Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Pedro R. Urquilla"'
Autor:
Sherwyn Schwartz, Mark E. Williams, Carlos J. Arauz-Pacheco, Thomas B. Neff, Warren K. Bolton, Dongxia Li, Pedro R. Urquilla, Tyson Lee, K. Lea Sewell, Sharon G. Adler
Publikováno v:
Clinical Journal of the American Society of Nephrology. 5:1420-1428
Background and objectives: This report summarizes the first phase 1 trial treating patients with microalbuminuric diabetic kidney disease (DKD) using FG-3019, a human monoclonal antibody to connective tissue growth factor (CTGF). CTGF is critically i
Autor:
Robert Z. Orlowski, Suzanne Trudel, Andre Goy, Melissa Alsina, Pedro R. Urquilla, Christopher J. Molineaux, Keith Stewart, Marcy Vallone, Tina M. Woo, Owen A. O'Connor
Publikováno v:
Blood. 108:2430-2430
INTRODUCTION: PR-171 is a novel, irreversible proteasome inhibitor under investigation for the treatment of hematological malignancies. In preclinical studies, PR-171 was well tolerated in rats and monkeys when given daily × 5 (QDx5), every two week
Autor:
Pedro R. Urquilla
Publikováno v:
Journal of Vascular Research. 13:249-252
Publikováno v:
Journal of Vascular Research. 12:53-67
5-Hydroxytryptamine (5-HT), norepinephrine (NE), histamine (H) and potassium (K+) chloride induce dose-dependent changes in tension of the isolated middle cerebral artery of the goat. Vasopressin produces highly variable responses followed by tachyph
Autor:
Mark E. Wilson, Robert L. Robinson, Michael D. Taylor, David M. Smith, Pedro R. Urquilla, Michael A. Trush, Knox Van Dyke
Publikováno v:
Pharmacology. 15:377-391
The catecholamine and nucleotide content of chromaffin granules from bovine adrenal medulla was analyzed both qualitatively and quantitatively. Nucleotides were examined by separation on anion exchange high pressure liquid chromatography and ultravio
Publikováno v:
Stroke. 5(4)
Tyramine induces dose-dependent changes in tension of the isolated middle cerebral artery of the goat. Cocaine, phentolamine and reserpine reduce the sensitivity of the tissue to tyramine by factors of 2.8, 3.7 and 3.7, respectively. The norepinephri
Publikováno v:
European journal of pharmacology. 66(1)
Potassium ( 42 K) or chloride ( 36 Cl) efflux curves were determined in guinea-pig vas deferens from control, reserpine-treated animals (1 mg/kg/day i.p. for 5 days), and from animals whose vas deferens had been sympathetically denervated 1 week befo
Publikováno v:
Journal of Pharmacy and Pharmacology. 30:189-190
Autor:
David Smith, Fred A. Simpson, Chang W. Rhee, Hang J. Yoon, Richard B. Knapp, Jeanne M. Rushin, Hak S. Lee, Thara Srichomkuan, Pedro R. Urquilla
Publikováno v:
Anesthesia & Analgesia. 58:189
The cardiovascular effects of benzquinamide were evaluated in anesthetized dogs. Intravenous benzquinamide, 0.5 to 5 mg/kg, caused tachycardia, elevated blood norepinephrine levels, frequent ventricular arrhythmias, and brief hypotension. Ganglionic