Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Pedro L Vera"'
Autor:
Shaojing Ye, Fei Ma, Dlovan F D Mahmood, Katherine L Meyer-Siegler, Raymond E Menard, David E Hunt, Lin Leng, Richard Bucala, Pedro L Vera
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255975 (2021)
BackgroundActivation of intravesical protease activated receptor 4 (PAR4) leads to release of urothelial macrophage migration inhibitory factor (MIF). MIF then binds to urothelial MIF receptors to release urothelial high mobility group box-1 (HMGB1)
Externí odkaz:
https://doaj.org/article/7fc27f72d7f44943824ab56be9a0a3f1
Autor:
Dimitrios E Kouzoukas, Fei Ma, Katherine L Meyer-Siegler, Karin N Westlund, David E Hunt, Pedro L Vera
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152055 (2016)
Pain is the significant presenting symptom in Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS). Activation of urothelial protease activated receptor 4 (PAR4) causes pain through release of urothelial macrophage migration inhibitory factor (MIF
Externí odkaz:
https://doaj.org/article/57dc9127402e4673849ef02be46a4e7a
Autor:
Dimitrios E Kouzoukas, Katherine L Meyer-Siegler, Fei Ma, Karin N Westlund, David E Hunt, Pedro L Vera
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127628 (2015)
Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, is constitutively expressed in urothelial cells that also express protease-activated receptors (PAR). Urothelial PAR1 receptors were shown to mediate bladder inflammation. We
Externí odkaz:
https://doaj.org/article/3dcc359c5d574d26aacafec01a36b1c6
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15904 (2010)
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine expressed by urothelial cells that mediates bladder inflammation. We investigated the effect of stimulation with thrombin, a Protease Activated Receptor-1 (PAR1) agonist, on
Externí odkaz:
https://doaj.org/article/5257ff2541a94e42a8d1a6b6f23c4391
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5835 (2009)
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine constitutively expressed by urothelial cells. During inflammatory stimuli, MIF is released into the lumen complexed to other proteins and these complexes can bind to urotheli
Externí odkaz:
https://doaj.org/article/f35619e7c29e4312a553135ec7add1bf
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3898 (2008)
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine involved in cystitis and a non-cognate ligand of the chemokine receptor CXCR4 in vitro. We studied whether CXCR4-MIF associations occur in rat bladder and the effect of exper
Externí odkaz:
https://doaj.org/article/16d3551986d5449dbd28298f5c1c2751
Publikováno v:
Cells, Vol 12, Iss 10, p 1440 (2023)
Activation of intravesical protease activated receptors-4 (PAR4) results in bladder pain through the release of urothelial macrophage migration inhibitory factor (MIF) and high mobility group box-1 (HMGB1). We aimed to identify HMGB1 downstream signa
Externí odkaz:
https://doaj.org/article/82bc35badbbd4cbea950db9ba173d0ad
Autor:
Shaojing Ye, Fei Ma, Dlovan F. D. Mahmood, Katherine L. Meyer-Siegler, Lin Leng, Richard Bucala, Pedro L. Vera
Publikováno v:
Frontiers in Systems Neuroscience. 16
Activation of intravesical PAR4 receptors leads to bladder hyperalgesia (BHA) through release of urothelial macrophage migration inhibitory factor (MIF) and urothelial high mobility group box-1 (HMGB1). MIF deficiency and/or MIF antagonism at the bla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8366937cd8b538a6c80e9dff60bdb315
Autor:
Fei Ma, Shaojing Ye, David E. Hunt, Dlovan F. D. Mahmood, Pedro L. Vera, Richard Bucala, Lin Leng, Raymond E. Menard, Katherine L. Meyer-Siegler
Publikováno v:
Journal of Urology. 206
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1479cf5fc7c80d8a10876bbd9b99fbdd
https://doi.org/10.1097/ju.0000000000001981.05
https://doi.org/10.1097/ju.0000000000001981.05
Publikováno v:
Neuroscience Letters. 699:54-58
Repeated intravesical PAR4 (protease activated receptor 4) activation elicits persistent bladder pain lasting 5 days after the last treatment. Persistent bladder pain was fully reversed by a systemic HMGB1 (high mobility group box 1) inhibitor while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e97dd0015f581e9e9fbb62294e94e7
https://doi.org/10.1016/j.neulet.2019.01.046
https://doi.org/10.1016/j.neulet.2019.01.046