Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Pedro Michelena"'
Autor:
Elvira Bailón, Juan Román, Isabel Ramis, Pedro Michelena, Dolors Balsa, Manuel Merlos, Antonio Zarzuelo, Julio Gálvez, Mònica Comalada
Publikováno v:
Journal of Pharmacological Sciences, Vol 109, Iss 2, Pp 315-318 (2009)
The aim of the present study was to evaluate the inmunomodulatory effects of UR-1505, a new salicylate derivative, on the T helper (Th)2 / humoral response produced during dextran sodium sulfate (DSS)-induced rat colitis. In the in vitro studies, UR-
Externí odkaz:
https://doaj.org/article/3bd372bc9ae4413bb44c5924ef51f0b6
Autor:
Julio Gálvez, Mònica Comalada, Manuel Merlos, Antonio Zarzuelo, Dolors Balsa, Pedro Michelena, Isabel Ramis, Juan Román, Elvira Bailón
Publikováno v:
Journal of Pharmacological Sciences, Vol 109, Iss 2, Pp 315-318 (2009)
The aim of the present study was to evaluate the inmunomodulatory effects of UR-1505, a new salicylate derivative, on the T helper (Th)2 / humoral response produced during dextran sodium sulfate (DSS)-induced rat colitis. In the in vitro studies, UR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d6c2c9255258b9bb98d7260ad1bfb8
http://www.sciencedirect.com/science/article/pii/S134786131934157X
http://www.sciencedirect.com/science/article/pii/S134786131934157X
Autor:
Ángel Concha, Elvira Bailón, Ana Nieto, Isabel Ramis, Pedro Michelena, Juan Román, Manuel Merlos, Antonio Zarzuelo, Mònica Comalada, Julio Gálvez
Publikováno v:
Inflammatory Bowel Diseases. 14:888-897
Background: UR-1505 is a novel salicylate derivative compound that has been demonstrated to selectively down-regulate T-cell activation. The aim of the present study was to elucidate the mechanisms involved in the intestinal anti-inflammatory effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f07a747a63ee63b9447fb8ea7c73c0
https://doi.org/10.1002/ibd.20381
https://doi.org/10.1002/ibd.20381
Autor:
Antonio G. García, Ricardo de Pascual, Pedro Michelena, Mercedes del Valle, Manuel Grau, Carlos J. Herrero, Manuela G. López, Mercedes Villarroya, Emilio Carrasco, Ana Ruiz-Nuño
Publikováno v:
British Journal of Pharmacology. 128:1713-1722
1. PF9404C is the S-S diesteroisomer of a novel blocker of beta adrenergic receptors with vasodilatory properties. It causes a concentration-dependent relaxation of rat aorta helical strips pre-contracted with 10(-6) M noradrenaline (NA; IC(50) 33 nM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f9cadb1d006bc65c593f39f01da0904
https://doi.org/10.1038/sj.bjp.0702992
https://doi.org/10.1038/sj.bjp.0702992
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 360:33-37
In the intact rat adrenal gland perfused with an oxygenated Krebs-bicarbonate solution at 37 degrees C, the electrical field stimulation of splanchnic nerves (100 V, 0.5 ms duration, 10 Hz during 10 s) produced transient catecholamine release peaks t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ba51f372d4b6740555b62ec365f9b0
https://doi.org/10.1007/s002109900041
https://doi.org/10.1007/s002109900041
Autor:
Pedro Michelena, Manuela G. López, Antonio G. García, Baldomero Lara, Luis Gandía, María-Teresa de la Fuente, Teresa Vega
Publikováno v:
The Journal of Physiology. 502:481-496
1. Latrotoxin (LTX, 1-3 nM) caused a gradual increase of the spontaneous catecholamine release rate in bovine adrenal chromaffin cells superfused with normal Krebs-Hepes solution containing 2.5 mM Ca2+. Ca2+ removal abolished this effect. LTX enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bc97437b9ba62016c47a56074e74d4
https://doi.org/10.1111/j.1469-7793.1997.481bj.x
https://doi.org/10.1111/j.1469-7793.1997.481bj.x
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 289:73-80
This study was carried out to define the effects of various Ca2+ channel modulatory drugs on mitochondrial Ca2+ movements. Bovine adrenal medulla mitochondria took up Ca2+ at an initial rate of 6.8 nmol mg protein-1 5 s-1, with a Km of 15 microM and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6325eb2539ec03008086401f7111ddbb
https://doi.org/10.1016/0922-4106(95)90170-1
https://doi.org/10.1016/0922-4106(95)90170-1
Publikováno v:
Restorative neurology and neuroscience. 8(3)
Adult bovine chromaffin cells are generally resistant to plastic changes when exposed to various culture media. Here, we demonstrate that adrenergic-enriched bovine chromaffin cell populations show significant process extension when co-cultured with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b19bcc9abb9a27c145bec489328aaa6
https://pubmed.ncbi.nlm.nih.gov/21551895
https://pubmed.ncbi.nlm.nih.gov/21551895
Publikováno v:
European Journal of Pharmacology. 192:243-251
Cat adrenal glands were perfused at a high rate with various modified Krebs solutions containing different concentrations of K + but no Ca 2+ . Catecholamine release was tested by applying brief Ca 2+ pulses (10 s of a solution containing 120 mM K +
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5633f1595298283909d04db97b6eecba
https://doi.org/10.1016/0014-2999(91)90049-v
https://doi.org/10.1016/0014-2999(91)90049-v
Publikováno v:
Analytical Biochemistry. 185:243-248
Separation of viable adrenaline-containing from noradrenaline-containing chromaffin cells in large amounts has been achieved. The procedure involves collagenase digestion of bovine adrenomedullary tissue, isolation of cells through gentle filtration,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6373bf6a0becc70506f120666a57597d
https://doi.org/10.1016/0003-2697(90)90287-j
https://doi.org/10.1016/0003-2697(90)90287-j