Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Pedro M. Enriquez-Navas"'
Autor:
Alexander R.A. Anderson, Robert A. Gatenby, Kimberly A. Luddy, Pedro M. Enriquez-Navas, Jill A. Gallaher
Comparing CT, AT1, and AT2 treatment schedules for a heterogeneous sensitive tumor when cells can migrate. Tumors were initialized by a normal distribution with a mean sensitivity s=100% and standard deviation σs=25%.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466c5677e814c0ce512636105fe26fcf
https://doi.org/10.1158/0008-5472.22417508
https://doi.org/10.1158/0008-5472.22417508
Autor:
Alexander R.A. Anderson, Robert A. Gatenby, Kimberly A. Luddy, Pedro M. Enriquez-Navas, Jill A. Gallaher
Comparing CT, AT1, and AT2 treatment schedules for a homogeneous sensitive tumor initialized by a normal distribution with a mean sensitivity s=100% and standard deviation σs=5%.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76607f72f01b5e7096b899a8fb47b226
https://doi.org/10.1158/0008-5472.22417520
https://doi.org/10.1158/0008-5472.22417520
Autor:
Robert A. Gatenby, Robert J. Gillies, Alexander R.A. Anderson, Joel S. Brown, Marilyn M. Bui, Mark C. Lloyd, Kam Yoonseok, Shonagh Russell, Jonathan W. Wojtkowiak, Yoganand Balagurunathan, Mehdi Damaghi, Pedro M. Enriquez-Navas, Mark Robertson-Tessi, Arig Ibrahim-Hashim
Ongoing intratumoral evolution is apparent in molecular variations among cancer cells from different regions of the same tumor, but genetic data alone provide little insight into environmental selection forces and cellular phenotypic adaptations that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b349c40659fe01e66d9e538ca5181b0
https://doi.org/10.1158/0008-5472.c.6510057
https://doi.org/10.1158/0008-5472.c.6510057
Autor:
Alexander R.A. Anderson, Robert A. Gatenby, Kimberly A. Luddy, Pedro M. Enriquez-Navas, Jill A. Gallaher
Comparing CT, AT1, and AT2 treatment schedules for a heterogeneous sensitive tumor when phenotypes can drift. Tumors were initialized by a normal distribution with a mean sensitivity s=80% and standard deviation σs=25%.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a312b5c9acd6de6952e3559785cc4ec
https://doi.org/10.1158/0008-5472.22417505
https://doi.org/10.1158/0008-5472.22417505
Autor:
Alexander R.A. Anderson, Robert A. Gatenby, Kimberly A. Luddy, Pedro M. Enriquez-Navas, Jill A. Gallaher
Treatment of advanced cancers has benefited from new agents that supplement or bypass conventional therapies. However, even effective therapies fail as cancer cells deploy a wide range of resistance strategies. We propose that evolutionary dynamics u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835bdc8be1a0b6a6f22a80ade4e2d069
https://doi.org/10.1158/0008-5472.c.6509867.v1
https://doi.org/10.1158/0008-5472.c.6509867.v1
Autor:
Robert A. Gatenby, Robert J. Gillies, Alexander R.A. Anderson, Joel S. Brown, Marilyn M. Bui, Mark C. Lloyd, Kam Yoonseok, Shonagh Russell, Jonathan W. Wojtkowiak, Yoganand Balagurunathan, Mehdi Damaghi, Pedro M. Enriquez-Navas, Mark Robertson-Tessi, Arig Ibrahim-Hashim
Simultaneous video of four simulations of tumor growth with accompanying phenotypic "flow" diagram, Top left: untreated; top right: low dose, early; bottom left: high dose, late; bottom right: low dose, late. The appearance of the white box in each o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f448ee4f0ea507d017699912426172b
https://doi.org/10.1158/0008-5472.22418178
https://doi.org/10.1158/0008-5472.22418178
Autor:
Robert A. Gatenby, Robert J. Gillies, Alexander R.A. Anderson, Joel S. Brown, Marilyn M. Bui, Mark C. Lloyd, Kam Yoonseok, Shonagh Russell, Jonathan W. Wojtkowiak, Yoganand Balagurunathan, Mehdi Damaghi, Pedro M. Enriquez-Navas, Mark Robertson-Tessi, Arig Ibrahim-Hashim
Supplemental material contains additional details of tumor imaging and mathematical models. Supplemental figures demonstrating results from experimental and computational studies referenced in the manuscript are included
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4919a7b02bee9a2c20b4b1e0dae6b1a7
https://doi.org/10.1158/0008-5472.22418181.v1
https://doi.org/10.1158/0008-5472.22418181.v1
Autor:
Alexander R.A. Anderson, Robert A. Gatenby, Kimberly A. Luddy, Pedro M. Enriquez-Navas, Jill A. Gallaher
Comparing CT, AT1, and AT2 treatment schedules for a homogeneous resistant tumor initialized by a normal distribution with a mean sensitivity s=60% and standard deviation σs=5%.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa617e0a45b1175da050c5d2a0c2985
https://doi.org/10.1158/0008-5472.22417514
https://doi.org/10.1158/0008-5472.22417514
Autor:
Robert A. Gatenby, Joel S. Brown, Marilyn M. Bui, Sultan Damgaci, Pedro M. Enriquez-Navas, Jiqiang Yao, Dominique Abrahams, Arig Ibrahim-Hashim, Luddy K, Cliona O'Farrelly, Christina L. Richards, Tingan Chen, Robert J. Gillies
Publikováno v:
British Journal of Cancer
Background Cancer progression is governed by evolutionary dynamics in both the tumour population and its host. Since cancers die with the host, each new population of cancer cells must reinvent strategies to overcome the host’s heritable defences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6815043bce83b934e9808f5096dccfbb
https://doi.org/10.1038/s41416-020-01110-1
https://doi.org/10.1038/s41416-020-01110-1
Autor:
Dario Livio Longo, Arig Ibrahim-Hashim, Matthew Beatty, Mehdi Damaghi, Robert J. Gillies, Pedro M. Enriquez-Navas, Kimberly Luddy, Anna Moshnikova, Pawel Swietach, Shari Pilon-Thomas, Hao Wu, Dominique Abrahams, Shonagh Russell, Krithika Kodumudi, Veronica Estrella, Asmaa El-Kenawi, Smitha Pillai, Yana K. Reshetnyak, Oleg A. Andreev
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nat Commun
Nature Communications
Nat Commun
The acidic pH of tumors profoundly inhibits effector functions of activated CD8 + T-cells. We hypothesize that this is a physiological process in immune regulation, and that it occurs within lymph nodes (LNs), which are likely acidic because of low c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df969201dbc11c0cce79f6d53626090
https://doaj.org/article/8a725d35fbca44839f00a263e2a935bc
https://doaj.org/article/8a725d35fbca44839f00a263e2a935bc