Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Pedro Olivares-Chauvet"'
Autor:
Nina Mitic, Anika Neuschulz, Bastiaan Spanjaard, Julia Schneider, Nora Fresmann, Klara Tereza Novoselc, Taraneh Strunk, Lisa Münster, Pedro Olivares-Chauvet, Jovica Ninkovic, Jan Philipp Junker
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 4, Pp 321-337 (2024)
Abstract Adult stem cells are important for tissue turnover and regeneration. However, in most adult systems it remains elusive how stem cells assume different functional states and support spatially patterned tissue architecture. Here, we dissected
Externí odkaz:
https://doaj.org/article/05349cd3ad13492f958e56557b17da7e
Autor:
Anika Neuschulz, Olga Bakina, Victor Badillo‐Lisakowski, Pedro Olivares‐Chauvet, Thomas Conrad, Michael Gotthardt, Helmut Kettenmann, Jan Philipp Junker
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 2, Pp 1-13 (2022)
Abstract Tissue dissociation, a crucial step in single‐cell sample preparation, can alter the transcriptional state of a sample through the intrinsic cellular stress response. Here we demonstrate a general approach for measuring transcriptional res
Externí odkaz:
https://doaj.org/article/082ccd7c192740a3a8f78db215e2cb8b
Autor:
George Pappas, Sebastian Howen Nesgaard Munk, Kenji Watanabe, Quentin Thomas, Zita Gál, Helena Hagner Gram, MyungHee Lee, Daniel Gómez-Cabello, Dimitris Christos Kanellis, Pedro Olivares-Chauvet, Dorthe Helena Larsen, Lea Haarup Gregersen, Apolinar Maya-Mendoza, Panagiotis Galanos, Jiri Bartek
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111979- (2023)
Summary: The role of MDC1 in the DNA damage response has been extensively studied; however, its impact on other cellular processes is not well understood. Here, we describe the role of MDC1 in transcription as a regulator of RNA polymerase II (RNAPII
Externí odkaz:
https://doaj.org/article/50019a16f1e04bee8a3f5e43aa9acc20
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108606- (2021)
Summary: Embryonic development seemingly proceeds with almost perfect precision. However, it is largely unknown how much underlying microscopic variability is compatible with normal development. Here, we quantify embryo-to-embryo variability in verte
Externí odkaz:
https://doaj.org/article/315bb72948a5452891e5532da22ed65f
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e27527 (2011)
The distribution of chromatin within the mammalian nucleus is constrained by its organization into chromosome territories (CTs). However, recent studies have suggested that promiscuous intra- and inter-chromosomal interactions play fundamental roles
Externí odkaz:
https://doaj.org/article/c11f9fddfdc4403a817b5d59cc238b9d
Publikováno v:
PLoS Genetics, Vol 6, Iss 4, p e1000900 (2010)
DNA synthesis must be performed with extreme precision to maintain genomic integrity. In mammalian cells, different genomic regions are replicated at defined times, perhaps to preserve epigenetic information and cell differentiation status. However,
Externí odkaz:
https://doaj.org/article/44693891f10e4ceb81242eb3a4e99613
Autor:
Anika Neuschulz, Olga Bakina, Victor Badillo‐Lisakowski, Pedro Olivares‐Chauvet, Thomas Conrad, Michael Gotthardt, Helmut Kettenmann, Jan Philipp Junker
Publikováno v:
Molecular Systems Biology. 19
Tissue dissociation, a crucial step in single-cell sample preparation, can alter the transcriptional state of a sample through the intrinsic cellular stress response. Here we demonstrate a general approach for measuring transcriptional response durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0776ef4d81d7ca0738526f481cd71673
https://doi.org/10.15252/msb.202211147
https://doi.org/10.15252/msb.202211147
Publikováno v:
Cell Reports
Cell Reports, Vol 34, Iss 2, Pp 108606-(2021)
Cell Reports, Vol 34, Iss 2, Pp 108606-(2021)
Summary Embryonic development seemingly proceeds with almost perfect precision. However, it is largely unknown how much underlying microscopic variability is compatible with normal development. Here, we quantify embryo-to-embryo variability in verteb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5140cd73e0c5c1dff63cce302da5dad0
http://edoc.mdc-berlin.de/19147/1/19147oa.pdf
http://edoc.mdc-berlin.de/19147/1/19147oa.pdf
Publikováno v:
The international journal of biochemistrycell biology. 122
Single cell transcriptomics has emerged as a powerful method for dissecting cell type diversity and for understanding mechanisms of cell fate decisions. However, inclusion of temporal information remains challenging, since each cell can be measured o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e774cb5b9bd22afaed438af59d78d262
https://pubmed.ncbi.nlm.nih.gov/32283227
https://pubmed.ncbi.nlm.nih.gov/32283227
Autor:
Pedro Olivares-Chauvet, Nikolay Ninov, Jan Philipp Junker, Nina Mitic, Bastiaan Spanjaard, B. Hu, Sharan Janjuha
Publikováno v:
Nature biotechnology
Nature Biotechnology
Nature Biotechnology
A key goal of developmental biology is to understand how a single cell is transformed into a full-grown organism comprising many different cell types. Single-cell RNA-sequencing (scRNA-seq) is commonly used to identify cell types in a tissue or organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827c279fb6ae97fc57cc12dbe31995af
https://pubmed.ncbi.nlm.nih.gov/29713013
https://pubmed.ncbi.nlm.nih.gov/29713013