Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Pedro L, Herrera"'
Autor:
Léon van Gurp, Leon Fodoulian, Daniel Oropeza, Kenichiro Furuyama, Eva Bru-Tari, Anh Nguyet Vu, John S. Kaddis, Iván Rodríguez, Fabrizio Thorel, Pedro L. Herrera
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/c9bad23815644e399854264568da3129
Autor:
Preksha Bhagchandani, Charles A. Chang, Weichen Zhao, Luiza Ghila, Pedro L. Herrera, Simona Chera, Seung K. Kim
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Improved models of experimental diabetes are needed to develop cell therapies for diabetes. Here, we introduce the B6 RIP-DTR mouse, a model of experimental diabetes in fully immunocompetent animals. These inbred mice harbor the H2b major hi
Externí odkaz:
https://doaj.org/article/9f14e82940fb47cfa087063f5419f40c
Autor:
Léon van Gurp, Leon Fodoulian, Daniel Oropeza, Kenichiro Furuyama, Eva Bru-Tari, Anh Nguyet Vu, John S. Kaddis, Iván Rodríguez, Fabrizio Thorel, Pedro L. Herrera
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Abstract Generation of surrogate cells with stable functional identities is crucial for developing cell-based therapies. Efforts to produce insulin-secreting replacement cells to treat diabetes require reliable tools to assess islet cellular identity
Externí odkaz:
https://doaj.org/article/98f4555862884fd79c46027b0e72ef4c
Autor:
Daniel Oropeza, Valentina Cigliola, Agustín Romero, Simona Chera, Santiago A. Rodríguez-Seguí, Pedro L. Herrera
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Loss of pancreatic insulin-secreting β-cells due to metabolic or autoimmune damage leads to the development of diabetes. The discovery that α-cells can be efficiently reprogrammed into insulin-secreting cells in mice and humans
Externí odkaz:
https://doaj.org/article/b29c2a4dfad14e59991b1d7250684b8c
Autor:
Marta Perez-Frances, Léon van Gurp, Maria Valentina Abate, Valentina Cigliola, Kenichiro Furuyama, Eva Bru-Tari, Daniel Oropeza, Taïna Carreaux, Yoshio Fujitani, Fabrizio Thorel, Pedro L. Herrera
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The cellular identity and function of the pancreatic polypeptide (Ppy)-producing γ-cells are incompletely understood. Here the authors show that these cells are heterogeneous and display adaptive plasticity to engage in insulin production following
Externí odkaz:
https://doaj.org/article/bb558558df6c406fb5d12e3bdfc0c628
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101268- (2021)
Objective: Glucagon is secreted by pancreatic α-cells in response to hypoglycemia and its hyperglycemic effect helps to restore normal blood glucose. Insulin and somatostatin (SST) secretions from β- and δ-cells, respectively, are stimulated by gl
Externí odkaz:
https://doaj.org/article/ce9607451ba8401b83da6ae7fad1e1b7
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
The β-cell regeneration field has shown a strong knowledge boost in the last 10 years. Pluripotent stem cell differentiation and direct reprogramming from other adult cell types are becoming more tangible long-term diabetes therapies. Newly generate
Externí odkaz:
https://doaj.org/article/74abd05cd4f7405596f1bc051b6671b4
Autor:
Heeyoung Chae, Robert Augustin, Eva Gatineau, Eric Mayoux, Mohammed Bensellam, Nancy Antoine, Firas Khattab, Bao-Khanh Lai, Davide Brusa, Birgit Stierstorfer, Holger Klein, Bilal Singh, Lucie Ruiz, Michael Pieper, Michael Mark, Pedro L. Herrera, Fiona M. Gribble, Frank Reimann, Anne Wojtusciszyn, Christophe Broca, Nano Rita, Lorenzo Piemonti, Patrick Gilon
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101071- (2020)
Objective: Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i), or gliflozins, are anti-diabetic drugs that lower glycemia by promoting glucosuria, but they also stimulate endogenous glucose and ketone body production. The likely causes of the
Externí odkaz:
https://doaj.org/article/21bfada24dc04976b5da4c463b456525
Autor:
Marianne Böni-Schnetzler, Stéphanie P. Häuselmann, Elise Dalmas, Daniel T. Meier, Constanze Thienel, Shuyang Traub, Friederike Schulze, Laura Steiger, Erez Dror, Praxedis Martin, Pedro L. Herrera, Cem Gabay, Marc Y. Donath
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1774-1786 (2018)
Summary: Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β
Externí odkaz:
https://doaj.org/article/57e70e42c68f4540a15c19f5916584e6
Autor:
Marta Perez-Frances, Léon van Gurp, Maria Valentina Abate, Valentina Cigliola, Kenichiro Furuyama, Eva Bru-Tari, Daniel Oropeza, Taïna Carreaux, Yoshio Fujitani, Fabrizio Thorel, Pedro L. Herrera
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/6f207e3c3853427cbde783d0f50e6c14