Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Pedro M. Quirós"'
Autor:
Mario K. Shammas, Xiaoping Huang, Beverly P. Wu, Evelyn Fessler, Insung Y. Song, Nicholas P. Randolph, Yan Li, Christopher K.E. Bleck, Danielle A. Springer, Carl Fratter, Ines A. Barbosa, Andrew F. Powers, Pedro M. Quirós, Carlos Lopez-Otin, Lucas T. Jae, Joanna Poulton, Derek P. Narendra
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 14 (2022)
Mitochondrial stress triggers a response in the cell’s mitochondria and nucleus, but how these stress responses are coordinated in vivo is poorly understood. Here, we characterize a family with myopathy caused by a dominant p.G58R mutation in the m
Externí odkaz:
https://doaj.org/article/ef70aa06d2af4caebf5831735eb5446d
Autor:
Pedro M. Quirós, Yaiza Español, Rebeca Acín-Pérez, Francisco Rodríguez, Clea Bárcena, Kenta Watanabe, Enrique Calvo, Marta Loureiro, M. Soledad Fernández-García, Antonio Fueyo, Jesús Vázquez, José Antonio Enríquez, Carlos López-Otín
Publikováno v:
Cell Reports, Vol 8, Iss 2, Pp 542-556 (2014)
We generated mice deficient in Lon protease (LONP1), a major enzyme of the mitochondrial quality control machinery. Homozygous deletion of Lonp1 causes early embryonic lethality, whereas its haploinsufficiency protects against colorectal and skin tum
Externí odkaz:
https://doaj.org/article/c628e3a772344fb6bec50e4f632d1921
Autor:
Mario K. Shammas, Xiaoping Huang, Beverly P. Wu, Insung Song, Nicholas Randolph, Yan Li, Christopher K. E. Bleck, Danielle A. Springer, Carl Fratter, Ines A. Barbosa, Andrew F. Powers, Pedro M. Quirós, Carlos Lopez-Otin, Joanna Poulton, Derek P. Narendra
Mitochondrial stress triggers a response in the cell’s mitochondria and nucleus, but how these stress responses are coordinated in vivo is poorly understood. Here, we characterize a family with myopathy caused by a dominant p.G58R mutation in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa7193f7a8255862d65cb36d7304cd88
https://doi.org/10.1101/2021.12.21.473493
https://doi.org/10.1101/2021.12.21.473493
Autor:
Tatsuya Yamada, Kenta Arai, Hiromi Sesaki, Takeshi Tokuyama, Pedro M. Quirós, Carlos López-Otín, Daisuke Murata, Miho Iijima
Publikováno v:
EMBO J
The connectivity of mitochondria is regulated by a balance between fusion and division. Many human diseases are associated with excessive mitochondrial connectivity due to impaired Drp1, a dynamin-related GTPase that mediates division. Here, we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548142da56a9788900539af17059b42d
https://europepmc.org/articles/PMC7737612/
https://europepmc.org/articles/PMC7737612/
Publikováno v:
Philos Trans R Soc Lond B Biol Sci
Endosymbiotic organelles of eukaryotic cells, the plastids, including chloroplasts and mitochondria, are highly integrated into cellular signalling networks. In both heterotrophic and autotrophic organisms, plastids and/or mitochondria require extens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f499ebd1bb279934e4d6f7b97db66d33
https://europepmc.org/articles/PMC7209961/
https://europepmc.org/articles/PMC7209961/
Autor:
Berthold Göttgens, Xiaonan Wang, David J. Adams, Larissa S. Carnevalli, Kim Wong, George S. Vassiliou, Alison Kennedy, George Giotopoulos, Konstantinos Tzelepis, Brian J. P. Huntly, Sarah Kinston, Fernando J Calero-Nieto, Pedro M. Quirós, Silvia Basilico
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Leukaemogenic mutations commonly disrupt cellular differentiation and/or enhance proliferation, thus perturbing the regulatory programs that control self-renewal and differentiation of stem and progenitor cells. Translocations involving the Mll1 (Kmt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773633fe21e5017797281f2b08b2d3b3
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications
Nature Communications
Age-associated changes in chromatin structure have a major impact on organismal longevity. Despite being a central part of the ageing process, the organismal responses to the changes in chromatin organization remain unclear. Here we show that moderat
Publikováno v:
Current Protocols in Mouse Biology
Mitochondrial DNA (mtDNA) lacks the protection provided by the nucleosomes in the nuclear DNA and does not have a DNA repair mechanism, making it highly susceptible to damage, which can lead to mtDNA depletion. mtDNA depletion compromises the efficie
Autor:
Josep F. Nomdedeu, Swee Hoe Ong, Yasuhito Nannya, Seishi Ogawa, George S. Vassiliou, Faisal Basheer, Mario Cazzola, Roland Rad, Muxin Gu, Pedro M. Quirós, M. S. Vijayabaskar, Adam Butler, Maximillian Zwiebel, Nick Boughton
Publikováno v:
Haematologica
HAEMATOLOGICA
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
HAEMATOLOGICA
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Acute myeloid leukemia (AML) is an aggressive malignancy of haematopoietic stem cells driven by a well-defined set of somatic mutations.1,2 Identifying the mutations driving individual cases is important for assigning the patient to a recognized Worl
Autor:
Alejandro Lucia, Guido Kroemer, Nuria Salazar, Clea Bárcena, Cecilia Garabaya, Pablo Mayoral, Francisco Rodríguez, Noélie Bossut, Fanny Aprahamian, Rafael Valdés-Mas, Alicja Nogacka, María Teresa Fernández-García, José M.P. Freije, Nuria Garatachea, Pedro M. Quirós, Sylvère Durand, Carlos López-Otín
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Medicine
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Nature Medicine
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
The gut microbiome is emerging as a key regulator of several metabolic, immune and neuroendocrine pathways1,2. Gut microbiome deregulation has been implicated in major conditions such as obesity, type 2 diabetes, cardiovascular disease, non-alcoholic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321936013b456dd4601b59a285ec51a7
http://hdl.handle.net/10261/201876
http://hdl.handle.net/10261/201876