Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Pedro J. Otaegui"'
Autor:
Patricia V. Turner, Debra L. Hickman, Judith van Luijk, Merel Ritskes-Hoitinga, Jan M. Sargeant, T. Miki Kurosawa, Takashi Agui, Vera Baumans, Woo Sung Choi, Yang-Kyu Choi, Paul A. Flecknell, Byeong H. Lee, Pedro J. Otaegui, Kathleen R. Pritchett-Corning, Keisuke Shimada
Publikováno v:
Frontiers in Veterinary Science, Vol 7 (2020)
Background: There has been increased concern about the suitability of CO2 as a method for euthanasia of laboratory mice and rats, including the potential discomfort, pain or distress that animals may experience prior to loss of consciousness; time to
Externí odkaz:
https://doaj.org/article/60a688d1cdda40cf869af78cd9ce6ed0
Autor:
Daniel Sampedro-Viana, Cristóbal Río-Álamos, Ignasi Oliveras, Gloria Blázquez, Toni Cañete, Ana Sánchez-González, Carlos Baldellou, Alberto Fernández-Teruel, Cristina Gerbolés, Carles Tapias-Espinosa, María del Mar López, Pedro J. Otaegui, Adolf Tobeña
Publikováno v:
Behavior Genetics. 47:537-551
The Roman high- (RHA-I) and low-avoidance (RLA-I) rat strains are bi-directionally bred for their good versus non-acquisition of two-way active avoidance, respectively. They have recently been re-derived through embryo transfer (ET) to Sprague-Dawley
Autor:
Joan Ballester, Dolors Izquierdo, Roger R. Gomis, Joan C. Ferrer, Joan E. Rodríguez-Gil, Pedro J. Otaegui, Joan J. Guinovart, Josep M. Fernández-Novell, Teresa Mogas, M.J. Palomo, Teresa Rigau
Publikováno v:
Biochemical and Biophysical Research Communications. 297:841-846
Intra-testicular inoculation of an adenoviral vector carrying the fusion gene Aequorea victoria green fluorescence protein/rat-liver glycogen synthase (GFP/LGS) resulted in the presence of GFP/GLS in spermatozoa from 7 days to, at least, 16 days afte
Autor:
Alex Mas, Lluis Montoliu, Anna Pujol, Efren Riu, Laurent Gros, Pedro J. Otaegui, Fatima Bosch, Tura Ferre
Publikováno v:
Diabetes. 51:704-711
Insulin replacement therapy in type 1 diabetes is imperfect because proper glycemic control is not always achieved. Most patients develop microvascular, macrovascular, and neurological complications, which increase with the degree of hyperglycemia. E
Autor:
Jesús Ruberte, Xavier Navarro, Lorena Ariza, S. Cobianchi, Pedro J. Otaegui, Assumpció Bosch, Gemma Pagès, Belén García-Lareu, Miguel Chillón
Publikováno v:
Neuroscience. 274
Animal models of diabetes do not reach the severity of human diabetic neuropathy but relatively mild neurophysiological deficits and minor morphometric changes. The lack of degenerative neuropathy in diabetic rodent models seems to be a consequence o
Autor:
R.M. Rabanal, Mireia Zaguirre, Lorena Ariza, Assumpició Bosch, Pedro J. Otaegui, Ester Blasco, Marta Garcia
Publikováno v:
Lab animal. 43(7)
Repeated, low-dose administration of streptozotocin (STZ) is widely used to induce insulin-dependent diabetes mellitus in mice. The authors adapted this method using neonatal mice and determined the long-term effects of STZ injection in the mice. Aft
Autor:
Antonio Hidalgo, Fatima Bosch, Alex Mas, Sylvie Franckhauser, Efren Riu, Tura Ferre, Pedro J. Otaegui
Publikováno v:
The FASEB Journal. 17:1715-1717
Alterations in hepatic glucose metabolism play a key role in the development of the hyperglycemia observed in type 2 diabetes. Because the transcription factor c-Myc induces hepatic glucose uptake and utilization and blocks gluconeogenesis, we examin
Autor:
Fatima Bosch, Carles Roca, Xavier M. Anguela, Mercè Obach, Pedro J. Otaegui, Lluis M. Mir, Joel Montane, Christopher J. Mann, Albert Ruzo
Publikováno v:
Gene therapy. 19(12)
Electrotransfer of plasmid DNA in skeletal muscle is a common non-viral delivery method for both therapeutic genes and DNA vaccines. Yet, despite the similar approaches, an immune response is detrimental in gene therapy, but desirable for vaccines. H
Autor:
Pedro J. Otaegui, Fatima Bosch, Efren Riu, Alex Mas, Xavier M. Anguela, Anne Douar, Joel Montane, Sergio Muñoz
Publikováno v:
Diabetes. 55(6)
Type 1 diabetic patients develop severe secondary complications because insulin treatment does not guarantee normoglycemia. Thus, efficient regulation of glucose homeostasis is a major challenge in diabetes therapy. Skeletal muscle is the most import
Autor:
Joel Montane, Judith Agudo, Miguel Chillón, Fatima Bosch, Eduard Ayuso, Pedro J. Otaegui, Anna Andaluz, Ana Carretero, Félix García, Mercè Monfar, Marta Moya
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 13(4)
Gene therapy may provide new treatments for severe pancreatic disorders. However, gene transfer to the pancreas is difficult because of its anatomic location and structure, and pancreatitis is a serious concern. Like the human pancreas, the canine pa