Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Pedro Rebelo"'
Publikováno v:
Saúde & Tecnologia, Iss 30 (2024)
Introdução – A incontinência urinária (IU) ou perda involuntária de urina é uma condição de saúde frequente e preocupante, que pode ser subdividida em três tipos comuns: IU de esforço, de urgência ou mista. Objetivos – Identificar a p
Externí odkaz:
https://doaj.org/article/a1415626555c4ea5abcc9dce8af92040
Publikováno v:
Saúde & Tecnologia, Iss 29 (2023)
Introdução e Objetivos – Aproximadamente 80% dos sobreviventes de acidente vascular cerebral (AVC) apresentam défices de equilíbrio e até 58% apresentam risco de queda no primeiro ano após AVC. Uma das intervenções que tem sido utilizada pa
Externí odkaz:
https://doaj.org/article/1ea2e17e686246e99dc21a2fd689d3db
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102605- (2023)
Summary: Dynamic macromolecular complexes containing a large number of components are often difficult to study using conventional approaches, such as immunoblotting. Here, we present a protocol for the analysis of macromolecular complexes in near-nat
Externí odkaz:
https://doaj.org/article/f5debe849ae149ca99ef702e498a5d93
Autor:
Lindsey Van Haute, Emily O’Connor, Héctor Díaz-Maldonado, Benjamin Munro, Kiran Polavarapu, Daniella H. Hock, Gautham Arunachal, Alkyoni Athanasiou-Fragkouli, Mainak Bardhan, Magalie Barth, Dominique Bonneau, Nicola Brunetti-Pierri, Gerarda Cappuccio, Nikeisha J. Caruana, Natalia Dominik, Himanshu Goel, Guy Helman, Henry Houlden, Guy Lenaers, Karine Mention, David Murphy, Bevinahalli Nandeesh, Catarina Olimpio, Christopher A. Powell, Veeramani Preethish-Kumar, Vincent Procaccio, Rocio Rius, Pedro Rebelo-Guiomar, Cas Simons, Seena Vengalil, Maha S. Zaki, Alban Ziegler, David R. Thorburn, David A. Stroud, Reza Maroofian, John Christodoulou, Claes Gustafsson, Atchayaram Nalini, Hanns Lochmüller, Michal Minczuk, Rita Horvath
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Van Haute et al describe autosomal recessive TEFM variants that impair mitochondrial transcription elongation and reduce the levels of promoter distal mitochondrial RNA transcripts, leading to heterogeneous mitochondrial diseases with a treatable neu
Externí odkaz:
https://doaj.org/article/cd5cc9ecdd2c4821a6750da1e26f46ce
Autor:
Pedro Rebelo-Guiomar, Simone Pellegrino, Kyle C. Dent, Aldema Sas-Chen, Leonor Miller-Fleming, Caterina Garone, Lindsey Van Haute, Jack F. Rogan, Adam Dinan, Andrew E. Firth, Byron Andrews, Alexander J. Whitworth, Schraga Schwartz, Alan J. Warren, Michal Minczuk
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Rebelo-Guiomar et al. unveil late stage assembly intermediates of the human mitochondrial ribosome by inactivating the methyltransferase MRM2 in cells. Absence of MRM2 impairs organismal homeostasis, while its catalytic activity is dispensable for mi
Externí odkaz:
https://doaj.org/article/b26a6648dba14e5181a35583967acaa7
Publikováno v:
Saúde & Tecnologia, Iss 11 (2022)
Introdução – O futsal é um desporto exigente, pelo que a aplicação de bandas de kinesio tape surge como uma vertente de intervenção a considerar. Objetivos – Analisar o efeito do kinesio tape na ativação e amplitude muscular do longo per
Externí odkaz:
https://doaj.org/article/9ce76d22335640b49408b639def91cff
Autor:
Matthew Baxter, Maria Voronkov, Toryn Poolman, Gina Galli, Christian Pinali, Laurence Goosey, Abigail Knight, Karolina Krakowiak, Robert Maidstone, Mudassar Iqbal, Min Zi, Sukhpal Prehar, Elizabeth J Cartwright, Julie Gibbs, Laura C Matthews, Antony D Adamson, Neil E Humphreys, Pedro Rebelo-Guiomar, Michal Minczuk, David A Bechtold, Andrew Loudon, David Ray
Publikováno v:
eLife, Vol 9 (2020)
Efficient mitochondrial function is required in tissues with high energy demand such as the heart, and mitochondrial dysfunction is associated with cardiovascular disease. Expression of mitochondrial proteins is tightly regulated in response to inter
Externí odkaz:
https://doaj.org/article/c80495bec8114315bceead7ae22ca77e
Autor:
Viktoriya Peeva, Daniel Blei, Genevieve Trombly, Sarah Corsi, Maciej J. Szukszto, Pedro Rebelo-Guiomar, Payam A. Gammage, Alexei P. Kudin, Christian Becker, Janine Altmüller, Michal Minczuk, Gábor Zsurka, Wolfram S. Kunz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Damaged linearized mtDNA needs to be removed from the cell for mitochondrial genome stability. Here the authors shed light into the identity of the machinery responsible for rapidly degrading linearized DNA, implicating the role of mtDNA replication
Externí odkaz:
https://doaj.org/article/979579d067db4608bae2ab8f5bf93bd8
Publikováno v:
Saúde & Tecnologia, Vol 0, Iss 11, Pp 34-40 (2015)
Introduction – Futsal is a demanding sport, so the application of kinesio tape bands emerges as an intervention hypothesis to take in consideration. Objectives – To analyze kinesio tape effects on the muscular range and activation of the peroneal
Externí odkaz:
https://doaj.org/article/272b30140862465a83a8a14ea6fcbf35
Autor:
Sarah F Pearce, Joanna Rorbach, Lindsey Van Haute, Aaron R D’Souza, Pedro Rebelo-Guiomar, Christopher A Powell, Ian Brierley, Andrew E Firth, Michal Minczuk
Publikováno v:
eLife, Vol 6 (2017)
Human mitochondria contain a genome (mtDNA) that encodes essential subunits of the oxidative phosphorylation system. Expression of mtDNA entails multi-step maturation of precursor RNA. In other systems, the RNA life cycle involves surveillance mechan
Externí odkaz:
https://doaj.org/article/33fe4df6fee0477eae319afd1470c825