Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Pedro Rodriguez-Cutillas"'
Autor:
Jenna Scotcher, Oleksandra Prysyazhna, Andrii Boguslavskyi, Kornel Kistamas, Natasha Hadgraft, Eva D. Martin, Jenny Worthington, Olena Rudyk, Pedro Rodriguez Cutillas, Friederike Cuello, Michael J. Shattock, Michael S. Marber, Maria R. Conte, Adam Greenstein, David J. Greensmith, Luigi Venetucci, John F. Timms, Philip Eaton
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The stroke volume of the heart increases in response to an increase in the blood volume filling the heart. Here the authors reveal that this coordinated process is mediated in part by oxidative activation of the protein kinase G Iα, which phosphoryl
Externí odkaz:
https://doaj.org/article/03ace94ba067478fa8463d2ab1ace41b
Autor:
Nosheen Akhtar, Muhammad Waleed Baig, Ihsan-ul Haq, Vinothini Rajeeve, Pedro Rodriguez Cutillas
Publikováno v:
Biomedicines, Vol 8, Iss 9, p 333 (2020)
Acute myeloid leukemia (AML) is an aggressive disease and, despite advances, its treatment remains challenging. Therefore, it remains important to identify new agents for the management of this disease. Withanolides, a group of steroidal lactones fou
Externí odkaz:
https://doaj.org/article/28c88198bf9c450e8c8afd8583866e10
Publikováno v:
Bioinformatics. 39
Motivation Pathway inference methods are important for annotating the genome, for providing insights into the mechanisms of biochemical processes and allow the discovery of signalling members and potential new drug targets. Here, we tested the hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7605f360d76d5c7ab0b3fa048fa61890
https://doi.org/10.1093/bioinformatics/btac769
https://doi.org/10.1093/bioinformatics/btac769
Autor:
Kevin Rouault-Pierre, Federico Pedicona, MARUAN HIJAZI VEGA, Pedro Casado, John Gribben, Pedro Rodriguez Cutillas
Publikováno v:
Science signaling. 15(730)
Most tumor types either fail to respond or become resistant to kinase inhibitors, often because of compensatory prosurvival pathways in the cancer cell’s broader signaling circuitry. Here, we found that intrinsic resistance to kinase inhibitors in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca22c3910ebbc81d3368c9c64ff373d
https://pubmed.ncbi.nlm.nih.gov/35439022
https://pubmed.ncbi.nlm.nih.gov/35439022
Autor:
Luis Veiga Nobre, Celia Colomina Basanta, Salvatore Federico Pedicona, Arran David Dokal, Andrea Arruda, Ryan Smith, Calum Greenhalgh, Francesca Patella, Pedro Maria Casado-Izquierdo, Bela Wrench, Jane Theaker, Andrew Thompson, Mark D. Minden, John G. Gribben, David James Britton, Pedro Rodriguez Cutillas
Publikováno v:
Molecular Cancer Therapeutics. 20:LBA013-LBA013
Background: Midostaurin (mido) is approved for treatment of FLT3 mutant-positive (FLT3+) acute myeloid leukemia (AML). However, FLT3 mutation is not the only determinant of mido sensitivity. Here we report phosphoprotein signatures which predict resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8873e44e70a3ed3af8412b73d39fd598
https://doi.org/10.1158/1535-7163.targ-21-lba013
https://doi.org/10.1158/1535-7163.targ-21-lba013
Autor:
Giulia Fabbri, Jordi Bertran-Alamillo, David Britton, Shona Ellison, Jon Travers, Urszula M. Polanska, Ana Giménez-Capitán, Vinothini Rajeeve, Jelena Urosevic, Pedro Rodriguez-Cutillas, Arran Dokal, Miguel Angel Molina-Vila, Maruan Higazi-Vega, Edmund Wilkes, J. Elizabeth Pease, Ruth Osuntola, Calum Greenhalgh, Hilary J. Lewis
Publikováno v:
Cancer Research. 81:1107-1107
Background: NSCLC cells carrying EGFR mutations can gain resistance to cognate TKIs through amplification of Chr22q11.2 (Chr22amp), a chromosome segment containing CRKL. This also specifically associates with exquisite sensitivity to inhibitors of Au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77e7edbbc584daa218d7b72ca1f5ce17
https://doi.org/10.1158/1538-7445.am2021-1107
https://doi.org/10.1158/1538-7445.am2021-1107
Publikováno v:
Clinical Chemistry. 53:375-376
The “urinary peptidome” promises to be a resource at least as dynamic and informative as the “urinary proteome”. Given that neither approach has so far given up many clinical pearls, this may not be saying much. But one likely pathway for uri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4a9d96f6f9f598aae0021f5f297dc0e
https://doi.org/10.1373/clinchem.2006.084038
https://doi.org/10.1373/clinchem.2006.084038