Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors

Autor: Nir Qvit, Deborah Schechtman, Darlene Aparecida Pena, Denise Aparecida Berti, Chrislaine Oliveira Soares, Qianqian Miao, Liying (Annie) Liang, Lauren A. Baron, Christian Teh-Poot, Pedro Martínez-Vega, Maria Jesus Ramirez-Sierra, Eric Churchill, Anna D. Cunningham, Andrey V. Malkovskiy, Nancy A. Federspiel, Fabio Cesar Gozzo, Ana Claudia Torrecilhas, Maria Julia Manso Alves, Armando Jardim, Ndao Momar, Eric Dumonteil, Daria Mochly-Rosen

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 1, Pp 74-84 (2016)

Parasitic diseases cause ∼500,000 deaths annually and remain a major challenge for therapeutic development. Using a rational design based approach, we developed peptide inhibitors with anti-parasitic activity that were derived from the sequences of

Externí odkaz: https://doaj.org/article/4cd893de292342dcb247cf36ee86cb22

Fibronectin degradation as biomarker for

Autor: Nora Adriana, Hernández-Cuevas, Andrea, Marín-Cervera, Shineily, Garcia-Polanco, Pedro, Martínez-Vega, Miguel, Rosado-Vallado, Eric, Dumonteil

Publikováno v: Parasitology. 148(9)

Biomarkers (coming from host or parasite) to monitor Chagas disease (CD) progression as well as the therapeutic response in chronic CD are critically needed, since seronegativization, which may be considered the best indicator of therapeutic cure, ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::baa7fee1667b7c2c7b7a64f23e331a37
https://pubmed.ncbi.nlm.nih.gov/34024298

Associated Factors to Seroprevalence ofEhrlichiaspp. in Dogs of Quintana Roo, Mexico

Autor: Eduardo Gutierrez-Blanco, Sandra Luz Villegas-Perez, Roger Iván Rodríguez-Vivas, Manuel Emilio Bolio-González, Pedro Martínez-Vega, Carlos Pérez-Osorio, Carlos H. Sauri-Arceo

Publikováno v: Journal of Tropical Medicine, Vol 2016 (2016)

The objective of this study was to determine the seroprevalence toEhrlichiaspp. in dogs from Xcalak, Quintana Roo, Mexico, and the associated factors. Serum samples were obtained from 118 dogs and used in an indirect immunofluorescent assay test for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0607af3a90e65e5f99f57ddb6ef15cc
https://doi.org/10.1155/2016/4109467

Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: development of inhibitors

Autor: Darlene Aparecida Pena, Maria Jesus Ramirez-Sierra, Lauren A Baron, Christian Teh-Poot, Andrey V. Malkovskiy, Qianqian Miao, Nir Qvit, Chrislaine Oliveira Soares, Ndao Momar, Liying Annie Liang, Maria Júlia Manso Alves, Eric N. Churchill, Ana Claudia Torrecilhas, Deborah Schechtman, Fabio C. Gozzo, Anna D Cunningham, Nancy A. Federspiel, Eric Dumonteil, Denise Aparecida Berti, Armando Jardim, Daria Mochly-Rosen, Pedro Martínez-Vega

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 1, Pp 74-84 (2016)
International Journal for Parasitology: Drugs and Drug Resistance

Parasitic diseases cause ∼500,000 deaths annually and remain a major challenge for therapeutic development. Using a rational design based approach, we developed peptide inhibitors with anti-parasitic activity that were derived from the sequences of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d974608dd91777b469f10c7301d9ef9

Production of recombinant TSA-1 and evaluation of its potential for the immuno-therapeutic control of Trypanosoma cruzi infection in mice

Autor: Juan Jose de la Cruz, Liliana Villanueva-Lizama, Victor Dzul-Huchim, María-Jesus Ramírez-Sierra, Pedro Martinez-Vega, Miguel Rosado-Vallado, Jaime Ortega-Lopez, Claudia Ivonne Flores-Pucheta, Portia Gillespie, Bin Zhan, Maria Elena Bottazzi, Peter J. Hotez, Eric Dumonteil

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 15, Iss 1, Pp 210-219 (2019)

A therapeutic vaccine for human Chagas disease (American trypanosomiasis caused by Trypanosoma cruzi) is under development based on the success of vaccinating mice with DNA constructs expressing the antigens Tc24 and Tc-TSA-1. However, because DNA an

Externí odkaz: https://doaj.org/article/539cfa6032b84113ab27eea2495a768b