Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Pedro M B M Coelho"'
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
The NADPH redox cycle plays a key role in antioxidant protection of human erythrocytes. It consists of two enzymes: glucose-6-phosphate dehydrogenase (G6PD) and glutathione reductase. Over 160 G6PD variants have been characterized and associated with
Externí odkaz:
https://doaj.org/article/e74bed387bc4443ea10a078c18d5cc51
Quantifying global tolerance of biochemical systems: design implications for moiety-transfer cycles.
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 3, p e1000319 (2009)
Robustness of organisms is widely observed although difficult to precisely characterize. Performance can remain nearly constant within some neighborhood of the normal operating regime, leading to homeostasis, but then abruptly break down with patholo
Externí odkaz:
https://doaj.org/article/ccdf787ec7fe4462b568510a8b40c94a
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Redox Biology, Vol 15, Iss C, Pp 297-315 (2018)
Redox Biology
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Redox Biology, Vol 15, Iss C, Pp 297-315 (2018)
Redox Biology
The system (PTTRS) formed by typical 2-Cys peroxiredoxins (Prx), thioredoxin (Trx), Trx reductase (TrxR), and sulfiredoxin (Srx) is central in antioxidant protection and redox signaling in the cytoplasm of eukaryotic cells. Understanding how the PTTR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6918967386841588e732698bfc3a18
https://doi.org/10.1101/224428
https://doi.org/10.1101/224428
Publikováno v:
Proceedings of the National Academy of Sciences. 106:6435-6440
One of the major unsolved problems of modern biology is deep understanding of the complex relationship between the information encoded in the genome of an organism and the phenotypic properties manifested by that organism. Fundamental advances must b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b487833c21ec960bf04b31e25f01a59e
https://doi.org/10.1073/pnas.0809869106
https://doi.org/10.1073/pnas.0809869106
Publikováno v:
Free radical biologymedicine. 75
Cells are occasionally exposed to high H2O2 concentrations, often preceding exposure to other electrophylic compounds. Both H2O2 and these compounds can irreversibly modify protein thiols, with deleterious consequences. Induction of enzymatic defense
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e23480b0e54049d23ad04c1e06a9f7
https://pubmed.ncbi.nlm.nih.gov/26461388
https://pubmed.ncbi.nlm.nih.gov/26461388
Publikováno v:
Free radical biologymedicine. 74
Hydrogen peroxide (H 2 O 2 ) metabolism in human erythrocytes has been thoroughly investigated, but unclear points persist. By integrating the available data into a mathematical model that accurately represents the current understanding and comparing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd4d8b4811ef9d25873ea3731f5dbff
https://pubmed.ncbi.nlm.nih.gov/24952139
https://pubmed.ncbi.nlm.nih.gov/24952139
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
PLoS ONE
PLoS ONE
Background The NADPH redox cycle plays a key role in antioxidant protection of human erythrocytes. It consists of two enzymes: glucose-6-phosphate dehydrogenase (G6PD) and glutathione reductase. Over 160 G6PD variants have been characterized and asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85add7292c4db5ff169042d95f295aa
https://doi.org/10.1371/journal.pone.0013031
https://doi.org/10.1371/journal.pone.0013031