Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Pedro L Vera"'
Publikováno v:
Cells, Vol 12, Iss 10, p 1440 (2023)
Activation of intravesical protease activated receptors-4 (PAR4) results in bladder pain through the release of urothelial macrophage migration inhibitory factor (MIF) and high mobility group box-1 (HMGB1). We aimed to identify HMGB1 downstream signa
Externí odkaz:
https://doaj.org/article/82bc35badbbd4cbea950db9ba173d0ad
Autor:
Shaojing Ye, Fei Ma, Dlovan F. D. Mahmood, Katherine L. Meyer-Siegler, Lin Leng, Richard Bucala, Pedro L. Vera
Publikováno v:
Frontiers in Systems Neuroscience, Vol 16 (2022)
Activation of intravesical PAR4 receptors leads to bladder hyperalgesia (BHA) through release of urothelial macrophage migration inhibitory factor (MIF) and urothelial high mobility group box-1 (HMGB1). MIF deficiency and/or MIF antagonism at the bla
Externí odkaz:
https://doaj.org/article/3284f4e872984456b434bfe7fc5731f7
Autor:
Shaojing Ye, Fei Ma, Dlovan F D Mahmood, Katherine L Meyer-Siegler, Raymond E Menard, David E Hunt, Lin Leng, Richard Bucala, Pedro L Vera
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255975 (2021)
BackgroundActivation of intravesical protease activated receptor 4 (PAR4) leads to release of urothelial macrophage migration inhibitory factor (MIF). MIF then binds to urothelial MIF receptors to release urothelial high mobility group box-1 (HMGB1)
Externí odkaz:
https://doaj.org/article/7fc27f72d7f44943824ab56be9a0a3f1
Autor:
Dimitrios E Kouzoukas, Fei Ma, Katherine L Meyer-Siegler, Karin N Westlund, David E Hunt, Pedro L Vera
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152055 (2016)
Pain is the significant presenting symptom in Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS). Activation of urothelial protease activated receptor 4 (PAR4) causes pain through release of urothelial macrophage migration inhibitory factor (MIF
Externí odkaz:
https://doaj.org/article/57dc9127402e4673849ef02be46a4e7a
Autor:
Fei Ma, Shaojing Ye, David E. Hunt, Dlovan F. D. Mahmood, Pedro L. Vera, Richard Bucala, Lin Leng, Raymond E. Menard, Katherine L. Meyer-Siegler
Publikováno v:
Journal of Urology. 206
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1479cf5fc7c80d8a10876bbd9b99fbdd
https://doi.org/10.1097/ju.0000000000001981.05
https://doi.org/10.1097/ju.0000000000001981.05
Autor:
Dimitrios E Kouzoukas, Katherine L Meyer-Siegler, Fei Ma, Karin N Westlund, David E Hunt, Pedro L Vera
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127628 (2015)
Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, is constitutively expressed in urothelial cells that also express protease-activated receptors (PAR). Urothelial PAR1 receptors were shown to mediate bladder inflammation. We
Externí odkaz:
https://doaj.org/article/3dcc359c5d574d26aacafec01a36b1c6
Publikováno v:
Neuroscience Letters. 699:54-58
Repeated intravesical PAR4 (protease activated receptor 4) activation elicits persistent bladder pain lasting 5 days after the last treatment. Persistent bladder pain was fully reversed by a systemic HMGB1 (high mobility group box 1) inhibitor while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e97dd0015f581e9e9fbb62294e94e7
https://doi.org/10.1016/j.neulet.2019.01.046
https://doi.org/10.1016/j.neulet.2019.01.046
Autor:
Alexander Christie, Margaret Higgins, Sandeep Kumar, Pedro L. Vera, Matthew Lane, David Preston
Publikováno v:
Urology. 126:116-120
To examine the relationship between phosphodiesterase 5 inhibitor drugs (PDE5i) and skin cancers in a large-scale study of Veterans.This was a retrospective database review using the Department of Veterans Affairs Informatics and Computing Infrastruc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1be25e2a5b8aecb8051642bd73871f
https://doi.org/10.1016/j.urology.2019.01.025
https://doi.org/10.1016/j.urology.2019.01.025
Publikováno v:
International Journal of Urology. 25:887-893
OBJECTIVES: To develop a rodent model of persistent non-inflammatory bladder pain and to test macrophage migration inhibitory factor and high mobility box group 1 as mediators of bladder pain. METHODS: Female C57BL/6 mice received intravesical instil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab4e2219c5afcb439cb213794db31f2
https://doi.org/10.1111/iju.13778
https://doi.org/10.1111/iju.13778
Autor:
Robert M. Moldwin, Pedro L. Vera, Deborah R. Erickson, Magnus Fall, Fei Ma, Behzad Mowlazadeh, Dimitrios E. Kouzoukas, David Preston, Katherine L. Meyer-Siegler
Publikováno v:
Urology. 116:55-62
Objective To investigate whether urinary levels of macrophage migration inhibitory factor (MIF) are elevated in interstitial cystitis/bladder pain syndrome (IC/BPS) patients with Hunner lesions and also whether urine MIF is elevated in other forms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e2f2cf61ce5303d2939c12fd77f3b8
https://doi.org/10.1016/j.urology.2018.02.039
https://doi.org/10.1016/j.urology.2018.02.039