Ugorets, William Jarassier, Stefan Börno, Bernd Timmermann, Claudia Giesecke-Thiel, Aris N. Economides, Fabien Le Grand, Pedro Vallecillo-García, Petra Knaus, Sven Geissler, Sigmar Stricker
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-16 (2023)
Abstract Skeletal muscle regeneration requires the coordinated interplay of diverse tissue-resident- and infiltrating cells. Fibro-adipogenic progenitors (FAPs) are an interstitial cell population that provides a beneficial microenvironment for muscl
Externí odkaz:
https://doaj.org/article/ad0ff3860df043db9035284978595edb
Autor:
Uirá Souto Melo, Jerome Jatzlau, Cesar A. Prada-Medina, Elisabetta Flex, Sunhild Hartmann, Salaheddine Ali, Robert Schöpflin, Laura Bernardini, Andrea Ciolfi, M-Hossein Moeinzadeh, Marius-Konstantin Klever, Aybuge Altay, Pedro Vallecillo-García, Giovanna Carpentieri, Massimo Delledonne, Melanie-Jasmin Ort, Marko Schwestka, Giovanni Battista Ferrero, Marco Tartaglia, Alfredo Brusco, Manfred Gossen, Dirk Strunk, Sven Geißler, Stefan Mundlos, Sigmar Stricker, Petra Knaus, Elisa Giorgio, Malte Spielmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/81fd3b11d7934ebcb13c04401024e74d
Autor:
Jürgen Stumm, Pedro Vallecillo-García, Sophie Vom Hofe-Schneider, David Ollitrault, Heinrich Schrewe, Aris N. Economides, Giovanna Marazzi, David A. Sassoon, Sigmar Stricker
Publikováno v:
Stem Cell Research, Vol 32, Iss , Pp 8-16 (2018)
Fibro-adipogenic progenitors (FAPs) are resident mesenchymal progenitors in adult skeletal muscle that support muscle repair, but also give rise to fibrous and adipose infiltration in response to disease and chronic injury. FAPs are identified using
Externí odkaz:
https://doaj.org/article/998eb6efcebd4550a4742b5099f18bf3
Autor:
Glenda Evangelina Comai, Markéta Tesařová, Valérie Dupé, Muriel Rhinn, Pedro Vallecillo-García, Fabio da Silva, Betty Feret, Katherine Exelby, Pascal Dollé, Leif Carlsson, Brian Pryce, François Spitz, Sigmar Stricker, Tomáš Zikmund, Jozef Kaiser, James Briscoe, Andreas Schedl, Norbert B Ghyselinck, Ronen Schweitzer, Shahragim Tajbakhsh
Publikováno v:
PLoS Biology, Vol 18, Iss 11, p e3000902 (2020)
Coordinated development of muscles, tendons, and their attachment sites ensures emergence of functional musculoskeletal units that are adapted to diverse anatomical demands among different species. How these different tissues are patterned and functi
Externí odkaz:
https://doaj.org/article/7accca2f58eb48ea8737767ca272038f
Autor:
Pedro Vallecillo-García, Mickael Orgeur, Sophie vom Hofe-Schneider, Jürgen Stumm, Verena Kappert, Daniel M. Ibrahim, Stefan T. Börno, Shinichiro Hayashi, Frédéric Relaix, Katrin Hildebrandt, Gerhard Sengle, Manuel Koch, Bernd Timmermann, Giovanna Marazzi, David A. Sassoon, Delphine Duprez, Sigmar Stricker
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Fibro-adipogenic progenitors (FAPs) form part of interstitial muscle connective tissue (MCT) in adults but the origin of this non-myogenic lineage is unclear. Here, the authors show that Odd skipped related 1 (Osr1) in mice marks embryonic MCT, givin
Externí odkaz:
https://doaj.org/article/1e034f7aaeb14e40b5bb3d020e082645
Autor:
Pedro Vallecillo-García, Mickael Orgeur, Glenda Comai, Sophie Poehle-Kronnawitter, Cornelius Fischer, Marleen Gloger, Camille E. Dumas, Claudia Giesecke-Thiel, Sascha Sauer, Shahragim Tajbakhsh, Uta E. Höpken, Sigmar Stricker
Publikováno v:
Immunity.
Autor:
Georgios Kotsaris, Taimoor H. Qazi, Christian H. Bucher, Sophie Pöhle-Kronawitter, Vladimir Ugorets, William Jarassier, Stefan Börno, Bernd Timmermann, Claudia Giesecke-Thiel, Pedro Vallecillo-García, Aris N. Economides, Fabien Le Grand, Petra Knaus, Sven Geissler, Sigmar Stricker
Skeletal muscle regeneration requires the coordinated interplay of diverse tissue-resident- and infiltrating cells. Fibro-adipogenic progenitors (FAPs) are an interstitial cell population that provides a beneficial microenvironment for muscle stem ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6c8f0dae093a4e80890eaf661398d19
https://doi.org/10.1101/2022.07.04.498663
https://doi.org/10.1101/2022.07.04.498663
Autor:
Pedro Vallecillo García, Mickael Orgeur, Glenda Comai, Sophie Pöhle-Kronawitter, Cornelius Fischer, Marleen Gloger, Claudia Giesecke-Thiel, Sascha Sauer, Shahragim Tajbakhsh, Uta E. Höpken, Sigmar Stricker
Publikováno v:
SSRN Electronic Journal.
Autor:
Sigmar Stricker, Pedro Vallecillo-García, Daniel M. Ibrahim, Stefan Mundlos, Katerina Kraft, Jürgen Stumm, Pia Kuss
Publikováno v:
Developmental Biology. (1):83-93
The morphology of bones is genetically determined, but the molecular mechanisms that control shape, size and the overall gestalt of bones remain unclear. We previously showed that metacarpals in the synpolydactyly homolog (spdh) mouse, which carries