Zobrazeno 1 - 10
of 383
pro vyhledávání: '"Pedro R, Cutillas"'
Autor:
Sarah E. Conduit, Wayne Pearce, Amandeep Bhamra, Benoit Bilanges, Laura Bozal-Basterra, Lazaros C. Foukas, Mathias Cobbaut, Sandra D. Castillo, Mohammad Amin Danesh, Mahreen Adil, Arkaitz Carracedo, Mariona Graupera, Neil Q. McDonald, Peter J. Parker, Pedro R. Cutillas, Silvia Surinova, Bart Vanhaesebroeck
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Primary cilia are antenna-like organelles which sense extracellular cues and act as signalling hubs. Cilia dysfunction causes a heterogeneous group of disorders known as ciliopathy syndromes affecting most organs. Cilia disassembly, the proc
Externí odkaz:
https://doaj.org/article/73d0a1177d1d4ad6bd109cda96644ef1
Autor:
Weronika E. Borek, Luis Nobre, S. Federico Pedicona, Amy E. Campbell, Josie A. Christopher, Nazrath Nawaz, David N. Perkins, Pedro Moreno-Cardoso, Janet Kelsall, Harriet R. Ferguson, Bela Patel, Paolo Gallipoli, Andrea Arruda, Alex J. Ambinder, Andrew Thompson, Andrew Williamson, Gabriel Ghiaur, Mark D. Minden, John G. Gribben, David J. Britton, Pedro R. Cutillas, Arran D. Dokal
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105316- (2024)
Summary: Background: Acute myeloid leukaemia (AML) is a bone marrow malignancy with poor prognosis. One of several treatments for AML is midostaurin combined with intensive chemotherapy (MIC), currently approved for FLT3 mutation-positive (FLT3-MP) A
Externí odkaz:
https://doaj.org/article/c1ed1c39383540cb899802e9a5af0c25
Autor:
Pedro Casado, Ana Rio-Machin, Juho J. Miettinen, Findlay Bewicke-Copley, Kevin Rouault-Pierre, Szilvia Krizsan, Alun Parsons, Vinothini Rajeeve, Farideh Miraki-Moud, David C. Taussig, Csaba Bödör, John Gribben, Caroline Heckman, Jude Fitzgibbon, Pedro R. Cutillas
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Acute myeloid leukaemia (AML) patients harbouring certain chromosome abnormalities have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact. To understand the molecular lands
Externí odkaz:
https://doaj.org/article/5e487f8d5d7f4d8e866dad9751eee848
Autor:
Arran Dokal, Weronika E. Borek, Luis Nobre, Salvatore Federico Pedicona, Bela Wrench, Paolo Gallipoli, Andrea Arruda, Amy E. Campbell, Nazrath Nawaz, Harriet R. Ferguson, David N. Perkins, Pedro Moreno-Cardoso, Andrew Thompson, Andrew J.K. Williamson, Mark D. Minden, John G. Gribben, David J. Britton, Pedro R. Cutillas
Publikováno v:
HemaSphere, Vol 7, p e3920765 (2023)
Externí odkaz:
https://doaj.org/article/9587d3fdbfdb464ab33fdd2f65eb362d
Autor:
Celia De Los Angeles Colomina Basanta, Marya Bazzi, Maruan Hijazi, Conrad Bessant, Pedro R Cutillas
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 6, p e1010459 (2023)
Phosphoproteomics allows one to measure the activity of kinases that drive the fluxes of signal transduction pathways involved in biological processes such as immune function, senescence and cell growth. However, deriving knowledge of signalling netw
Externí odkaz:
https://doaj.org/article/6ea4b07a280243fe9d1d668fc29d361f
Publikováno v:
FEBS Open Bio, Vol 12, Iss 7, Pp 1388-1405 (2022)
Neuroblastoma (NB) is a heterogeneous cancer of the sympathetic nervous system, which accounts for 7–10% of paediatric malignancies worldwide. Due to the lack of targetable molecular aberrations in NB, most treatment options remain relatively nonsp
Externí odkaz:
https://doaj.org/article/e1ede00f8a904573ae2317a29585496c
Autor:
William Grey, Samantha Atkinson, Beatrice Rix, Pedro Casado, Linda Ariza-McNaughton, Cathy Hawley, Miriam L. Sopoena, Katherine S. Bridge, David Kent, Pedro R. Cutillas, Dominique Bonnet
Publikováno v:
HemaSphere, Vol 7, Iss 3, p e853 (2023)
Long-term hematopoietic stem cells are rare, highly quiescent stem cells of the hematopoietic system with life-long self-renewal potential and the ability to transplant and reconstitute the entire hematopoietic system of conditioned recipients. Most
Externí odkaz:
https://doaj.org/article/4e0fa0757b774e4ca29813340f26d393
Autor:
Arlinda Dullovi, Meryem Ozgencil, Vinothini Rajvee, Wai Yiu Tse, Pedro R. Cutillas, Sarah A. Martin, Zuzana Hořejší
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106107- (2023)
Summary: The DNA-damage response is a complex signaling network that guards genomic integrity. The microtubule cytoskeleton is involved in the repair of DNA double-strand breaks; however, little is known about which cytoskeleton-related proteins are
Externí odkaz:
https://doaj.org/article/59f0d612b282420fb66d26bbfc917799
Autor:
Kathryn Davidson, Paul Grevitt, Maria F. Contreras-Gerenas, Katherine S. Bridge, Miguel Hermida, Kunal M. Shah, Faraz K. Mardakheh, Mark Stubbs, Rosemary Burke, Pedro Casado, Pedro R. Cutillas, Sarah A. Martin, Tyson V. Sharp
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Abstract An early event in lung oncogenesis is loss of the tumour suppressor gene LIMD1 (LIM domains containing 1); this encodes a scaffold protein, which suppresses tumorigenesis via a number of different mechanisms. Approximately 45% of non-small c
Externí odkaz:
https://doaj.org/article/006a5cc989ef440e83fa93a4ded65708
Autor:
Angelica Gualtieri, Nikolina Kyprianou, Louise C. Gregory, Maria Lillina Vignola, James G. Nicholson, Rachael Tan, Shin-ichi Inoue, Valeria Scagliotti, Pedro Casado, James Blackburn, Fernando Abollo-Jimenez, Eugenia Marinelli, Rachael E. J. Besser, Wolfgang Högler, I. Karen Temple, Justin H. Davies, Andrey Gagunashvili, Iain C.A.F. Robinson, Sally A. Camper, Shannon W. Davis, Pedro R. Cutillas, Evelien F. Gevers, Yoko Aoki, Mehul T. Dattani, Carles Gaston-Massuet
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Mutations in components of the MAP kinase pathway are associated with a group of syndromes known as RASopathies. Here, the authors identify gain-of-function mutations in BRAF in patients with RASopathies and congenital hypopituitarisms. This article
Externí odkaz:
https://doaj.org/article/e3eb9cf575fa459d8daff6264b919278