Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Pedro J. Real"'
Autor:
Joan Domingo-Reinés, Rosa Montes, Adrián Garcia-Moreno, Amador Gallardo, Jose Manuel Sanchez-Manas, Iván Ellson, Mar Lamolda, Chiara Calabro, Jose Antonio López-Escamez, Purificación Catalina, Pedro Carmona-Sáez, Pedro J. Real, David Landeira, Verónica Ramos-Mejia
Publikováno v:
Cell Death and Disease, Vol 14, Iss 6, Pp 1-12 (2023)
Abstract Pediatric Acute Myeloid Leukemia (AML) is a rare and heterogeneous disease characterized by a high prevalence of gene fusions as driver mutations. Despite the improvement of survival in the last years, about 50% of patients still experience
Externí odkaz:
https://doaj.org/article/cd8444ff40804d0bb9b17a413dfc920d
Autor:
Qingqing Yan, Phillip Wulfridge, John Doherty, Jose L. Fernandez-Luna, Pedro J. Real, Hsin-Yao Tang, Kavitha Sarma
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
R-loops are three-stranded nucleic acid structures that contribute to genome instability and accumulate in neurological diseases. Here the authors identify R-loop proximal factors, which are enriched for zinc finger and homeodomain proteins, includin
Externí odkaz:
https://doaj.org/article/cb8dad63113f446f9ed14a035477d404
Autor:
Joan Domingo-Reinés, Gonzalo Martínez-Navajas, Rosa Montes, Mar Lamolda, Iris Simón, Julio Castaño, Rosa Ríos-Pelegrina, Javier Luis Lopez-Hidalgo, Raimundo García del Moral, Juan A. Marchal, Pedro J. Real, Verónica Ramos-Mejía
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Pediatric acute myeloid leukemia (AML) is a rare and heterogeneous disease that remains the major cause of mortality in children with leukemia. To improve the outcome of pediatric AML we need to gain knowledge on the biological bases of this disease.
Externí odkaz:
https://doaj.org/article/0eb7a0b1ec7949e59ed05681b69ce025
Autor:
Raquel Sanabria-de la Torre, Luis Martínez-Heredia, Sheila González-Salvatierra, Francisco Andújar-Vera, Iván Iglesias-Baena, Juan Miguel Villa-Suárez, Victoria Contreras-Bolívar, Mario Corbacho-Soto, Gonzalo Martínez-Navajas, Pedro J. Real, Cristina García-Fontana, Manuel Muñoz-Torres, Beatriz García-Fontana
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Hypophosphatasia (HPP) a rare disease caused by mutations in the ALPL gene encoding for the tissue-nonspecific alkaline phosphatase protein (TNSALP), has been identified as a potentially under-diagnosed condition worldwide which may have higher preva
Externí odkaz:
https://doaj.org/article/6b8f1fbf88af40f096d6a33378987f4e
Autor:
Sabina Sánchez-Hernández, Alejandra Gutierrez-Guerrero, Rocío Martín-Guerra, Marina Cortijo-Gutierrez, María Tristán-Manzano, Sandra Rodriguez-Perales, Laura Sanchez, Jose Luis Garcia-Perez, Jesus Chato-Astrain, Ricardo Fernandez-Valades, Ana Belén Carrillo-Galvez, Per Anderson, Rosa Montes, Pedro J. Real, Francisco Martin, Karim Benabdellah
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 16-28 (2018)
Integration-defective lentiviral vectors (IDLVs) have become an important alternative tool for gene therapy applications and basic research. Unfortunately, IDLVs show lower transgene expression as compared to their integrating counterparts. In this s
Externí odkaz:
https://doaj.org/article/72961106e0f041648c1d03824c09a7c3
Autor:
Mar Lamolda, Rosa Montes, Iris Simón, Sonia Perales, Gonzalo Martínez-Navajas, Lourdes Lopez-Onieva, Rosa Ríos-Pelegrina, Raimundo García del Moral, Carmen Griñan-Lison, Juan A. Marchal, Maria L. Lozano, Veronica Ramos-Mejia, Jose Rivera, Jose M. Bastida, Pedro J. Real
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
Familial Platelet Disorder with associated Myeloid Malignancy (FPDMM) is a rare platelet disorder caused by mutations in RUNX1. We generated an iPSC line (GENYOi005-A) from a FPDMM patient with a non-previously reported variant p.Thr196Ala. Non-integ
Externí odkaz:
https://doaj.org/article/6688e7d866c1411b90afc4c278943f03
Autor:
Marina Cortijo-Gutiérrez, Sabina Sánchez-Hernández, María Tristán-Manzano, Noelia Maldonado-Pérez, Lourdes Lopez-Onieva, Pedro J. Real, Concha Herrera, Juan Antonio Marchal, Francisco Martin, Karim Benabdellah
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1217 (2021)
Integration-deficient lentiviral vectors (IDLVs) have recently generated increasing interest, not only as a tool for transient gene delivery, but also as a technique for detecting off-target cleavage in gene-editing methodologies which rely on custom
Externí odkaz:
https://doaj.org/article/90c0b68d11e444c29a86cdfb4e043412
Autor:
Lourdes Lopez-Onieva, Mar Lamolda, Rosa Montes, Maria Luisa Lozano, Vicente Vicente, José Rivera, Verónica Ramos-Mejía, Pedro J. Real
Publikováno v:
Stem Cell Research, Vol 20, Iss C, Pp 10-13 (2017)
Bernard Soulier Syndrome (BSS) is a rare autosomal platelet disorder characterized by mutations in the von Willebrand factor platelet receptor complex GPIb-V-IX. In this work we have generated an induced pluripotent stem cell (BSS3-PBMC-iPS4F8) from
Externí odkaz:
https://doaj.org/article/399cf44d5dd3481d8c25f9475aeda207
Autor:
Elena López-Ruiz, Seshasailam Venkateswaran, Macarena Perán, Gema Jiménez, Salvatore Pernagallo, Juan J. Díaz-Mochón, Olga Tura-Ceide, Francisco Arrebola, Juan Melchor, Juan Soto, Guillermo Rus, Pedro J. Real, María Diaz-Ricart, Antonio Conde-González, Mark Bradley, Juan A. Marchal
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Decellularized vascular scaffolds are promising materials for vessel replacements. However, despite the natural origin of decellularized vessels, issues such as biomechanical incompatibility, immunogenicity risks and the hazards of thrombus
Externí odkaz:
https://doaj.org/article/277e4c5adca947e99621d87e4cd3c23a
Autor:
Rosa Montes, Pilar Mollinedo, Sonia Perales, Domingo Gonzalez-Lamuño, Veronica Ramos-Mejía, Jose L. Fernandez-Luna, Pedro J. Real
Publikováno v:
Stem Cell Research, Vol 37, Iss , Pp - (2019)
ADNP syndrome is an intellectual disability associated with Autism spectrum disorder caused by mutations in ADNP. We generated an iPSC line from an ADNP syndrome pediatric patient harboring the mutation p.Trp719* (GENYOi004-A). Peripheral blood monon
Externí odkaz:
https://doaj.org/article/6ab74d7d8ea946f68cd05b3aae56ba6e