Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Pedro M. Fernández Salguero"'
Liver regeneration after partial hepatectomy is improved in the absence of aryl hydrocarbon receptor
Autor:
Claudia M. Rejano-Gordillo, Francisco J. González-Rico, Beatriz Marín-Díaz, Ana Ordiales-Talavero, Ana Nacarino-Palma, Ángel C. Román, Jaime M. Merino, Pedro M. Fernández-Salguero
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The liver is among the few organs having the ability to self-regenerate in response to a severe damage compromising its functionality. The Aryl hydrocarbon receptor (Ahr) is a transcription factor relevant for the detoxification of xenobioti
Externí odkaz:
https://doaj.org/article/9c1c382cfec64853a9458bdb939a35a0
Autor:
Gary H. Perdew, Charlotte Esser, Megan Snyder, David H. Sherr, Ellen H. van den Bogaard, Karen McGovern, Pedro M. Fernández-Salguero, Xavier Coumoul, Andrew D. Patterson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5550 (2023)
The aryl hydrocarbon receptor (AHR) is a sensor of low-molecular-weight molecule signals that originate from environmental exposures, the microbiome, and host metabolism. Building upon initial studies examining anthropogenic chemical exposures, the l
Externí odkaz:
https://doaj.org/article/51868d43c72e45e9b088150fefa88fb8
Autor:
Claudia Rejano-Gordillo, Ana Ordiales-Talavero, Ana Nacarino-Palma, Jaime M. Merino, Francisco J. González-Rico, Pedro M. Fernández-Salguero
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Transcription factor aryl hydrocarbon receptor (AHR) has emerged as one of the main regulators involved both in different homeostatic cell functions and tumor progression. Being a member of the family of basic-helix-loop-helix (bHLH) transcriptional
Externí odkaz:
https://doaj.org/article/5d6188d03a7744bda9c345cb48a8ab3c
Autor:
Francisco J. González-Rico, Cristina Vicente-García, Almudena Fernández, Diego Muñoz-Santos, Lluís Montoliu, Antonio Morales-Hernández, Jaime M. Merino, Angel-Carlos Román, Pedro M. Fernández-Salguero
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-13 (2020)
Abstract Transcriptional repression of Nanog is an important hallmark of stem cell differentiation. Chromatin modifications have been linked to the epigenetic profile of the Nanog gene, but whether chromatin organization actually plays a causal role
Externí odkaz:
https://doaj.org/article/434edba6cc424458a09bce6320a68889
Autor:
Claudia M. Rejano-Gordillo, Beatriz Marín-Díaz, Ana Ordiales-Talavero, Jaime M. Merino, Francisco J. González-Rico, Pedro M. Fernández-Salguero
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14919 (2022)
The aryl hydrocarbon receptor (AHR) is a markedly established regulator of a plethora of cellular and molecular processes. Its initial role in the detoxification of xenobiotic compounds has been partially overshadowed by its involvement in homeostati
Externí odkaz:
https://doaj.org/article/686c4fc6665d44209d1c8ab89fd05408
Autor:
Nuria Moreno-Marín, Jaime M. Merino, Alberto Alvarez-Barrientos, Daxeshkumar P. Patel, Shogo Takahashi, José M. González-Sancho, Pablo Gandolfo, Rosa M. Rios, Alberto Muñoz, Frank J. Gonzalez, Pedro M. Fernández-Salguero
Publikováno v:
iScience, Vol 4, Iss , Pp 44-63 (2018)
Summary: Aryl hydrocarbon receptor (AhR) deficiency alters tissue homeostasis. However, how AhR regulates organ maturation and differentiation remains mostly unknown. Liver differentiation entails a polyploidization process fundamental for cell growt
Externí odkaz:
https://doaj.org/article/b8c3084a846b451d94deec93ea66ff17
Autor:
Angel-Carlos Román, Julián Vicente-Page, Alfonso Pérez-Escudero, Jose M. Carvajal-González, Pedro M. Fernández-Salguero, Gonzalo G. de Polavieja
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-21 (2018)
Abstract Background Animals can show very different behaviors even in isogenic populations, but the underlying mechanisms to generate this variability remain elusive. We use the zebrafish (Danio rerio) as a model to test the influence of histone modi
Externí odkaz:
https://doaj.org/article/df66a53a073b431b9e2aa0577fcd5c9e
Autor:
Antonio Morales-Hernández, Ana Nacarino-Palma, Nuria Moreno-Marín, Eva Barrasa, Beroé Paniagua-Quiñones, Inmaculada Catalina-Fernández, Alberto Alvarez-Barrientos, Xosé R. Bustelo, Jaime M. Merino, Pedro M. Fernández-Salguero
Publikováno v:
Stem Cell Research, Vol 25, Iss C, Pp 61-71 (2017)
Recent experimental evidences from cellular systems and from mammalian and non-mammalian animal models highlight novel functions for the aryl hydrocarbon/dioxin receptor (AhR) in maintaining cell differentiation and tissue homeostasis. Notably, AhR d
Externí odkaz:
https://doaj.org/article/74e389c33455468884dfe53c82f0a8c7
Autor:
Ana Nacarino-Palma, Pedro M. Fernández-Salguero, Jaime M. Merino, Francisco J. González-Rico, Claudia M. Rejano-Gordillo, Ana Ordiales-Talavero
Publikováno v:
Stem Cell Reports
Summary Mammalian embryogenesis is a complex process controlled by transcription factors that regulate the balance between pluripotency and differentiation. Transcription factor aryl hydrocarbon receptor (AhR) regulates OCT4/POU5F1 and NANOG, both es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63871c8ddec17aaf29399e6aa5386c89
http://europepmc.org/articles/PMC8452532
http://europepmc.org/articles/PMC8452532
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 4 (2016)
Traditionally considered as a critical intermediate in the toxic and carcinogenic response to dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD), the Aryl hydrocarbon/Dioxin receptor (AhR) has proven to be also an important regulator of cell physiolo
Externí odkaz:
https://doaj.org/article/dfe643798ed54a2c8f256a89b9ad1d6e