A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells.

Autor: Valentina Cigliola, Celine Populaire, Ciro L Pierri, Samuel Deutsch, Jacques-Antoine Haefliger, João Fadista, Valeriya Lyssenko, Leif Groop, Rico Rueedi, Fabrizio Thorel, Pedro Luis Herrera, Paolo Meda

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0150880 (2016)

Signalling through gap junctions contributes to control insulin secretion and, thus, blood glucose levels. Gap junctions of the insulin-producing β-cells are made of connexin 36 (Cx36), which is encoded by the GJD2 gene. Cx36-null mice feature alter

Externí odkaz: https://doaj.org/article/235ee19e0b3f4349a307a413ec2ed52d

Islet transplantation tolerance in animals with defined histocompatibility and diabetes

Autor: Preksha Bhagchandani, Seung K. Kim, Charles A. Chang, Simona Chera, Pedro Luis Herrera, Weichen Zhao, Luiza Ghila

SummaryAdvances in organ transplantation benefit from development of genetically inbred animal strains with defined histocompatibility and cell-specific markers to distinguish donor and host cell subsets. For studies of pancreatic islet transplantati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3600b4168df29319edcb63b206c232e0
https://doi.org/10.1101/2021.10.08.463702

Author Correction: Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production

Autor: Eva Bru-Tari, Fabrizio Thorel, Valentina Cigliola, Marta Perez-Frances, Kenichiro Furuyama, Yoshio Fujitani, Daniel Oropeza, Maria Valentina Abate, Pedro Luis Herrera, Taïna Carreaux, Léon van Gurp

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Nature Communications

The cellular identity of pancreatic polypeptide (Ppy)-expressing γ-cells, one of the rarest pancreatic islet cell-type, remains elusive. Within islets, glucagon and somatostatin, released respectively from α- and δ-cells, modulate the secretion of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54515858712191638e7187dbfd706bbb
https://doi.org/10.1038/s41467-021-26062-9

Ultrafast pulse shaping modulates perceived visual brightness in living animals

Autor: Matteo Montagnese, Ursula Rothlisberger, Pedro Luis Herrera, Adrien Chauvet, Sylvain Hermelin, Luigi Bonacina, Ivan Rodriguez, Geoffrey Gaulier, Cédric Schmidt, Swarnendu Bhattacharyya, Florence Chiodini, Jean-Pierre Wolf, Quentin Dietschi

Publikováno v: Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (18), pp.eabe1911. ⟨10.1126/sciadv.abe1911⟩
Science Advances, Vol. 7, No 18 (2021) P. eabe1911

Vision in living mice is sensitive to femtosecond pulse shaping.
Vision is usually assumed to be sensitive to the light intensity and spectrum but not to its spectral phase. However, experiments performed on retinal proteins in solution showed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbdcf4d83b37f33b9fdc8e1ded0d6d0
https://hal.archives-ouvertes.fr/hal-03220160

Generation and characterization of a novel mouse model that allows spatiotemporal quantification of pancreatic β-cell proliferation

Autor: Shinsuke Tokumoto, Hisato Tatsuoka, Daisuke Yabe, Pedro Luis Herrera, Nobuya Inagaki, Muhammad Fauzi, Ainur Botagarova, Ryota Usui, Masahito Ogura, Hisanori Goto

Publikováno v: Diabetes
Diabetes (2020) P. db200290

Pancreatic β-cell proliferation has been gaining much attention as a therapeutic target for prevention and treatment of diabetes. In order to evaluate potential β-cell mitogens, accurate and reliable methods for detection and quantification of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b30c59a0a7b826f084e192855c81eb4
https://doi.org/10.2337/figshare.12753533