Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Pedro R. Magalhães"'
Autor:
Beatriz Bueschbell, Pedro R. Magalhães, Carlos A.V. Barreto, Rita Melo, Anke C. Schiedel, Miguel Machuqueiro, Irina S. Moreira
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4336-4353 (2023)
G protein-coupled receptors (GPCRs) are known to dimerize, but the molecular and structural basis of GPCR dimers is not well understood. In this study, we developed a computational framework to generate models of symmetric and asymmetric GPCR dimers
Externí odkaz:
https://doaj.org/article/2c5100c6630647dcac9e0546876e59bc
Autor:
Enrico Cadoni, Pedro R. Magalhães, Rita M. Emídio, Eduarda Mendes, Jorge Vítor, Josué Carvalho, Carla Cruz, Bruno L. Victor, Alexandra Paulo
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 669 (2021)
G-quadruplex (G4)-interactive small molecules have a wide range of potential applications, not only as drugs, but also as sensors of quadruplex structures. The purpose of this work is the synthesis of analogues of the bis-methylquinolinium-pyridine-2
Externí odkaz:
https://doaj.org/article/5eb42be30c284b3bbf3d877d0f4347f1
Autor:
Pedro R. Magalhães, Miguel Machuqueiro, José G. Almeida, André Melo, M. Natália D. S. Cordeiro, Sandra Cabo Verde, Zeynep H. Gümüş, Irina S. Moreira, João D. G. Correia, Rita Melo
Publikováno v:
Biomolecules, Vol 9, Iss 11, p 706 (2019)
Human epidermal growth factor 2 (HER2) is a ligand-free tyrosine kinase receptor of the HER family that is overexpressed in some of the most aggressive tumours. Although it is known that HER2 dimerization involves a specific region of its extracellul
Externí odkaz:
https://doaj.org/article/9aa8e44dfb4c44048ac8eb1ae5b74525
Autor:
Carlos A.V. Barreto, Salete J. Baptista, Beatriz Bueschbell, Pedro R. Magalhães, António J. Preto, Agostinho Lemos, Nícia Rosário‐Ferreira, Anke C. Schiedel, Miguel Machuqueiro, Rita Melo, Irina S. Moreira
Publikováno v:
GPCRs as Therapeutic Targets. :109-179
Autor:
Pedro R. Magalhães, Pedro B. P. S. Reis, Diogo Vila-Viçosa, Miguel Machuqueiro, Bruno L. Victor
Publikováno v:
Journal of Chemical Information and Modeling. 62:3034-3042
Autor:
Pedro R, Magalhães, Pedro B P S, Reis, Diogo, Vila-Viçosa, Miguel, Machuqueiro, Bruno L, Victor
Publikováno v:
Journal of chemical information and modeling. 62(12)
Membrane pan-assay interference compounds (PAINS) are a class of molecules that interact nonspecifically with lipid bilayers and alter their physicochemical properties. An early identification of these compounds avoids chasing false leads and the nee
Autor:
Pedro R. Magalhães, Pedro B. P. S. Reis, Diogo Vila-Viçosa, Miguel Machuqueiro, Bruno L. Victor
Membrane Pan-Assay INterference compoundS (PAINS) are a class of molecules that interact non-specifically with lipid bilayers and alter their physicochemical properties. An early identification of these compounds avoids chasing false leads and the ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c364513541e43802dda040304f656d9f
https://doi.org/10.26434/chemrxiv-2021-t036h
https://doi.org/10.26434/chemrxiv-2021-t036h
Autor:
Pedro R, Magalhães, Pedro B P S, Reis, Diogo, Vila-Viçosa, Miguel, Machuqueiro, Bruno L, Victor
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2315
Pan-assay interference compounds (PAINS) are promiscuous molecules with multiple behaviors that interfere with assay readouts. Membrane PAINS are a subset of these compounds that influence the function of membrane proteins by nonspecifically perturbi
Autor:
Alexandra Paulo, Bruno L. Victor, Enrico Cadoni, Carla Cruz, Josué Carvalho, Eduarda Mendes, Pedro R. Magalhães, Jorge M. B. Vítor, Rita M. Emídio
Publikováno v:
Pharmaceuticals
Volume 14
Issue 7
Pharmaceuticals, Vol 14, Iss 669, p 669 (2021)
Volume 14
Issue 7
Pharmaceuticals, Vol 14, Iss 669, p 669 (2021)
G-quadruplex (G4)-interactive small molecules have a wide range of potential applications, not only as drugs, but also as sensors of quadruplex structures. The purpose of this work is the synthesis of analogues of the bis-methylquinolinium-pyridine-2
Autor:
Enrico Cadoni, Jorge M. B. Vítor, Pedro R. Magalhães, Eduarda Mendes, Josué Carvalho, Bruno L. Victor, Carla Cruz, Rita M. Emídio, Alexandra Paulo
Quadruplex-interactive small molecules have a wide potential application, not only as drugs but also as sensors of quadruplexes structures. The purpose of this work is the synthesis of analogues of the bis-methylquinolinium-pyridine-2,6-dicarboxamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3d567b93e08c5f79db36ebadd606c1
https://doi.org/10.20944/preprints202105.0784.v1
https://doi.org/10.20944/preprints202105.0784.v1