Continuous-flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyproline

Autor: Xacobe C. Cambeiro, Rafael Martín-Rapún, Pedro O. Miranda, Sonia Sayalero, Esther Alza, Patricia Llanes, Miquel A. Pericàs

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 7, Iss 1, Pp 1486-1493 (2011)

The application of polystyrene-immobilized proline-based catalysts in packed-bed reactors for the continuous-flow, direct, enantioselective α-aminoxylation of aldehydes is described. The system allows the easy preparation of a series of β-aminoxy a

Externí odkaz: https://doaj.org/article/513471d0309f451597c9227ae82137ef

Iron(II) and Copper(I) Control the Total Regioselectivity in the Hydrobromination of Alkenes

Autor: Victoria Sinka, Daniel A. Cruz, Pedro de Armas, Israel Fernández, Pedro O. Miranda, Hugo Sebastián Steingruber, Juan I. Padrón, Víctor S. Martín

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Organic Letters

A new method that allows the complete control of the regioselectivity of the hydrobromination reaction of alkenes is described. Herein, we report a radical procedure with TMSBr and oxygen as common reagents, where the formation of the anti-Markovniko

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c73d379e2f9e5ce2d570d4b2c4d889
http://hdl.handle.net/10261/246803

Crystallography Coupled with Kinetic Analysis Provides Mechanistic Underpinnings of a Nicotine-Degrading Enzyme

Autor: Kim D. Janda, Samantha N Muellers, Song Xue, Margarita A. Tararina, Karen N. Allen, Lauren C. Smith, Pedro O. Miranda

Publikováno v: Biochemistry. 57:3741-3751

Nicotine oxidoreductase (NicA2) is a bacterial flavoenzyme, which catalyzes the first step of nicotine catabolism by oxidizing S-nicotine into N-methyl-myosmine. It has been proposed as a biotherapeutic for nicotine addiction because of its nanomolar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca2da6bf8fa192082e91f78cefc21d7
https://doi.org/10.1021/acs.biochem.8b00384

Synthesis of Heterocycles With Iron Salts as Sustainable Metal Catalysts

Autor: Victoria Sinka, Juan I. Padrón, Pedro O. Miranda, Víctor S. Martín, Daniel A. Cruz, Juan M. López-Soria

This chapter rationalizes the different reactivity of the iron salts in the synthesis of a wide variety of heterocycles. It starts by presenting a perspective of the iron inception in universe and its presence on Earth. It then explains its propertie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff3ceb8c08b70490c45e53cb4125904f
https://doi.org/10.1016/b978-0-12-811651-7.00005-4

Iron(III)-Catalyzed Prins Cyclization towards the Synthesis of trans-Fused Bicyclic Tetrahydropyrans

Autor: Daniel A. Cruz, Israel Fernández, Sixto J. Pérez, Juan I. Padrón, Pedro O. Miranda, Víctor S. Martín

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

trans-Fused bicyclic tetrahydropyrans have been synthesized through an intramolecular Prins cyclization catalyzed by iron(III). The cyclization process is stereoselective, leading exclusively to an all-cis configuration in the newly generated ring. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68955e6eeb757064aece05f3bbd26c9
https://doi.org/10.1055/s-0034-1380013